Mapping and Modulating the Spatiotemporal dynamics of socio-affective processing.
映射和调节社会情感处理的时空动态。
基本信息
- 批准号:10661560
- 负责人:
- 金额:$ 59.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAffectiveAmygdaloid structureAnteriorAnxiety DisordersArchitectureBehavioralCategoriesCommunicationCorpus striatum structureDataDeep Brain StimulationDepressed moodDepressive disorderDiagnosticElectrodesElectroencephalographyElectrophysiology (science)EmotionalEpilepsyEtiologyEvaluationEvoked PotentialsFaceFace ProcessingFacial ExpressionFailureFeelingFeeling hopelessFunctional disorderGoalsHumanMapsMediatingMedicineMental DepressionMethodologyMonitorMood DisordersMoodsMotor ActivityNegative ValenceNoiseOperative Surgical ProceduresParentsPatient Self-ReportPatientsPatternPhysiologic pulseProcessProductionPropertyReportingResearch Domain CriteriaResistanceRestRoleSignal TransductionSocial EnvironmentSocial isolationStructure of superior temporal sulcusSymptomsSystemTherapeuticarea striataautism spectrum disorderbehavior measurementbrain behaviorburden of illnesscingulate cortexcognitive taskcohortcollegedepressive symptomsdiffusion weightedemotional functioningemotional stimulusfallsfirst-in-humanfusiform face areaimprovedindexinginnovationnetwork dysfunctionneuralneuroimagingneuropsychiatric disorderneuropsychiatryneuroregulationnovelnovel therapeuticspositive moodresponsesocialsocial cognitionspatiotemporaltemporal measurementtreatment-resistant depressionwhite matter
项目摘要
ABSTRACT
Interpreting human facial expressions is a core human social capacity negatively impacted in diverse
neuropsychiatric conditions. Failures of human social cognition contribute to disease burden in mood
disorders, as well as autism spectrum and anxiety disorders, reinforcing and exacerbating the social isolation
and hopelessness of patients across diagnostic categories. The proposed study examines the RDoC
subconstruct of “Facial Communication” and the domain of “Negative Valence Systems” using behavioral
cognitive tasks that place heavy demands on the capacity to interpret emotional facial expressions. Prior
efforts to develop neuromodulation paradigms for treatment-resistant cases of neuropsychiatric diseases
characterized by socio-affective dysfunction have fallen short, in part due to an absence of defined neural
dysfunctional-state signals. The overall goal of this R01 proposal is to map the spatiotemporal dynamics of
social affective processing and to examine selective modulation of these dynamics in humans undergoing
invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a
novel platform with invasive intracranial recording electrodes provides much-needed spatial and
temporal resolution to characterize the neural dynamics of socio-affective processing. We will leverage
first-in-human intracranial neural recording opportunities created by a novel therapeutic platform termed
“stereotactic electroencephalography-informed deep brain stimulation” (stereo-EEG-informed DBS; Parent
Study UH3-NS103549), as well as the powerful platform of intracranial stereotactic recording and stimulation in
patients undergoing epilepsy surgical evaluation at Baylor College of Medicine. The sEEG-informed DBS trial
provides unique opportunities for intracranial recording of affect-relevant network regions in patients with
treatment-resistant depression (TRD). Recordings in identical regions in epilepsy patients who themselves
often demonstrate mild-moderate depressive symptoms will provide a wide dynamic range across the
symptom spectrum. To provide critical data on the spatiotemporal dynamics of socio-affective processing we
will leverage these two human intracranial recording and stimulation cohorts to study the precise structural
(Aim 1), functional (Aim 2), and causal (Aim 3) properties of the affective salience network. Greater
understanding of the social processing circuitry mediated by the affective salience network may be used to
drive therapeutic innovation, pioneering a new paradigm that improves socio-emotional function across a wide
variety of neuropsychiatric conditions. The results from this proposal have the potential to improve the lives of
patients with dysfunction in social affective processing, with implications for a wide range of neuropsychiatric
diseases.
摘要
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Identifying the neurophysiological effects of memory-enhancing amygdala stimulation using interpretable machine learning.
使用可解释的机器学习来识别增强记忆杏仁核刺激的神经生理效应。
- DOI:10.1016/j.brs.2021.09.009
- 发表时间:2021-11
- 期刊:
- 影响因子:7.7
- 作者:Sendi, Mohammad S. E.;Inman, Cory S.;Bijanki, Kelly R.;Blanpain, Lou;Park, James K.;Hamann, Stephan;Gross, Robert E.;Willie, Jon T.;Mahmoudi, Babak
- 通讯作者:Mahmoudi, Babak
In Reply: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation.
回复:网络靶向神经精神深部脑刺激的新框架。
- DOI:10.1093/neuros/nyab308
- 发表时间:2021
- 期刊:
- 影响因子:4.8
- 作者:Allawala,Anusha;Bijanki,KellyR;Goodman,Wayne;Cohn,JeffreyF;Viswanathan,Ashwin;Yoshor,Daniel;Borton,DavidA;Pouratian,Nader;Sheth,SameerA
- 通讯作者:Sheth,SameerA
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Kelly Rowe Bijanki其他文献
Kelly Rowe Bijanki的其他文献
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{{ truncateString('Kelly Rowe Bijanki', 18)}}的其他基金
Intracranial Investigation of Neural Circuity Underlying Human Mood
人类情绪背后的神经回路的颅内研究
- 批准号:
10660355 - 财政年份:2023
- 资助金额:
$ 59.2万 - 项目类别:
Mapping and Modulating the Spatiotemporal dynamics of socio-affective processing.
映射和调节社会情感处理的时空动态。
- 批准号:
10283108 - 财政年份:2021
- 资助金额:
$ 59.2万 - 项目类别:
Mapping and Modulating the Spatiotemporal dynamics of socio-affective processing.
映射和调节社会情感处理的时空动态。
- 批准号:
10452629 - 财政年份:2021
- 资助金额:
$ 59.2万 - 项目类别:
The human amygdala in social processing: circuits, physiology, behavior, and neuromodulation
社会处理中的人类杏仁核:回路、生理学、行为和神经调节
- 批准号:
10226279 - 财政年份:2019
- 资助金额:
$ 59.2万 - 项目类别:
The human amygdala in social processing: circuits, physiology, behavior, and neuromodulation
社会处理中的人类杏仁核:回路、生理学、行为和神经调节
- 批准号:
9927864 - 财政年份:2019
- 资助金额:
$ 59.2万 - 项目类别:
The human amygdala in social processing: circuits physiology behavior and neuromodulation.
社会处理中的人类杏仁核:电路生理学行为和神经调节。
- 批准号:
9666633 - 财政年份:2018
- 资助金额:
$ 59.2万 - 项目类别:
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