Next-Gen Oncopathology Program

下一代肿瘤病理学计划

• 批准号: 10676213
• 负责人: ETHEL CESARMAN
• 金额: $ 36.18万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676213
• 关键词: programs

The Next-Gen Oncopathology (NGO) program has the overall mission of training young diagnosticians to meet advances in our understanding of the mechanisms of cancer pathogenesis and new oncological interventional approaches thereby leading the field of pathology into the future. Specialized pathologists have been involved in cancer diagnostics by examining tissues and other specimens since at least the 19th century, and training in pathology has been incrementally structured and subspecialized. Pathology training programs traditionally teach residents to examine tissue under the microscope and analyze laboratory data for diagnosis, with pathology research being largely descriptive. This approach is no longer sufficient, and it is essential that we prepare pathologists to understand and apply advanced technologies to perform more precise and personalized diagnostics in addition to utilizing innovative and improved ways to conduct research and diagnose cancer. The Weill Cornell Department of Pathology and Laboratory Medicine has trained numerous outstanding pathologists in many subspecialty areas, but it is only with the use of an innovative approach incorporating a view towards the future that we will be able to produce leaders that will advance the field of cancer pathology. The NGO program takes a holistic and multidisciplinary approach, where all aspects of a cancer patient are considered, ranging from the tumors themselves, to in vitro and in vivo cancer models, to changes in the patients’ blood and microbial infections. Thus, trainees in both Anatomic and Clinical Pathology (i.e. Laboratory Medicine) will be included, which will be individuals with MD or MD/PhD degrees doing a Pathology Residency or Fellowship, or trainees with PhD degrees doing a clinical fellowship in Laboratory Medicine, who are committed to an academic career that includes cancer research. Our trainees will gain expertise and depth by spending two years in a research laboratory working in one or more of the following major themes: 1) molecular diagnosis and cellular therapies, 2) cancer pathobiology, 3) advanced imaging and 4) tumor microenvironment. The foundational principles of the NGO program will be to ensure that all the pathology projects relate to the study of cancer patient samples as well as the comparative pathology of cancer models. Overarching methodologies that will support all of the projects are: i) biostatistics and data science, ii) machine learning and artificial intelligence, and iii) genomics, epigenomics, proteomics and metabolomics. Faculty in the program have expertise in the major themes and specific methodologies, which will allow for the teaching of foundational skills as well as a highly customized educational plan. This will be accomplished by the establishment of a mandatory NGO Course as well as additional course requirements on data science and career development, which will allow trainees flexibility to design a personalized curriculum with their mentoring committee. We will also leverage the Meyer Cancer Center and the Weill Cornell Clinical and Translational Science Center (CTSC) resources to educate the next generation of pathologists working on cancer.

下一代肿瘤病理学（NGO）计划的总体使命是培训年轻诊断医生见面 我们对癌症发病机理和新肿瘤学介入机制的理解的进步 因此，将病理领域带入未来。专门的病理学家参与了 在癌症诊断中，至少从19世纪开始检查组织和其他标本，并培训 病理已逐渐结构和分泌。病理培训计划传统教学 居民在显微镜下检查组织并分析实验室数据进行诊断，病理学 研究在很大程度上是描述性的。这种方法不再足够，我们必须准备 理解和应用高级技术以执行更精确和个性化的病理学家 诊断除了使用创新和改进的研究和诊断癌症的方法。这 威尔·康奈尔（Weill Cornell）病理学和实验室医学系已培训了许多杰出的病理学家 在许多亚科领域，但这只有使用创新的方法才能增加对 我们将能够培养有助于促进癌症病理领域的领导者的未来。非政府组织 计划采用整体和多学科的方法，其中考虑了癌症患者的各个方面 从肿瘤本身到体外和体内癌症模型，再到患者的血液和 微生物感染。那是解剖学和临床病理学的学员（即实验室医学） 包括，将是具有医学博士或医学博士/博士学位的个人，从事病理或研究金或研究金或 拥有博士学位的学员在实验室医学领域进行临床研究金，他们致力于学术 包括癌症研究在内的职业。我们的学员将通过在A中度过两年 研究实验室在以下一个或多个主要主题中工作：1）分子诊断和细胞 治疗，2）癌症病理学，3）高级成像和4）肿瘤微环境。基础 非政府组织计划的原则将是确保所有病理项目与癌症研究有关 患者样本以及癌症模型的比较病理。总体方法将 支持所有项目是：i）生物统计学和数据科学，ii）机器学习和人工智能，以及 iii）基因组学，表观基因组学，蛋白质组学和代谢组学。该计划的教师在专业中具有专业知识 主题和特定方法，这将允许教学基础技能以及高度 定制的教育计划。这将通过建立强制性非政府组织课程作为 以及有关数据科学和职业发展的其他课程要求，这将允许学员 与他们的心理委员会设计个性化课程的灵活性。我们还将利用迈耶 癌症中心和Weill Cornell临床和转化科学中心（CTSC）资源以教育 下一代从事癌症的病理学家。