Admin-Core-001

管理核心-001

• 批准号: 10676292
• 负责人: Jane F Reckelhoff
• 金额: $ 51.36万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-08 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676292
• 关键词: Admin; Core; 001

ADMINISTRATIVE, MENTORING AND EDUCATION CORE A: SUMMARY The major goal of Phase 2 of COBRE funding of the Mississippi Center of Excellence in Perinatal Research (MS CEPR) is to further the sustainability of an innovative, nationally recognized center of excellence in perinatal research spanning the spectrum from adverse pregnancy to subsequent health outcomes in mothers and offspring. More specifically, perinatal research encompasses the study of disease states that occur during gestation and early post-natal development that result in long-term adverse consequences in the mother and offspring across their lifespans. Research focuses on the integrative relationships and health disparities in adverse pregnancy, pregnancy outcomes, and developmental programming of cardiovascular, renal, metabolic and behavioral diseases. This is an important area for research especially in light of the increasing evidence of long term health consequences brought about by adverse fetal environment, and subsequent low birth weight. An adverse perinatal environment is thought to account at least in part for the development of obesity, cardiovascular, renal, and behavioral diseases later in life for male and female offspring, and predispose the mothers for increased risk of these diseases with aging. This is especially important for Mississippi since we have one of the highest rates of preeclampsia, low birth weight, preterm labor, obesity, cardiovascular, renal and metabolic diseases and hypertension in the United States. The addition of COVID19 and the complications associated with it further add to disproportionate levels of morbidity and mortality in both our Caucasian and African American populations. Thus, Phase 2 of this COBRE will continue to improve sustainability and research excellence in the MS CEPR by providing infrastructure and capacity for continued building of a multidisciplinary, diverse group of basic, clinical and population scientists working on the common synergistic theme of perinatal diseases and health disparities and to facilitate their collaborations. Specific Aims of the Administrative, Mentoring and Education Core A are to provide leadership for all aspects of the MS CEPR; coordinate and provide support for all Center-related activities; maintain and improve mentoring and education programs for MS CEPR research project leaders (RPLs) or pilot project leaders (PPLs); interface with the NIGMS, the University of Mississippi Medical Center (UMMC) administration, the UMMC Office of Research and Sponsored Programs including Pre- and Post-Award Centers, the departments represented by RPLs and PPLs; recruit, train, and mentor a diverse group of graduate students and postdoctoral fellows to provide the next generation of perinatal researchers and to provide mentoring experience for RPLs and PPLs as needed; organize networking meetings and seminars as well as meetings of the Executive Committee, Internal and External Advisory Committees; and increase the number of investigators at UMMC who focus on perinatal research by working with department chairs to hire new perinatal investigators.

核心A：摘要 COBRE资助密西西比围产期研究卓越中心第2阶段的主要目标 (MS CEPR）是为了进一步促进创新的，国家认可的卓越中心的可持续性， 围产期研究，范围从不良妊娠到母亲随后的健康结果 和后代。更具体地说，围产期研究包括对围产期期间发生的疾病状态的研究。 妊娠和产后早期发育，对母亲造成长期不良后果， 在他们的一生中繁衍后代。研究的重点是综合关系和健康差距， 不良妊娠，妊娠结局，以及心血管，肾脏， 代谢和行为疾病。这是一个重要的研究领域，特别是鉴于越来越多的 不利的胎儿环境带来的长期健康后果的证据，以及随后的低 出生体重不良的围产期环境被认为至少部分地导致了 肥胖，心血管，肾脏和行为疾病，在以后的生活中的男性和女性后代，和 随着年龄的增长，母亲患这些疾病的风险会增加。这对于以下方面尤为重要： 密西西比，因为我们是先兆子痫，低出生体重，早产，肥胖， 心血管、肾脏和代谢疾病以及高血压。COVID的加入19以及与之相关的并发症进一步增加了不成比例的发病率和死亡率， 我们的白人和非裔美国人。因此，COBRE的第2阶段将继续改进 通过提供持续的基础设施和能力， 建立一个由基础、临床和人口科学家组成的多学科、多样化小组， 在这方面，教科文组织将继续努力，加强围产期疾病和健康差距的协同主题，并促进它们的合作。具体 行政、指导和教育核心A的目标是为MS的各个方面提供领导 CEPR;协调和支持所有与中心相关的活动;保持和改善指导， MS CEPR研究项目负责人（RPLs）或试点项目负责人（PPLs）的教育计划;接口 与NIGMS，密西西比大学医学中心（UMMC）管理，UMMC办公室， 研究和赞助计划，包括前和后奖中心，部门代表， RPL和PPL;招募，培训和指导一群不同的研究生和博士后研究员， 提供下一代围产期研究人员，并为RPL和PPL提供指导经验 组织网络会议和研讨会以及执行委员会会议， 内部和外部咨询委员会;增加UMMC的调查员人数， 围产期研究，与系主任合作，雇用新的围产期调查员。