UTMB OAIC Clinical Research Resource Core 2 (CRRC2)

UTMB OAIC 临床研究资源核心 2 (CRRC2)

基本信息

批准号：
10670188
负责人：
Elena Volpi
金额：
$ 18.61万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-06-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670188
关键词：
Abbreviations Adipose tissue Aging American Aspirin Behavior Therapy Behavioral Biology Biometry Biopsy Body Composition Capsicum Caring Clinic Clinical Research Clinical Trials Clinical and Translational Science Awards Communities Data Management Resources Development Dietary Intervention Elderly Electronic Health Record Emerging Technologies Ensure Event Exercise Test Failure Goals Health Health Insurance Portability and Accountability Act Healthcare Hispanic Hospitalization Hospitals Individual Infrastructure Intervention Laboratories Laboratory Research Leadership Long-Term Care for Elderly Measurement Medical Metabolism Methodology Methods Molecular Monitor Multi-Institutional Clinical Trial Muscle Nutritional Nutritional status Outcomes Research Participant Pathway interactions Patient Admission Patient-Focused Outcomes Patients Physical Function Physical activity Pilot Projects Policies Population Population Heterogeneity Procedures Productivity Protocols documentation Recovery Recovery of Function Regulation Research Research Personnel Research Support Research Training Resources Risk Reduction Running Safety Standardization Teacher Professional Development Techniques Technology Testing Texas Training Transducers Translating Translational Research Translations Universities Update acute care career development clinical investigation education research education resources ethnic minority population exercise intervention exercise training functional outcomes human subject human subject protection improved innovation investigator training loss of function novel nutrition patient oriented patient safety physically handicapped racial minority population recruit research study retention rate satisfaction screening standardize measure timeline ward working group

项目摘要

PROJECT SUMMARY/ABSTRACT (CRRC2) The UTMB OAIC Clinical Research Resource Core (CRRC2) is the primary resource to support clinical research, including subject recruitment, tracking and retention activities, and investigators’ training. In the new cycle, the core will support research studies on the mechanisms underlying function loss and recovery; development and testing of novel treatments; trajectories of physical function and disability in community- dwelling and hospitalized older adults; and pragmatic, patient-centered studies on recovery from illness. All CRRC2 activities will support the broader OAIC theme: Translate pathways of function loss and gain into interventions to improve functional recovery in diverse geriatric populations. The Specific Aims of the CRRC2 are: 1. Support clinical research relevant to the OAIC theme. 2. Coordinate training in recruitment, retention, and study procedures. 3. Develop novel methods to improve clinical study recruitment, retention and diversity. The CRRC2 has supported over the current cycle translational research in healthy older adults and geriatric patients, including 31 OAIC projects and 43 external projects. Core expertise in muscle biology, metabolism, nutrition, exercise, and behavioral interventions has been instrumental in developing the infrastructure to support translation of basic discoveries in geriatric populations, developing the ACE Unit Functional Laboratory, and participating in large multisite clinical trials. Going forward the CRRC2 will continue to recruit, track and retain diverse older adults for supported projects, including OAIC Network multisite clinical trials; provide standardized health screenings, physical exams, functional, nutritional and body composition assessments, exercise testing and training, and muscle and adipose tissue biopsies; monitor compliance and safety; train investigators; support use of technology in clinical trials; improve methodologies to enhance retention and intervention fidelity; and develop best practices to recruit diverse Hispanic participants in clinical studies. The CRRC2 will continue to enhance the OAIC clinical research quality, efficiency, productivity, and provide developmental opportunities for scholars and other investigators.

项目摘要/摘要（CRRC2） UTMB OAIC临床研究资源核心（CRRC2）是支持临床的主要资源研究，包括受试者招聘，跟踪和保留活动以及研究人员的培训。在新的循环，核心将支持研究有关功能丧失和恢复机制的研究；新疗法的开发和测试；社区中身体机能和残疾的轨迹 - 住宅和住院老年人；以及务实的，以患者为中心的疾病康复研究。全部 CRRC2活动将支持更广泛的OAIC主题：将功能损失的途径转化为采取干预措施，以改善潜水员老年人群的功能恢复。 CRRC2的具体目的是： 1。支持与OAIC主题相关的临床研究。 2。协调招聘，保留和研究程序的培训。 3。开发新的方法来改善临床研究招聘，保留和多样性。 CRRC2在健康的老年人和老年医生的当前周期转化研究中得到了支持患者，包括31个OAIC项目和43个外部项目。肌肉生物学，代谢方面的核心专业知识，营养，锻炼和行为干预措施对开发基础设施有助于支持老年人群中基本发现的翻译，开发ACE单元功能实验室，并参加大型多站点临床试验。展望未来，CRRC2将继续招募，跟踪和留住潜水员老年人，以获得支持的项目，包括OAIC网络多站点临床试验；提供标准化的健康检查，身体检查，功能，营养和身体成分评估，运动测试和训练以及肌肉以及脂肪组织活检；监控合规性和安全性；火车调查人员；支持技术使用临床试验；改善增强保留和干预保真度的方法；并发展最佳实践招募临床研究的各种西班牙裔参与者。 CRRC2将继续增强OAIC 临床研究质量，效率，生产力，并为学者和其他调查人员。