Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics

非裔美国人和西班牙裔人急性胰腺炎导致糖尿病的机制

基本信息

批准号：
10265550
负责人：
Brian Thomas Layden
金额：
$ 24.93万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10265550
关键词：
African American Animals Autoimmune B-Lymphocytes Bacteria Cell physiology Chicago Clinical Consumption Country County Data Data Set Development Diabetes Mellitus Diet Dietary Fiber Disease Endocrine Energy-Generating Resources Environment Environmental Risk Factor Etiology Fatty acid glycerol esters Feces Fiber General Population Generations Genes Goals Hispanics Hydrogen Sulfide Immunologics Individual Inflammatory Injury Insulin Resistance Insulin-Dependent Diabetes Mellitus Intake Lead Link Longitudinal cohort Measures Meat Mediating Mediation Metabolic Minority Groups Modeling Morbidity - disease rate Nature Non-Insulin-Dependent Diabetes Mellitus Not Hispanic or Latino Nutrient Pancreatitis Pathway interactions Patients Population Heterogeneity Prevention strategy Production Proteins Research Risk Risk Factors Role Sampling Serum Sulfur Metabolism Pathway Sum Time Translations United States Volatile Fatty Acids acute pancreatitis base clinical center cohort cooking defined contribution diabetes risk dietary ethnic diversity gut microbiome gut microbiota health disparity high risk immunoregulation improved in vivo Model member microbial microbiome mortality multidisciplinary novel novel marker patient population racial diversity treatment strategy

项目摘要

Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics Acute pancreatitis (AP) leads to oxidative and inflammatory injury, ensuing parenchymal damage, exocrine and/or endocrine insufficiencies including the development of diabetes. While AP increases the risk of the development of diabetes, the type of diabetes, either type 1 diabetes (T1D, autoimmune) as compared to other forms of diabetes, is not clear. Considering diabetes is a major health disparity in our country, understanding AP-driven diabetes is needed in racially diverse populations. Additionally, the risk factors or the mechanisms lead to AP driven diabetes is also unclear. Importantly, the gut microbiota is a novel factor linked to the genesis of both T1D and type 2 diabetes (T2D), yet its role in AP driven diabetes is not known. Moreover, in our diverse patient population, the compositional profiles of gut microbiota are not well defined. Our proposal leverages our extensive, multiple institutional, cohort of patients which is predominantly African American (AA) and Hispanic and our broad, multidiscplinary team with a range of expertise in clinical pancreatology and diabetes, gut microbiome, diet and health disparities research. In sum, the goal of our proposal is three-fold: 1) to define in our diverse patient population that is predominantly AA and Hispanic, the relationship between AP to T1D, and other forms of diabetes, and the factors associated with development of diabetes, and to mechanistically define 2) how diet, specifically enriched in animal protein and fat (DH-APF), through its interaction with the gut microbiota, impacts AP-driven diabetes, and 3) how fiber from the diet, through the generation of short chain fatty acids (SCFAs), a recently recognized factor identified in the genesis of T1D and T2D, mediates AP-driven T1D.

非洲裔美国人和西班牙裔急性胰腺炎的糖尿病机制急性胰腺炎（AP）导致氧化和炎症性损伤，随之而来的实质损害，外分泌和/或内分泌不足，包括糖尿病的发展。而AP增加了与其他糖尿病的形式尚不清楚。考虑糖尿病是我国的主要健康差异，理解在种族多样化的种群中，需要AP驱动的糖尿病。此外，风险因素或机制导致AP驱动的糖尿病也不清楚。重要的是，肠道菌群是与创世纪有关的新因素在T1D和2型糖尿病（T2D）中，其在AP驱动糖尿病中的作用尚不清楚。而且，在我们的多样患者群体，肠道菌群的组成谱尚未很好地定义。我们的建议利用我们的广泛的，多个机构的，主要是非裔美国人（AA）和西班牙裔的患者队列以及我们广泛的多学院团队，具有临床胰腺学和糖尿病方面的专业知识，肠道微生物组，饮食和健康差异研究。总而言之，我们的提议的目标是三个：1）定义我们多样化的患者人群主要是AA和西班牙裔，AP与T1D之间的关系以及其他形式的糖尿病以及与糖尿病发展相关的因素，并定义 2）如何通过与肠道相互作用，特别丰富动物蛋白和脂肪（DH-APF）的饮食微生物群，影响AP驱动的糖尿病，3）饮食的纤维如何通过短链产生脂肪酸（SCFA）是T1D和T2D的起源中鉴定出的最近公认的因子，可介导AP驱动 T1D。