Next-Gen Oncopathology Program

下一代肿瘤病理学(NGO)计划的总体使命是培训年轻的诊断师以满足 肿瘤发病机制及新的肿瘤干预措施的研究进展 从而将病理学领域引向未来。专门的病理学家已经参与其中 至少自19世纪以来，通过检查组织和其他标本来进行癌症诊断，并在 病理学已经逐渐被结构化和细分了。病理学培训计划传统上教会 居民在显微镜下检查组织并分析实验室数据进行诊断，并进行病理学检查 研究主要是描述性的。这种方法已经不够，我们必须做好准备。 让病理学家了解和应用先进技术，使手术更加精准和个性化 除了利用创新和改进的方法进行研究和诊断癌症外，还可以进行癌症诊断。这个 威尔·康奈尔大学病理与实验室医学系培养了无数优秀的病理学家 在许多次级专业领域，但只有在使用创新方法的情况下，才能 未来，我们将能够培养出推动癌症病理学领域发展的领导者。非政府组织 该计划采取了全面和多学科的方法，其中考虑了癌症患者的所有方面， 从肿瘤本身，到体外和体内的癌症模型，再到患者血液和 微生物感染。因此，解剖学和临床病理学(即实验室医学)的受训人员将 包括，将是拥有MD或MD/PhD学位的个人，正在进行病理学住院医师或研究员资格，或者 具有博士学位的实习生在实验室医学方面担任临床研究员，他们致力于学术 包括癌症研究在内的职业。我们的学员将通过两年的培训获得专业知识和深度 从事以下一个或多个主要主题的研究实验室：1)分子诊断和细胞学 治疗，2)肿瘤病理生物学，3)先进影像和4)肿瘤微环境。基础性的 非政府组织计划的原则是确保所有的病理学项目都与癌症研究有关 患者样本以及癌症模型的比较病理学。最重要的方法将 支持的所有项目是：i)生物统计学和数据科学，ii)机器学习和人工智能，以及 三)基因组学、表观基因组学、蛋白质组学和代谢组学。该项目的教职员工拥有该专业的专业知识。 主题和具体方法，这将允许教授基本技能以及高度 定制教育计划。这将通过设立一个强制性的非政府组织课程来实现，如 以及关于数据科学和职业发展的额外课程要求，这将允许学员 灵活地与他们的指导委员会一起设计个性化课程。我们还将利用Meyer 癌症中心和威尔康奈尔临床和翻译科学中心(CTSC)的资源，以教育 致力于癌症研究的下一代病理学家。

The Next-Gen Oncopathology (NGO) program has the overall mission of training young diagnosticians to meet advances in our understanding of the mechanisms of cancer pathogenesis and new oncological interventional approaches thereby leading the field of pathology into the future. Specialized pathologists have been involved in cancer diagnostics by examining tissues and other specimens since at least the 19th century, and training in pathology has been incrementally structured and subspecialized. Pathology training programs traditionally teach residents to examine tissue under the microscope and analyze laboratory data for diagnosis, with pathology research being largely descriptive. This approach is no longer sufficient, and it is essential that we prepare pathologists to understand and apply advanced technologies to perform more precise and personalized diagnostics in addition to utilizing innovative and improved ways to conduct research and diagnose cancer. The Weill Cornell Department of Pathology and Laboratory Medicine has trained numerous outstanding pathologists in many subspecialty areas, but it is only with the use of an innovative approach incorporating a view towards the future that we will be able to produce leaders that will advance the field of cancer pathology. The NGO program takes a holistic and multidisciplinary approach, where all aspects of a cancer patient are considered, ranging from the tumors themselves, to in vitro and in vivo cancer models, to changes in the patients’ blood and microbial infections. Thus, trainees in both Anatomic and Clinical Pathology (i.e. Laboratory Medicine) will be included, which will be individuals with MD or MD/PhD degrees doing a Pathology Residency or Fellowship, or trainees with PhD degrees doing a clinical fellowship in Laboratory Medicine, who are committed to an academic career that includes cancer research. Our trainees will gain expertise and depth by spending two years in a research laboratory working in one or more of the following major themes: 1) molecular diagnosis and cellular therapies, 2) cancer pathobiology, 3) advanced imaging and 4) tumor microenvironment. The foundational principles of the NGO program will be to ensure that all the pathology projects relate to the study of cancer patient samples as well as the comparative pathology of cancer models. Overarching methodologies that will support all of the projects are: i) biostatistics and data science, ii) machine learning and artificial intelligence, and iii) genomics, epigenomics, proteomics and metabolomics. Faculty in the program have expertise in the major themes and specific methodologies, which will allow for the teaching of foundational skills as well as a highly customized educational plan. This will be accomplished by the establishment of a mandatory NGO Course as well as additional course requirements on data science and career development, which will allow trainees flexibility to design a personalized curriculum with their mentoring committee. We will also leverage the Meyer Cancer Center and the Weill Cornell Clinical and Translational Science Center (CTSC) resources to educate the next generation of pathologists working on cancer.