The impact of sensory intervention on motor output and feeding performance in term and preterm infants
The impact of sensory intervention on motor output and feeding performance in term and preterm infants
批准号:
10283252
负责人:
Christopher Mayerl
金额:
$11.4万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-01 至 2022-08-31
关键词:
3-DimensionalAddressAnatomyAnimal ModelAutomobile DrivingBehaviorBiomechanicsBiomimeticsBolus InfusionBrain StemBreastChildChronicComplexCranial NervesDataDeglutitionDeglutition DisordersDevelopmentDiscipline of NursingElectromyographyEnsureEnvironmentEthicsEvidence based interventionExhibitsFacultyFailureFamily suidaeFeedbackFoodFoundationsFundingGenerationsGoalsHospitalizationHumanInfantInterventionLiquid substanceMeasuresMentorsMilkModelingMotorMotor outputMuscleMuscle functionMusculoskeletalMusculoskeletal SystemNatureNeuronal PlasticityNipplesOropharyngealOutcomes ResearchOutputPatientsPerformancePeriodicityPhysiologicalPhysiologyPremature InfantPropertyRadiationResearchResolutionSafetySensorySpeedSuctionSystemTestingTranslatingVariantViscositybasecareerdesignexperienceexperimental studyfeedinggenioglossus muscleimprovedinsightkinematicsneonateneuromuscularnovelprematurepressureprogramsrelating to nervous systemresponsesensory inputtemporal measurementtherapy designtherapy development
中文摘要
婴儿喂养是一种复杂的行为,既需要获得乳汁的能力,也需要运输和排泄的能力
英文摘要
Infant feeding is a complex behavior that requires the ability to both acquire milk, as well as transport and
swallow it. Preterm infants often exhibit a decreased ability to generate suction pressure to acquire milk, and
experience challenges transporting and swallowing milk. Understanding the mechanisms behind these
challenges is difficult due to the complexity of infant feeding as well as the fragile nature of preterm infants.
Feeding is controlled by multiple cranial nerves and over 25 muscles, yet we know little of how those muscles
function due to the ethical and practical restrictions of acquiring data on human infants. Clinicians cannot
control for the degree of prematurity in their patients, cannot measure muscle function accurately or precisely,
and are limited in the temporal resolution of their data, due to radiation from videofluoroscopic swallowing
studies. The objective of this proposal is to use a validated animal model to acquire controlled, high resolution
data to study how term and preterm infants respond to interventions to improve feeding performance during
feeding. This research will combine bi-planar (3D) high speed (100 fps) videofluoroscopy with chronic
indwelling fine-wire electromyography to measure how muscles drive the kinematics, swallow safety, and fluid
dynamics of term and preterm infant feeding. The central hypothesis is that term infants will show higher
levels of pressure generation and ability to transport viscous fluids, but that the plastic neural system of
preterm infants will enable them to exhibit a greater response to increases in pressure generation requirements
and increases in viscosity. First, I will measure how the musculoskeletal system responds to changes in
pressure generation requirements to acquire food in term and preterm infant pigs (SA1-K99), and then
measure the neuromotor response to changes in viscosity in term and preterm infant pigs (SA2-K99).
Following these, I will measure neuromotor function of term and preterm infants when feeding on a
biomimetic nipple, compared to those currently available commercially (SA3-R00).This research will provide
insight into the mechanisms driving feeding performance in infants and provide a foundation for developing
interventions based off physiologic, rather than qualitative, indications of poor performance for patients with
dysphagia. This is significant because it represents an important advance in the basic understanding of the
mechanisms of infant feeding, and mechanisms of failure. As such these results will be the foundation for
evidence-based interventions for neonate dysphagia. This project will directly advance my career goals to
establish a federally funded research program grounded in understanding normal and pathophysiologic
sensorimotor integration. NEOMED is an excellent environment for me to develop this research program, as
there are an array of faculty within the department that conduct cutting edge research on musculoskeletal
function, in addition to my research mentor, whom is an expert in the field of infant dysphagia.
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DOI:
10.1002/jez.2657
发表时间:
2023-01
期刊:
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
影响因子:
2.8
作者:
[Adjerid, Khaled, Johnson, Maxwell L., Edmonds, Chloe E., Steer, Kenall E., Gould, Francois D. H., German, Rebecca Z., Mayerl, Christopher J.]
通讯作者:
Mayerl, Christopher J.
Anatomical and physiological variation of the hyoid musculature during swallowing in infant pigs.
仔猪吞咽过程中舌骨肌肉组织的解剖和生理变化。
DOI:
10.1242/jeb.243075
发表时间:
2021
期刊:
The Journal of experimental biology
影响因子:
--
作者:
[Mayerl,ChristopherJ, Steer,KendallE, Chava,AlmasiM, Bond,LauraE, Edmonds,ChloeE, Gould,FrancoisDH, Hieronymous,TobinL, Vinyard,ChristopherJ, German,RebeccaZ]
通讯作者:
German,RebeccaZ
The Function of the Mammal Extrinsic Tongue Musculature in the Transition from Suckling to Drinking.
哺乳动物外在舌头肌肉组织在从哺乳到饮水过渡中的功能。
DOI:
10.1093/icb/icad023
发表时间:
2023
期刊:
Integrative and comparative biology
影响因子:
2.6
作者:
[Steer,KE, Johnson,ML, Adjerid,K, Bond,LE, Howe,SP, Khalif,A, Nkachukwu,KC, Edmonds,CE, German,RZ, Mayerl,CJ]
通讯作者:
Mayerl,CJ
DOI:
10.1111/jtxs.12599
发表时间:
2021-12
期刊:
JOURNAL OF TEXTURE STUDIES
影响因子:
3.2
作者:
[Mayerl, Christopher J., Edmonds, Chloe E., Gould, Francois D. H., German, Rebecca Z.]
通讯作者:
German, Rebecca Z.
The Pathway from Anatomy and Physiology to Diagnosis: A Developmental Perspective on Swallowing and Dysphagia.
从解剖学和生理学到诊断的途径:吞咽和吞咽困难的发展视角。
DOI:
10.1007/s00455-022-10449-x
发表时间:
2023
期刊:
Dysphagia
影响因子:
2.6
作者:
[Mayerl,CJ, Gould,FDH, Adjerid,K, Edmonds,C, German,RZ]
通讯作者:
German,RZ
The impact of biomimetic nipple on infant feeding function
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批准号:10671740
-
项目类别:
-
资助金额:$23.75万
-
财政年份:2022
-
负责人:Christopher Mayerl
-
依托单位:
The impact of biomimetic nipple on infant feeding function
-
批准号:10662633
-
项目类别:
-
资助金额:$24.89万
-
财政年份:2022
-
负责人:Christopher Mayerl
-
依托单位:
海外基金