Mentoring Translational Scientists in Clinical Trial Immune Monitoring

指导转化科学家进行临床试验免疫监测

• 批准号: 10670051
• 负责人: Emanual M. Maverakis
• 金额: $ 18.77万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670051
• 关键词: Academy; Age; Age Years; Ancillary Study; Asthma; Autoimmune Diseases; Autoimmunity; Award; B-Lymphocytes; Big Data Methods; Biological Markers; Cancer Patient; Cells; Charge; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Culture Media; Data; Data Set; Development; Diagnostic; Disease; Dissociation; Distant; Dose; Double-Blind Method; Educational process of instructing; Ensure; Etiology; Female; Functional disorder; Future; Galactose; Gender; Genetic; Glycobiology; Glycocalyx; Glycoconjugates; Glycopeptides; Glycoproteins; Goals; Human; Hypersensitivity; IgE; Immunogenetics; Immunoglobulin G; Immunologic Monitoring; Immunologics; Immunotherapy; Individual; Inflammatory; Institution; Isomerism; Laboratories; Libraries; Lipids; Liquid Chromatography; Maps; Measures; Mediating; Mentors; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Monitor; National Research Council; Nucleic Acids; Oral; Organism; Pathogenicity; Patients; Pattern; Phase I Clinical Trials; Physicians; Pilot Projects; Placebo Control; Plasma; Play; Polysaccharides; Prediction of Response to Therapy; Procedures; Proteins; Protocols documentation; Randomized; Research; Research Design; Resource Sharing; Rheumatoid Arthritis; Role; Sampling; Scientist; Serum; Severity of illness; Site; Technology; Therapeutic; Time; Training; Translating; United States National Institutes of Health; clinical application; clinical training; clinically relevant; cytokine; experience; feeding; glycosylation; human disease; improved; instrumentation; interest; male; monomer; multiple reaction monitoring; novel; patient oriented research; phase 1 study; prognostic; technology development; translational scientist

Title: Mentoring Physician Scientists in Patient-Oriented Research ABSTRACT Dr. Maverakis is a physician-scientist trained in immunogenetics, glycobiology, and big data analytics. His research focuses on the use of state-of-the-art methodologies to study patients with autoimmunity and cancer patients receiving immunotherapy. His group constructs diagnostic classifiers, as well as predictive classifiers to identify patients who will: experience a progression in disease severity, respond to a particular therapy, or develop an associated disease. With this goal in mind, Dr. Maverakis and his collaborator, Carlito Lebrilla, have created a site-specific map of the human serum glycome for use in biomarker research and discovery. Dr. Maverakis is an award-winning mentor with a strong track-record of training clinical-investigators. He is the director of the UC Davis Immune Monitoring Shared Resource and in this capacity, is charged with mentoring young clinical-scientists, especially with regards to clinical trial ancillary study design. An NIH K24 Award will be integral to his future development as a successful mentor to young clinical-investigators. It will ensure that he has protected time to teach and mentor clinical- investigators from various backgrounds to help them obtain research independence. He presents a plan for improving the quality and quantity of his mentoring, including extending his mentoring activities to other academic institutions. In addition, Dr. Maverakis proposes to augment his current patient-oriented-research by designing and conducting early stage clinical studies to explore novel treatments and their biomechanisms.

题目：指导医师科学家进行面向患者的研究

项目成果

Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patients.

• DOI: 10.1111/all.14983
• 发表时间: 2022-03
• 期刊: Allergy
• 影响因子: 12.4
• 作者: Mitamura Y;Schulz D;Oro S;Li N;Kolm I;Lang C;Ziadlou R;Tan G;Bodenmiller B;Steiger P;Marzano A;de Prost N;Caudin O;Levesque M;Stoffel C;Schmid-Grendelmeier P;Maverakis E;Akdis CA;Brüggen MC
• 通讯作者: Brüggen MC

Demographic and Clinical Factors Associated with Patient-Reported Remission in Psoriasis.

• DOI: 10.1007/s13555-022-00692-3
• 发表时间: 2022-03
• 期刊: Dermatology and therapy
• 影响因子: 3.4
• 作者: Gondo G;Hadeler E;Brownstone N;Maverakis E;Merola JF;Armstrong AW;Bhutani T;Bell SJ;Liao W
• 通讯作者: Liao W