Looking Back to Look Forward: Social Environment Across the Life Course, Epigenetics, and Birth Outcomes in Black Families

回顾过去并展望未来：生命历程中的社会环境、表观遗传学和黑人家庭的出生结果

• 批准号: 10676220
• 负责人: Jaime Catherine Slaughter-Acey
• 金额: $ 59.91万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676220
• 关键词: Address; Affect; Aging; American; Archives; Back; Behavioral; Biological Aging; Biological Assay; Biological Markers; Birth; Birth Weight; Black Populations; Black race; Blood; Child; Cross-Sectional Studies; DNA Methylation; Data; Enrollment; Environment; Environmental Risk Factor; Epigenetic Process; Family; Fetal Growth; Generations; Genomics; Health; Healthcare; Individual; Length; Life Cycle Stages; Link; Measures; Mediating; Methylation; Modeling; Mothers; Neighborhoods; Newborn Infant; Outcome; Pathway interactions; Perinatal; Population; Pregnancy; Pregnant Women; Premature Birth; Race; Research; Research Personnel; Risk; Role; Sampling; Site; Social Environment; Socioeconomic Status; Source; Spottings; Stress; Stress and Coping; Theoretical model; Time; United States; Validation; Variant; Woman; Work; black women; black/white disparity; cohort; critical period; epigenome; epigenomics; health determinants; improved; indexing; infant outcome; insight; maternal stress; minority health; novel strategies; offspring; perinatal health; perinatal outcomes; prenatal; racial disparity; racism; social; social factors; sound; stressor; success; telomere

Improving the health outcomes for infants and children has been a national priority in the United States (US) for over a century. Despite great strides in improving perinatal health care and utilization among American women, key perinatal indicators have remained stagnant or worsened, the US continues to rank near the bottom, and racial disparities are persistent. While studies now have gone beyond behavioral and biomedical determinants of health and encompass the social environment, most research still remains focused on the time shortly before or during the pregnancy Improvements in perinatal health will require utilization of frameworks which integrate life-course and multiple-determinant models of health. Though the body of evidence linking the prenatal social environment, particularly maternal stress, and epigenome is growing, little work has yet explored the life course antecedents to the prenatal social environment and the impact on epigenetic methylation or telomere length. Based on our widely embraced framework for perinatal health that marries a multiple determinants model with a life course approach, we will investigate maternal social environmental influences on maternal methylation and telomere length. Change as well as critical periods will be assessed as the maternal social environment over the maternal life course may independently, cumulatively, and interactively impact the maternal epigenomic profile and its changes over the life course. Archived newborn blood spots, available for all pregnant women in this unique cohort of Black births in metro Detroit, will be assayed to determine the presence of epigenetic methylation and telomere length of mothers at their own birth; maternal measures at the index pregnancy will be derived from analogous blood spots collected in our study. Neighborhood level data will utilize both administrative and subjective measures of neighborhood. In addition to determining associations between the maternal social environment and her epigenomic features across her life course, we will endeavor to explore potential pathways linking the social environment and epigenome across the maternal life course with the perinatal outcomes of her offspring. Researchers have recently begun to consider social environmental factors and how they relate to epigenomic features as well as adverse perinatal outcomes. Yet those populations disproportionately affected by these outcomes are grossly underrepresented in genomic studies. Our sample of 1,000 births to Black women, with nearly half expected to women residing in Detroit, will provide a rich source of data on the maternal social environment across the life course and the epigenome. Our team possesses tremendous expertise in the study of perinatal outcomes as well as measures of social environmental factors often overlooked or not modeled in such a way as to provide understanding of mechanisms. Our study will substantially increase evidence about the importance of the maternal social context at multiple points in the life course on her epigenome and birth outcomes in offspring. The work holds promise for significantly increasing understanding about how social factors have influence across generations through epigenetic processes.

改善婴儿和儿童的健康状况一直是美国的国家优先事项 (US)已经有世纪了尽管美国人在改善围产期保健和利用方面取得了很大进展， 妇女，关键围产期指标仍然停滞不前或恶化，美国继续排名接近底部， 种族差异依然存在。虽然现在的研究已经超越了行为和生物医学 健康的决定因素，包括社会环境，大多数研究仍然集中在时间 在怀孕前不久或怀孕期间，围产期健康的改善将需要利用框架 它整合了生命过程和多种健康决定因素模型。 尽管大量证据表明产前社会环境，特别是母亲的压力， 尽管表观基因组正在增长，但很少有工作探索产前社会环境的生命历程前因 以及对表观遗传甲基化或端粒长度的影响。基于我们广泛接受的框架， 围产期健康，结婚的多个决定因素模型与生命过程的方法，我们将调查 母体社会环境对母体甲基化和端粒长度的影响。变化以及 关键时期将被评估为母亲的社会环境，在母亲的生命过程中， 独立地、累积地和交互地影响母体表观基因组谱及其在 生命历程存档的新生儿血点，可供所有孕妇在这个独特的黑人出生队列 在底特律大都会，将进行测定，以确定表观遗传甲基化和端粒长度的存在， 母亲在自己的出生;母亲在指数怀孕的措施将来自类似的血斑 收集在我们的研究中。邻里层面的数据将利用行政和主观措施， 小区除了确定母亲的社会环境和她的行为之间的联系之外， 在她的生活过程中，我们将奋进探索潜在的途径，连接社会 环境和表观基因组在母亲的生命过程中与她的后代的围产期结果。 研究人员最近开始考虑社会环境因素，以及它们如何与 表观基因组特征以及不良围产期结局。然而，这些人口不成比例地受到影响， 这些结果在基因组研究中的代表性严重不足。我们的1,000个黑人新生儿样本 预计近一半的女性居住在底特律，将提供有关孕产妇死亡的丰富数据来源。 整个生命过程中的社会环境和表观基因。我们的团队拥有丰富的专业知识， 研究围产期结果以及社会环境因素的措施往往被忽视或没有建模 以提供对机制的理解。我们的研究将大大增加证据， 母亲的社会背景在她的表观基因组和出生的生命过程中的多个点的重要性 后代的结果。这项工作有望大大提高人们对社会因素如何影响人类健康的理解。 通过表观遗传过程影响几代人。