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Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics

非裔美国人和西班牙裔人急性胰腺炎导致糖尿病的机制

基本信息

批准号：
10449719
负责人：
Brian Thomas Layden
金额：
$ 11.79万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10449719
关键词：
African American Animals Autoimmune B-Lymphocytes Bacteria Cell physiology Chicago Clinical Consumption Country County Data Data Set Development Diabetes Mellitus Diet Dietary Fiber Disease Endocrine Energy-Generating Resources Environment Environmental Risk Factor Etiology Fatty acid glycerol esters Feces Fiber General Population Generations Genes Goals Hispanics Hydrogen Sulfide Immunologics Individual Inflammatory Injury Insulin Resistance Insulin-Dependent Diabetes Mellitus Intake Lead Link Longitudinal cohort Measures Meat Mediating Mediation Metabolic Minority Groups Modeling Morbidity - disease rate Nature Non-Insulin-Dependent Diabetes Mellitus Not Hispanic or Latino Nutrient Pancreatitis Pathway interactions Patients Population Heterogeneity Prevention strategy Production Proteins Research Risk Risk Factors Role Sampling Serum Sulfur Metabolism Pathway Sum Time Translations United States Volatile Fatty Acids acute pancreatitis base clinical center cohort cooking defined contribution diabetes risk dietary ethnic diversity gut microbiome gut microbiota health disparity high risk immunoregulation improved in vivo Model member microbial microbiome mortality multidisciplinary novel novel marker patient population racial diversity treatment strategy

项目摘要

Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics Acute pancreatitis (AP) leads to oxidative and inflammatory injury, ensuing parenchymal damage, exocrine and/or endocrine insufficiencies including the development of diabetes. While AP increases the risk of the development of diabetes, the type of diabetes, either type 1 diabetes (T1D, autoimmune) as compared to other forms of diabetes, is not clear. Considering diabetes is a major health disparity in our country, understanding AP-driven diabetes is needed in racially diverse populations. Additionally, the risk factors or the mechanisms lead to AP driven diabetes is also unclear. Importantly, the gut microbiota is a novel factor linked to the genesis of both T1D and type 2 diabetes (T2D), yet its role in AP driven diabetes is not known. Moreover, in our diverse patient population, the compositional profiles of gut microbiota are not well defined. Our proposal leverages our extensive, multiple institutional, cohort of patients which is predominantly African American (AA) and Hispanic and our broad, multidiscplinary team with a range of expertise in clinical pancreatology and diabetes, gut microbiome, diet and health disparities research. In sum, the goal of our proposal is three-fold: 1) to define in our diverse patient population that is predominantly AA and Hispanic, the relationship between AP to T1D, and other forms of diabetes, and the factors associated with development of diabetes, and to mechanistically define 2) how diet, specifically enriched in animal protein and fat (DH-APF), through its interaction with the gut microbiota, impacts AP-driven diabetes, and 3) how fiber from the diet, through the generation of short chain fatty acids (SCFAs), a recently recognized factor identified in the genesis of T1D and T2D, mediates AP-driven T1D.

非洲裔美国人和西班牙裔美国人急性胰腺炎与糖尿病的关系急性胰腺炎（AP）导致氧化和炎症损伤，继而导致实质损伤、外分泌损伤和胰腺炎。和/或内分泌失调，包括糖尿病的发展。虽然AP增加了糖尿病的发展，糖尿病的类型，1型糖尿病（T1 D，自身免疫性）与其他糖尿病的类型尚不清楚。考虑到糖尿病是我国主要的健康差距， AP驱动的糖尿病需要在种族多样化的人群中。此外，风险因素或机制导致AP驱动的糖尿病也不清楚。重要的是，肠道微生物群是一个与遗传相关的新因素。 T1 D和2型糖尿病（T2 D），但其在AP驱动的糖尿病中的作用尚不清楚。此外，在我们多样化的在患者群体中，肠道微生物群的组成概况没有很好地定义。我们的建议利用我们的广泛的多机构患者队列，主要是非洲裔美国人（AA）和西班牙裔我们广泛的多学科团队在临床胰腺病学和糖尿病，肠道，微生物组、饮食和健康差异研究。总之，我们的建议有三个目标：1）在我们多样化的患者人群主要是AA和西班牙裔，AP与T1 D之间的关系，其他形式的糖尿病，以及与糖尿病发展相关的因素，并从机制上定义 2)如何饮食，特别是富含动物蛋白质和脂肪（DH-APF），通过其与肠道的相互作用，微生物群，影响AP驱动的糖尿病，以及3）如何从饮食纤维，通过产生短链脂肪酸（SCFAs）是最近发现的在T1 D和T2 D发生中的因子，其介导AP驱动的 T1D