Mentorship in Clinical Complementary and Integrative Health Research

因为超过50%的美国成年人认为补充和综合健康(CIH)是天然的 为他们的健康而生产产品，培训CIH从业者和科学家以产生高质量的临床研究 为了公众的安全，确定有效的产品势在必行。因此，该提案要求K24 职业生涯中期发展奖，以扩大和支持临床天然产物研究的导师。 瑞安·布拉德利，ND，最高时速。布拉德利博士出版了《过去的一切》，证明了他的指导是有效的。 以及从研究生到NIH正式博士后培训的多个导师的进步 奖项，以及独立培训奖。布拉德利博士目前是NCCIH的项目主任和导师- 资助跨学科差距的T90/R90构建研究(Bridg)临床研究培训计划 由华盛顿大学(UW)和国立自然大学合作成立 医学(NUNM)。布拉德利博士为10名博士后实习生提供指导，其中包括CIH临床医生和 博士生科学家。布拉德利博士是一名T90学员的主要导师，这名学员在 他获得了NICCH的行政补充，以获得对Dr的研究经验。 Bradley的R01资助的临床试验，以及俄勒冈州ORCCAMIND T32项目的T32博士后实习生 健康与科学大学(布拉德利博士是该大学的正式导师)。除了他作为董事的职位 NUNM研究部高级研究员兼副教授，他保留附属机构和附属机构 在3所美国大学和2所国际大学的任命，因此布拉德利博士与 协助被辅导者确定他们研究的资源和合作者。这项建议的具体目的 布拉德利博士要做的是：1.始终如一地指导T32、T90、R90和 KL2方案，以促进其在研究、培训和独立研究方面的进展(目标1)； 通过进行以下方面的额外培训，完善和发展指导技能：指导；多样性、公平和包容性 在研究中；和尖端的翻译科学方法(目标2)；和3.提供 翻译科学方法，并通过收集 其他初步数据与最近专门的溶血素前体(SPM)临床试验和 黄腐酚天然产物，包括产品质量评估，相关生物标志物的测定 储存的生物样本，以及额外转录因子(PCSK9)的测量，以将研究扩展到 新的临床人群(目标3)。

Because over 50% of adults in the United States take complementary and integrative health (CIH) natural products for their health, the training of CIH practitioners and scientists to produce high-quality clinical research is imperative to identifying effective products for the safety of the public. As such, this proposal requests a K24 mid-career development award to expand and support mentorship in clinical natural product research by Dr. Ryan Bradley, ND, MPH. Dr. Bradley has demonstrated effective mentorship by the publication of all past mentees, and the progression of multiple mentees from graduate students to formal NIH post-doctoral training awards, and independent training awards. Dr. Bradley is currently a Program Director and mentor in the NCCIH- funded T90/R90 Building Research across Interdisciplinary Gaps (BRIDG) clinical research training program formed in partnership between the University of Washington (UW) and the National University of Natural Medicine (NUNM). Dr. Bradley provides mentorship for 10 post-doctoral trainees, including CIH clinicians and PhD scientists. Dr. Bradley is a primary mentor for a T90 trainee who has progressed onto a KL2 award at the UW, a CIH practitioner who received a NICCH administrative supplement to gain research experience on Dr. Bradley's R01-funded clinical trials, and a T32 post-doctoral trainee in the ORCCAMIND T32 program at Oregon Health & Sciences University (for which Dr. Bradley is a formal mentor). In addition to his positions as Director of Research, Senior Investigator and Associate Professor at the NUNM, he retains affiliate and adjunct appointments at 3 US-based and 2 international universities, thus Dr. Bradley is extremely well connected to assist mentees in identifying resources and collaborators for their research. The Specific Aims of this proposal are for Dr. Bradley to: 1. Dedicate consistent effort in the mentorship of promising trainees in T32, T90, R90, and KL2 programs in order to facilitate their progression in research training and independent research (Aim 1); 2. Refine and develop mentoring skills by pursuing additional training in: mentorship; diversity, equity and inclusion in research; and cutting-edge translational science methodologies (Aim 2); and 3. Provide exposure to translational science methods and provide publication opportunities for mentees through the collection of additional preliminary data related to recent clinical trials of specialized pro-resolvin mediators (SPM) and xanthohumol natural products, including product quality assessment, measurement of relevant biomarkers in stored biologic samples, and measurement of additional transcription factors (PCSK9) to extend the research to new clinical populations (Aim 3).