Expanding Translational Research in Arkansas

扩大阿肯色州的转化研究

• 批准号: 10672218
• 负责人: Laura P James
• 金额: $ 426.9万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10672218
• 关键词: Address; African American; Area; Arkansas; Cardiovascular Diseases; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communities; Complex; Death Rate; Diabetes Mellitus; Ecosystem; Environment; Faculty; Fostering; Foundations; Future; Growth; Health; Health Benefit; Healthcare; Healthcare Systems; Home; Individual; Informatics; Institution; Interdisciplinary Study; Intervention; Knowledge; Lead; Link; Longevity; Measurable; Medical; Methods; Minority Groups; Mission; Obesity; Pediatric Hospitals; Population; Positioning Attribute; Poverty; Process; Research; Research Institute; Research Methodology; Research Personnel; Research Support; Research Training; Resistance; Resources; Rewards; Rural; Rural Population; Science; Site; Training; Training and Education; Translational Research; Underrepresented Populations; Universities; Veterans; Vision; Work; career; career development; community engagement; health care disparity; improved; innovation; metropolitan; novel strategies; programs; rural area; success; translational scientist

Contact PD/PI: James, Laura P PROJECT SUMMARY Overall The health challenges of Arkansas mandate that the University of Arkansas for Medical Sciences (UAMS) Translational Research Institute (TRI) works in partnership with communities and stakeholders to develop and conduct clinical and translational research (CTR) that will measurably improve the health of Arkansans. As the academic home for translational researchers, our Clinical and Translational Science Award (CTSA) hub has developed efficient and resourceful workflows, established excellent research training and educational programs, and launched initiatives to support the growth of team science and community engagement. With maturation of our hub, we have expanded our integration with our participating sites, Arkansas Children’s Hospital (ACH) and the Central Arkansas Veteran’s Healthcare System (CAVHS), which provides us with diverse perspectives and a collaborative foundation of multidisciplinary research across these three closely- linked institutions. Collectively, hub faculty from UAMS, ACH, and CAVHS have rich expertise in CTR engaging rural and underrepresented populations and will help us expand CTR resources more broadly. Our vision is to be a thriving translational research ecosystem that catalyzes discoveries into health solutions for rural and underrepresented populations. Our future work, based on our previous accomplishments, will be guided by the following five specific aims: Aim 1). Enrich our environment for CTR by supporting and rewarding team-based collaborations at the local and national level; Aim 2). Enhance training to researchers across the translational research spectrum and at all career levels through innovative and team-based approaches; Aim 3). Increase partnerships with diverse stakeholders to expand the impact of clinical and translational research in and with rural populations; Aim 4). Streamline translational research processes and enhance research quality with state-of-the-art informatics approaches and methods; and Aim 5). Expand clinical and translational research opportunities across the lifespan and in underrepresented populations. The collective impact of our success as a CTSA hub will provide “real world solutions” for effective CTR in rural and underrepresented populations, a facet insufficiently represented within the CTSA Consortium. Page 303 Project Summary/Abstract Contact PD/PI: James, Laura P

联系人 PD/PI：James、Laura P 项目概要 全面的 阿肯色州的健康挑战要求阿肯色医学大学 (UAMS) 转化研究所 (TRI) 与社区和利益相关者合作开发和 进行临床和转化研究（CTR），以显着改善阿肯色州人的健康。作为 我们的临床和转化科学奖 (CTSA) 中心是转化研究人员的学术家园 开发高效且资源丰富的工作流程，建立优秀的研究培训和教育 计划，并发起了支持团队科学和社区参与发展的举措。和 随着我们中心的成熟，我们扩大了与参与地点阿肯色州儿童医院的整合 医院 (ACH) 和阿肯色州中部退伍军人医疗保健系统 (CAVHS)，它为我们提供了 不同的观点和跨这三个密切相关的多学科研究的协作基础 关联机构。总的来说，来自 UAMS、ACH 和 CAVHS 的中心教师在 CTR 方面拥有丰富的专业知识 吸引农村和代表性不足的人群，并将帮助我们更广泛地扩大 CTR 资源。我们的 愿景是成为一个蓬勃发展的转化研究生态系统，将发现转化为健康解决方案 农村和代表性不足的人口。我们未来的工作将基于我们之前的成就 遵循以下五个具体目标： 目标 1)。通过支持和奖励来丰富我们的点击率环境 地方和国家层面的基于团队的合作；目标2）。加强对整个研究人员的培训 通过创新和基于团队的方法，在所有职业层面进行转化研究；目的 3）。加强与不同利益相关者的合作伙伴关系，以扩大临床和转化研究的影响 在农村人口中以及与农村人口一起；目标 4)。简化转化研究流程并加强研究 采用最先进的信息学方法和方法来保证质量；和目标 5)。扩大临床和转化 整个生命周期和代表性不足的人群的研究机会。我们的集体影响 作为 CTSA 中心的成功将为农村和代表性不足的地区有效的点击率提供“现实世界的解决方案” CTSA 联盟中代表性不足的一个方面。 第303页 项目概要/摘要 联系人 PD/PI：James、Laura P

项目成果

Qualitative content analysis of public responses to an FDA inquiry on the impact of scheduling changes to kratom.

• DOI: 10.1016/j.drugpo.2022.103817
• 发表时间: 2022-10
• 期刊: INTERNATIONAL JOURNAL OF DRUG POLICY
• 影响因子: 4.4
• 作者: Tobacyk, Julia;Parks, Brian J.;Lovelady, Nakita;Brents, Lisa K.
• 通讯作者: Brents, Lisa K.

Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson's disease.

• DOI: 10.1038/s41598-022-07994-8
• 发表时间: 2022-03-09
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Syeda HB;Glover A;Pillai L;Kemp AS;Spencer H;Lotia M;Larson-Prior LJ;Virmani T
• 通讯作者: Virmani T

Trusted Sources of COVID-19 Vaccine Information among Hesitant Adopters in the United States.

在美国犹豫的采用者中，可信赖的Covid-19疫苗信息来源。

• DOI: 10.3390/vaccines9121418
• 发表时间: 2021-12-01
• 期刊: Vaccines
• 影响因子: 7.8
• 作者: Purvis RS;Hallgren E;Moore RA;Willis DE;Hall S;Gurel-Headley M;McElfish PA
• 通讯作者: McElfish PA

Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma.

正常和癌症成纤维细胞在皮肤T细胞淋巴瘤中差异调节Twist1，Tox和细胞因子基因表达。

• DOI: 10.1186/s12885-021-08142-7
• 发表时间: 2021-05-03
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Mehdi SJ;Moerman-Herzog A;Wong HK
• 通讯作者: Wong HK

Anxiety, depressive, and trauma symptoms during the COVID-19 pandemic: Evaluating the role of disappointment with God.

焦虑，抑郁症和创伤症状在19日大流行期间：评估对上帝失望的作用。

• DOI: 10.1016/j.jad.2021.06.045
• 发表时间: 2021-10-01
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Sherman AC;Park CL;Salsman JM;Williams ML;Amick BC;Hudson TJ;Messias EL;Simonton-Atchley S
• 通讯作者: Simonton-Atchley S