A Novel DHA Treatment Approach for Alzheimer's Disease
A Novel DHA Treatment Approach for Alzheimer's Disease
批准号:
10082124
负责人:
Brian Thomas Layden
金额:
$34.96万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-09-15 至 2022-08-31
关键词:
AddressAge-associated memory impairmentAgingAgreementAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer&aposs disease related dementiaAmericanBehavioralBiochemicalBlood - brain barrier anatomyBrainCertificationChemicalsChicagoClinical TrialsCollaborationsControl GroupsCyclic GMPDataDementiaDevelopmentDocosahexaenoic AcidsDrug Delivery SystemsEicosapentaenoic AcidElderlyEuphausiaceaFailureFish OilsFutureGenetic ModelsGoalsHumanIllinoisIndustryLeadLicensingLipaseLongevityLysophospholipidsMarketingMeasuresMemoryMemory LossMetabolicMusNatural ProductsOilsOmega-3 Fatty AcidsOutcomePeripheralPhasePopulationPreventionPreventivePreventive measurePreventive treatmentProcessProductionResearchSeriesTechniquesTestingTissuesTriglyceridesUniversitiesage relatedaging populationanalytical methodcognitive functioncommercializationdementia riskdietary supplementsearly onsetefficacy testingepidemiology studyexperienceexperimental studyfunctional declineimprovedinnovationmouse modelnovelnovel strategiesphase 2 studypreventprocess optimizationresearch and developmenttreatment effect
中文摘要
阿尔茨海默病(AD)和相关的痴呆症(ADRD)对健康产生不利影响
英文摘要
Alzheimer’s disease (AD) and related dementia (ADRD) are adversely impacting the healthy
lifespan in our aging population. Fish oil has been suggested to improve AD/ADRD outcomes.
The omega 3 fatty acids (Om3FA) in fish oil in particular DHA (docosahexaenoic acid) is a key
molecule. Some data exists that DHA is beneficial for protection against age related cognitive
decline and related dementia such as AD. However, current dietary supplements of Om3FA do
not appreciably increase DHA levels in the brain. Our data explains why multiple human clinical
trials failed with DHA treatment for preventing and/or treating AD/ADRD. We have discovered
that this failure to cross the blood-brain barrier is because the Om3FA from these supplements
are absorbed in the form of triacylglycerols, whereas the specific transporter (called Mfsd2a) at
the blood brain barrier requires a lysophospholipid (LPC) form of DHA. Because of this, when we
treat with lipase, it results in the LPC form of DHA. Then, when we treat mice with this form, mice
have a substantial enrichment of the brain DHA, as compared to control group and a notable
memory benefit. Thus, the goal of this phase 1 is to test if LPC-DHA effects memory in AD mouse
models. We will specifically explore the behavioral and biochemical effects of this treatment
approach. Through collaboration with the University of Illinois at Chicago, with expertise in
Om3FA and mouse models, and our expertise in chemical separation and Om3FA isolation
techniques, we are poised to test the efficacy of this novel treatment. Moreover, we are prepared
for Phase 2 studies, which will focus on development of pilot scale production/isolation processes of this
modified DHA. This will eventually lead to marketing and commercialization to protect and/or prevent
against AD development in Phase 3.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics
-
批准号:10461069
-
项目类别:
-
资助金额:$24.06万
-
财政年份:2020
-
负责人:Brian Thomas Layden
-
依托单位:
Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics
-
批准号:10513167
-
项目类别:
-
资助金额:$11.79万
-
财政年份:2020
-
负责人:Brian Thomas Layden
-
依托单位:
Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics
-
批准号:10449719
-
项目类别:
-
资助金额:$11.79万
-
财政年份:2020
-
负责人:Brian Thomas Layden
-
依托单位:
Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics
-
批准号:10671693
-
项目类别:
-
资助金额:$23.95万
-
财政年份:2020
-
负责人:Brian Thomas Layden
-
依托单位:
Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics
-
批准号:10265550
-
项目类别:
-
资助金额:$24.93万
-
财政年份:2020
-
负责人:Brian Thomas Layden
-
依托单位:
Role of Nutrient Sensing Receptors for the Gut Microbiota in Metabolism
-
批准号:10535442
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2017
-
负责人:Brian Thomas Layden
-
依托单位:
A Novel Relationship Between the Gut Microbiota and Pancreatic Beta Cells contributes to Gestational Glucose Homeostasis
-
批准号:9898235
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2017
-
负责人:Brian Thomas Layden
-
依托单位:
A Novel Relationship Between the Gut Microbiota and Pancreatic Beta Cells contributes to Gestational Glucose Homeostasis
-
批准号:9349855
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2017
-
负责人:Brian Thomas Layden
-
依托单位:
Role of Nutrient Sensing Receptors for the Gut Microbiota in Metabolism
-
批准号:10364023
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2017
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:10119096
-
项目类别:
-
资助金额:$67.83万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:10606087
-
项目类别:
-
资助金额:$22.44万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:10671081
-
项目类别:
-
资助金额:$85.01万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:10376575
-
项目类别:
-
资助金额:$33.67万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:9425252
-
项目类别:
-
资助金额:$65.21万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:10262968
-
项目类别:
-
资助金额:$66.61万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:10445345
-
项目类别:
-
资助金额:$65.85万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:9027621
-
项目类别:
-
资助金额:$64.25万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
-
批准号:9757758
-
项目类别:
-
资助金额:$63.52万
-
财政年份:2015
-
负责人:Brian Thomas Layden
-
依托单位:
Role of Short Chain Fatty Acids and their Receptors in Islet Function
-
批准号:8413396
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2012
-
负责人:Brian Thomas Layden
-
依托单位:
Role of Short Chain Fatty Acids and their Receptors in Islet Function
-
批准号:8246647
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2012
-
负责人:Brian Thomas Layden
-
依托单位:
海外基金