Long Field Of View MRA Using Continuous Table Motion

使用连续工作台运动的长视场 MRA

• 批准号: 7915510
• 负责人: Stephen J Riederer
• 金额: $ 38.43万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915510
• 关键词: Abdomen; Acceleration; Accounting; Age; Aging; Algorithms; Anatomy; Angiography; Applications Grants; Arteries; Blood flow; Bolus Infusion; Detection; Development; Diagnosis; Diagnostic; Dimensions; Distal; Dose; Goals; Image; Intravenous; Investigation; Lateral; Leg; Lower Extremity; Magnetic Resonance Imaging; Measures; Methodology; Methods; Morphologic artifacts; Motion; Patients; Pelvis; Peripheral; Peripheral Vascular Diseases; Phase; Physics; Physiologic pulse; Physiological; Population; Positioning Attribute; Preparation; Property; R-factor; Resolution; Scanning; Signal Transduction; Simulate; Speed; Techniques; Testing; Time; United States; computerized data processing; data acquisition; experience; foot; improved; in vivo; method development; public health relevance; reconstruction; research clinical testing; resistance factors

DESCRIPTION (provided by applicant): The long term objective of this project continues to be the development of methods which permit MR data acquisition during continuous motion of the patient table for contrast-enhanced MR angiographic studies of the peripheral vasculature. This will allow diagnostic quality imaging of the vasculature from the abdomen and pelvis to the feet to allow diagnosis and characterization of peripheral vascular disease. Imaging during continuous table motion permits high efficiency in the use of scan time and of the contrast dose. Because a given axial level is imaged within the moving field-of-view for only a limited time, typically 20 sec or less, it is critical to allow improvements in spatial resolution for a given acquisition time. To this end, acceleration techniques demonstrated in Years 01-04 in one dimension will be extended to the two lateral dimensions. Another major aim of the study is to image the contrast dose transit in real time, automatically track its position, and use this information to automatically adjust the table velocity. The grant application includes the following specific aims: 1. High Resolution CE-MRA of a Fixed FOV Using 2D Acceleration Techniques. In preparation for imaging during continuous table motion, techniques will first be developed for performing highly accelerated acquisitions during no table motion within a targeted 16 sec. The elliptical centric view order will be combined with 2D homodyne, 2D SENSE, and time-resolved view-shared acquisition for 1 mm isotropic resolution. 2. Parallel Acquisition Techniques Applied During Continuous Table Motion. The accelerated acquisition methods of Aim #1 will be adapted to continuously moving table imaging. Reconstruction algorithms will be developed which account for gradient warping, 2D SENSE-homodyne, and variable FOV acquisition. Coils will be developed which allow efficient 15x accelerated 2D parallel acquisition over an extended FOV. 3. Patient-Specific Acquisition for Continuously Moving Table Peripheral MRA. Methods will be developed to detect the leading edge of the contrast bolus as it moves along the peripheral vasculature and then to use this information to alter the patient table motion in real time. This will be tested initially in phantoms and then using a test bolus. The final technique will be one in which an extended-FOV, high spatial resolution, arterial phase peripheral angiogram is formed by automatically tracking the full contrast bolus with no need for a test bolus. PUBLIC HEALTH RELEVANCE: Peripheral vascular disease is a major problem in the population of the United States, and it is important to image and diagnosis this condition in an easy, accurate, reliable, safe manner which not only accounts for patient-to-patient differences in anatomy and blood flow but also accommodates the long field of view which ex- tends from the abdomen to the feet. This project is relevant to this problem, as the goal is to develop a method which allows high spatial resolution MR imaging of the extended vasculature by using a moving patient table uniquely tuned to the transit of intravenous contrast material within each patient.

描述（由申请人提供）：本项目的长期目标仍然是开发允许在患者扫描床连续运动期间采集MR数据的方法，用于外周血管系统的对比增强MR血管造影研究。这将允许从腹部和骨盆到足部的血管系统的诊断质量成像，以允许诊断和表征外周血管疾病。在连续床运动期间的成像允许在扫描时间和造影剂剂量的使用方面的高效率。由于给定轴向水平在移动视场内仅成像有限时间，通常为20秒或更短，因此允许在给定采集时间内提高空间分辨率至关重要。为此，在01-04年在一维中演示的加速技术将扩展到两个横向维度。本研究的另一个主要目的是对造影剂剂量传输进行真实的实时成像，自动跟踪其位置，并使用此信息自动调整扫描床速度。资助申请包括以下具体目标：1。使用2D加速技术的固定FOV的高分辨率CE-MRA。在连续扫描床运动期间准备成像时，将首先开发在目标16秒内无扫描床运动期间执行高加速采集的技术。椭圆中心视图顺序将与2D零差、2D SENSE和时间分辨视图共享采集相结合，以获得1 mm各向同性分辨率。2.工作台连续运动中的并行采集技术。目标#1的加速采集方法将适用于连续移动扫描床成像。将开发重建算法，以解释梯度扭曲、2D SENSE零差和可变FOV采集。将开发的线圈允许在扩展FOV上进行有效的15倍加速2D并行采集。3.连续移动床外周MRA的患者特定采集。当造影剂团沿外周血管沿着移动时，将开发检测造影剂团前沿的方法，然后使用该信息以真实的时间改变患者检查床运动。这将首先在体模中进行测试，然后使用测试大剂量。最终的技术将是一种扩展FOV、高空间分辨率、动脉相外周血管造影片，通过自动跟踪全造影剂团形成，无需测试团。公共卫生相关性：外周血管疾病是美国人口中的主要问题，并且以简单、准确、可靠、安全的方式对这种状况进行成像和诊断是重要的，这不仅考虑到患者与患者在解剖结构和血流方面的差异，而且还适应从腹部延伸到足部的长视野。该项目与该问题相关，因为目标是开发一种方法，该方法通过使用唯一调谐到每个患者体内静脉内造影剂运输的移动患者检查床，允许扩展血管系统的高空间分辨率MR成像。