Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics

非洲裔美国人和西班牙裔美国人急性胰腺炎导致糖尿病的机制 急性胰腺炎(AP)导致氧化和炎症损伤，继而导致实质损伤、外分泌 和/或内分泌不足，包括糖尿病的发展。而急性呼吸道合并症增加了 糖尿病的发展，糖尿病的类型，无论是1型糖尿病(T1D，自身免疫性)与其他 糖尿病的形式，尚不清楚。考虑到糖尿病是我国的一大健康差距，理解 在不同种族的人群中，AP引发的糖尿病是必要的。此外，风险因素或机制 导致AP引发的糖尿病的原因也不清楚。重要的是，肠道微生物区系是与疾病发生有关的新因素。 在T1D和2型糖尿病(T2D)中，其在AP驱动的糖尿病中的作用尚不清楚。此外，在我们多样化的 在患者群体中，肠道微生物区系的组成特征没有得到很好的定义。我们的提案充分利用了我们的 广泛、多机构的患者队列，主要是非洲裔美国人(AA)和西班牙裔美国人 和我们广泛的多学科团队，在临床胰腺学和糖尿病，肠道方面拥有广泛的专业知识 微生物组、饮食和健康差异研究。总而言之，我们建议的目标有三个：1)在 我们多样化的患者群体，主要是AA和西班牙裔，AP与T1D之间的关系，以及 其他形式的糖尿病，以及与糖尿病发展相关的因素，并从机械上定义 2)特别富含动物蛋白质和脂肪的饮食(DH-APF)如何通过其与肠道的相互作用 微生物区系，影响AP驱动的糖尿病，以及3)饮食中的纤维如何通过短链的产生 脂肪酸(SCFAs)是最近在T1D和T2D的发生中被发现的一个因素，它介导AP驱动 T1D。

Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics Acute pancreatitis (AP) leads to oxidative and inflammatory injury, ensuing parenchymal damage, exocrine and/or endocrine insufficiencies including the development of diabetes. While AP increases the risk of the development of diabetes, the type of diabetes, either type 1 diabetes (T1D, autoimmune) as compared to other forms of diabetes, is not clear. Considering diabetes is a major health disparity in our country, understanding AP-driven diabetes is needed in racially diverse populations. Additionally, the risk factors or the mechanisms lead to AP driven diabetes is also unclear. Importantly, the gut microbiota is a novel factor linked to the genesis of both T1D and type 2 diabetes (T2D), yet its role in AP driven diabetes is not known. Moreover, in our diverse patient population, the compositional profiles of gut microbiota are not well defined. Our proposal leverages our extensive, multiple institutional, cohort of patients which is predominantly African American (AA) and Hispanic and our broad, multidiscplinary team with a range of expertise in clinical pancreatology and diabetes, gut microbiome, diet and health disparities research. In sum, the goal of our proposal is three-fold: 1) to define in our diverse patient population that is predominantly AA and Hispanic, the relationship between AP to T1D, and other forms of diabetes, and the factors associated with development of diabetes, and to mechanistically define 2) how diet, specifically enriched in animal protein and fat (DH-APF), through its interaction with the gut microbiota, impacts AP-driven diabetes, and 3) how fiber from the diet, through the generation of short chain fatty acids (SCFAs), a recently recognized factor identified in the genesis of T1D and T2D, mediates AP-driven T1D.