Developing a Framework to Advance Cultural Sensitivity and Accommodate Behavioral Variability in Toddler Autism Screening: A Mixed-Methods Cross-Cultural Approach to Improve Autism Screening Accuracy
制定一个框架,以提高幼儿自闭症筛查中的文化敏感性并适应行为变异性:提高自闭症筛查准确性的混合方法跨文化方法
基本信息
- 批准号:10676552
- 负责人:
- 金额:$ 5.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-16 至 2026-06-15
- 项目状态:未结题
- 来源:
- 关键词:AfricanAgeAlgorithmsAttenuatedBehaviorBehavioralBrainCaregiversCaringCharacteristicsChildClinicalCultural SensitivityData AnalyticsData CollectionDetectionDevelopmentDevelopmental Delay DisordersDiagnosisDiagnosticEcological momentary assessmentEquityEthnic PopulationExhibitsFacial ExpressionFamilyFutureGroup AffiliationHeterogeneityIndividualIndividual DifferencesInequityLifeMachine LearningMeasuresMethodsMiddle EasternMonitorNursery SchoolsOutcomeParentsPerceptionPlayPopulationRecommendationReportingResearchSamplingSchool-Age PopulationScientistScreening procedureServicesSocial DevelopmentSocioeconomic StatusSpecialistSpecificityTechniquesTimeToddlerTrainingUnited StatesVariantalgorithm developmentautism spectrum disorderautistic childrencommunication behaviorcostdesigndisorder riskeconomic needethnic minorityexpectationhuman old age (65+)improvedminority childrennovelphenomenological modelsprediction algorithmprospectiveprototyperacial minorityracial populationscreeningskillssocial communication
项目摘要
PROJECT SUMMARY
Autism Spectrum Disorder (ASD) is a prevalent, lifelong condition that manifests early in life and is associated
with significant social communication challenges1–3 and economic needs1 for children with ASD and their
families. Access to early, ASD-specific services can profoundly improve long-term outcomes for children with
ASD4–9 and depends on timely detection of the condition. However, the predictive accuracy of ASD screening
is well below recommended standards for screening tools10,15,21 and is even lower for racial and ethnic minority
children10,31–38 when compared to White children. Screening tools, which typically rely on parental report, may
lack predictive accuracy because they do not sufficiently account for heterogeneity between and within
cultural groups. Variation in culture-based parental perception of early ASD expressions has been noted
between groups29,46–51, and some social communication behaviors used in ASD screening perform significantly
differently between racial and ethnic groups31,32,36–38. Additionally, existing phenomenological heterogeneity has
been observed via clinicians in the development of social communication emergence across prodromal
individuals44, 53–58 within cultural groups. However, current screeners employ methods that do not sufficiently
capture this existing heterogeneity, and this heterogeneity has not been precisely characterized as
prospectively observed and reported by caregivers. Therefore, it remains difficult to develop new parent-report
screeners designed to account for heterogeneity in developmental trajectories in an informed way.
The primary objective of this proposal is to develop and assess a framework for developing culturally-sensitive
and highly predictive parental-report screening measures to improve the equity and accuracy of future ASD
screeners for use with diverse families. This will be achieved by i) developing culturally-sensitive ASD
screening items; ii) using these items in data collection via ecological momentary assessment (EMA); and iii)
employing Machine Learning (ML) to develop prototype algorithms that maximize ASD prediction between and
within different cultural groups. EMA provides real-time in-context monitoring at time-periods proximal to target
dynamics60–62. EMA is therefore an ideal choice to capture the heterogeneity in developmental trajectories of
social-communication behaviors over time as observed and reported by caregivers. ML develops prediction
algorithms that can differentially weigh and combine ASD indicators based on group affiliation, individual
differences, and temporal specificity and is an optimal approach for algorithm development in the presence of
developmental heterogeneity76 but is underutilized in ASD screening efforts77. Through the proposed research
and training plan, the applicant will develop the skills and expertise needed to make a substantive contribution
to ASD research as an independent clinical scientist.
项目摘要
自闭症谱系障碍(ASD)是一种普遍的终身疾病,在生命早期表现出来,
患有ASD的儿童面临重大的社会沟通挑战1 -3和经济需求1,
家庭获得早期的ASD特异性服务可以大大改善患有ASD的儿童的长期结果。
ASD 4 -9,并依赖于及时检测的条件。然而,ASD筛查的预测准确性
远低于筛查工具的推荐标准10,15,21,对于种族和少数民族甚至更低
与白色儿童相比,儿童10岁,31-38岁。筛查工具通常依赖于父母的报告,
缺乏预测准确性,因为它们不能充分说明内部和之间异质性
文化群体。已经注意到基于培养的父母对早期ASD表达的感知的变化
在组29,46-51之间,ASD筛查中使用的一些社交行为表现显著
differently不同between种族and ethnic种族groups 31,32,36-38.此外,现有的现象学异质性
通过临床医生观察到,在前驱期的社会沟通出现的发展中,
individuals44,53-58 within cultural groups.然而,目前的筛选采用的方法不足以
捕捉这种现有的异质性,这种异质性并没有被精确地描述为
前瞻性观察和报告的照顾者。因此,开发新的家长报告仍然很困难
筛选器旨在以知情的方式解释发展轨迹的异质性。
这项建议的主要目标是制定和评估一个框架,
和高度预测性的父母报告筛查措施,以提高未来ASD的公平性和准确性
用于不同家庭的筛选器。这将通过以下方式实现:i)开发对文化敏感的ASD
筛选项目; ii)通过生态瞬时评估(EMA)在数据收集中使用这些项目;以及iii)
采用机器学习(ML)开发原型算法,最大限度地提高和之间的ASD预测
在不同的文化群体中。EMA在接近目标的时间段内提供实时背景监测
动力学60 -62.因此,EMA是捕捉发育轨迹异质性的理想选择,
社会交往行为随着时间的推移,观察和报告的照顾者。ML开发预测
算法,可以有区别地衡量和联合收割机ASD指标的基础上,组的隶属关系,个人
差异,和时间特异性,是算法开发的最佳方法,
发育异质性76,但在ASD筛查工作中未得到充分利用77。通过拟议的研究
和培训计划,申请人将发展所需的技能和专业知识,作出实质性的贡献
作为一名独立的临床科学家参与ASD研究
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Shana M Attar其他文献
Shana M Attar的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
- 批准号:
DP240103257 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
- 批准号:
DP240100408 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
- 批准号:
DP240100111 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
- 批准号:
502786 - 财政年份:2024
- 资助金额:
$ 5.02万 - 项目类别:
Directed Grant