Mentorship in Clinical Complementary and Integrative Health Research

临床补充和综合健康研究的指导

• 批准号: 10670137
• 负责人: Ryan D Bradley
• 金额: $ 15.52万
• 依托单位: NATIONAL UNIVERSITY OF NATURAL MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670137
• 关键词: Administrative Supplement; Adult; Applications Grants; Appointment; Award; Awareness; Biological; Biological Markers; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Competence; Complementary Health; Critical Pathways; Data; Dedications; Doctor of Philosophy; Environment; Epidemiologist; Exposure to; Funding; Future; Future Generations; Goals; Health; Industry; Integrative Medicine; International; Investments; K-Series Research Career Programs; Laboratories; Measurement; Mediator; Medical Research; Medicine; Mentors; Mentorship; Methodology; Methods; National Center for Complementary and Integrative Health; Natural Products; Oregon; Pacific Northwest; Pharmacy Schools; Phase I Clinical Trials; Phase II Clinical Trials; Population; Positioning Attribute; Postdoctoral Fellow; Publications; Qualifying; Request for Proposals; Research; Research Activity; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Safety; Sampling; Science; Scientist; Structure; Training; Training Activity; Training Programs; Translational Research; United States; United States National Institutes of Health; Universities; Washington; Work; career; career development; clinical care; clinical epidemiology; cohort; equity, diversity, and inclusion; experience; graduate student; improved; interest; mid-career faculty; post-doctoral training; programs; response; skills; transcription factor; translational physician; translational scientist

Because over 50% of adults in the United States take complementary and integrative health (CIH) natural products for their health, the training of CIH practitioners and scientists to produce high-quality clinical research is imperative to identifying effective products for the safety of the public. As such, this proposal requests a K24 mid-career development award to expand and support mentorship in clinical natural product research by Dr. Ryan Bradley, ND, MPH. Dr. Bradley has demonstrated effective mentorship by the publication of all past mentees, and the progression of multiple mentees from graduate students to formal NIH post-doctoral training awards, and independent training awards. Dr. Bradley is currently a Program Director and mentor in the NCCIH- funded T90/R90 Building Research across Interdisciplinary Gaps (BRIDG) clinical research training program formed in partnership between the University of Washington (UW) and the National University of Natural Medicine (NUNM). Dr. Bradley provides mentorship for 10 post-doctoral trainees, including CIH clinicians and PhD scientists. Dr. Bradley is a primary mentor for a T90 trainee who has progressed onto a KL2 award at the UW, a CIH practitioner who received a NICCH administrative supplement to gain research experience on Dr. Bradley's R01-funded clinical trials, and a T32 post-doctoral trainee in the ORCCAMIND T32 program at Oregon Health & Sciences University (for which Dr. Bradley is a formal mentor). In addition to his positions as Director of Research, Senior Investigator and Associate Professor at the NUNM, he retains affiliate and adjunct appointments at 3 US-based and 2 international universities, thus Dr. Bradley is extremely well connected to assist mentees in identifying resources and collaborators for their research. The Specific Aims of this proposal are for Dr. Bradley to: 1. Dedicate consistent effort in the mentorship of promising trainees in T32, T90, R90, and KL2 programs in order to facilitate their progression in research training and independent research (Aim 1); 2. Refine and develop mentoring skills by pursuing additional training in: mentorship; diversity, equity and inclusion in research; and cutting-edge translational science methodologies (Aim 2); and 3. Provide exposure to translational science methods and provide publication opportunities for mentees through the collection of additional preliminary data related to recent clinical trials of specialized pro-resolvin mediators (SPM) and xanthohumol natural products, including product quality assessment, measurement of relevant biomarkers in stored biologic samples, and measurement of additional transcription factors (PCSK9) to extend the research to new clinical populations (Aim 3).

因为美国超过50％的成年人自然而然地享有互补和综合健康（CIH） 健康的产品，培训CIH从业者和科学家生产高质量临床研究 必须确定有效的产品以确定公众的安全。因此，该建议要求K24 中级发展奖旨在扩大和支持Dr.临床自然产品研究的指导 瑞安·布拉德利（Ryan Bradley），ND，MPH。布拉德利博士通过所有过去的出版证明了有效的指导 受训者，以及多名受训者从研究生到正式NIH博士后培训的发展 奖项和独立培训奖。 Bradley博士目前是NCCIH-的计划总监和导师 跨学科差距（BRIDG）临床研究培训计划的资助T90/R90建筑研究 由华盛顿大学（UW）与国立自然大学之间的合作伙伴关系 医学（Nunm）。布拉德利博士为10名博士后学员提供指导，包括CIH临床医生和 博士科学家。布拉德利博士是T90培训生的主要导师，他在 UW，CIH从业者，获得了NICC的行政补充，以获得有关博士的研究经验 Bradley的R01资助的临床试验和俄勒冈州Orccamind T32计划的T32博士后学员 卫生与科学大学（布拉德利博士是正式导师）。除了担任导演的职位 研究，NUNM的高级研究员兼副教授，他保留了会员和兼职 在3所美国和2所国际大学的约会，因此布拉德利博士与 协助受训者确定其研究的资源和合作者。该提议的具体目的 是为Bradley博士致：1。在T32，T90，R90和 KL2计划是为了促进其在研究培训和独立研究中的进展（AIM 1）； 2。 通过接受其他培训来完善和发展指导技能：指导；多样性，公平和包容性 在研究中；和尖端的翻译科学方法论（AIM 2）；和3。提供接触 翻译科学方法，并通过收集为受训者提供出版机会 与最新的专业亲溶剂介质（SPM）和 Xanthhohumol天然产品，包括产品质量评估，测量相关生物标志物 存储的生物样品以及测量其他转录因子（PCSK9），以将研究扩展到 新的临床人群（AIM 3）。

项目成果

Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline.

• DOI: 10.3233/jad-230004
• 发表时间: 2023
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Sandison, Heather;Callan, Nini G. L.;Rao, Rammohan V.;Phipps, John;Bradley, Ryan
• 通讯作者: Bradley, Ryan