Mississippi Center of Excellence in Perinatal Research, Phase 2

密西西比围产期研究卓越中心 总结 该提案将继续在第二阶段提供资金，以推动和维持密西西比中心的发展。 卓越的围产期研究（MS CEPR）COBRE在密西西比大学医学中心 （UMMC）。围产期研究包括研究疾病状态，其病因是在围产期， 妊娠和产后早期发育，对母亲和后代造成长期影响 在他们的一生中。第1阶段的研究重点是整合关系和健康差异 不良妊娠、妊娠结局和人类疾病的发育规划， 12名研究者（2名临床医生，8名女性和5名代表性不足的少数民族）进行的动物研究， 联邦资金超过460万美元（总额超过1 200万美元），并提供了115份出版物。该中心从 5个基础科学部门和3个临床部门的17名研究者对51名研究者。开发和支持MS CEPR核心还使另外160名当地和校外调查员获得了75笔PHS/非PHS赠款。 我们的长期目标是发展一个国际公认的MS CEPR，致力于改善生活， 妇女及其后代，特别是在密西西比，通过发现，创新和翻译，以防止 减少围产期疾病造成的死亡和残疾。COBRE第二阶段的主要目标是 进一步推进MS CEPR，为多学科，多样化的团队提供基础设施和能力， 研究围产期疾病共同协同主题的基础、临床和人口科学家， 健康差距，并促进他们的合作。继续支持MS CEPR将提供 多样化的研究项目和试点项目研究人员与优秀的导师和必要的 研究核心服务，以加快获得校外资金，并提供职业发展 将初级调查员培养成高效、独立的调查员， 研究人员正在改变研究方向，就以下共同主题进行协同研究： 围产期研究和疾病的发展规划，这对我们的人口非常重要， 密西西比。该中心的目标是通过提供一个刺激的辅导环境， 加强研究能力，增加研究人员和研究人群的多样性， 并加强UMMC的研究基础设施。

MISSISSIPPI CENTER OF EXCELLENCE IN PERINATAL RESEARCH SUMMARY This proposal is to continue funding in Phase 2 to advance and sustain the Mississippi Center of Excellence in Perinatal Research (MS CEPR) COBRE at the University of Mississippi Medical Center (UMMC). Perinatal research encompasses the study of disease states that have their etiology during gestation and early post-natal development that result in long term consequences in the mother and offspring across their lifespans. Studies during Phase 1 focused on the integrative relationships and health disparities among adverse pregnancy, pregnancy outcomes and developmental programming of diseases in human and animal studies by 12 investigators (2 clinicians, 8 women, and 5 under-represented minorities), who secured > $4.6 million in federal funding (>$12 million total) and contributed 115 publications. The Center grew from 17 investigators to 51 in 5 basic science and 3 clinical departments. Development and support for the MS CEPR cores also allowed 160 additional local and extramural investigators to obtain 75 PHS/non-PHS grants. Our longterm goal is to develop an internationally recognized MS CEPR dedicated to improving the lives of women and their offspring, especially in Mississippi, through discovery, innovation, and translation to prevent and reduce death and disability from perinatally-induced diseases. The major goal of Phase 2 of this COBRE is to further advance the MS CEPR to provide infrastructure and capacity for a multidisciplinary, diverse group of basic, clinical and population scientists working on the common synergistic theme of perinatal diseases and health disparities and to facilitate their collaborations. Continuing to support the MS CEPR will provide a diverse group of Research Project and Pilot Project investigators with outstanding mentors and the necessary research core services to accelerate acquisition of extramural funding and provide career development programs to develop the junior investigators into highly productive, independent investigators, and the senior investigators who are changing research direction to conduct synergistic research on the common theme of perinatal research and developmental programming of disease that is so important for our population in Mississippi. The goals of the Center are achieved by providing a stimulating mentoring environment, strengthening research capacity and capabilities, increasing diversity of our researchers and study populations, and enhancing the research infrastructure at UMMC.