Mississippi Center of Excellence in Perinatal Research, Phase 2

密西西比州围产期研究卓越中心 摘要 这项提议是在第二阶段继续提供资金，以推进和维持密西西比中心 密西西比大学医学中心围产期卓越研究(MS CEPR)科布雷 (UMMC)。围产期研究包括对疾病状态的研究，这些疾病的病因在 妊娠和出生后早期发育对母亲和后代造成长期后果 在他们的一生中。第一阶段的研究集中在综合关系和健康差异上 在不良妊娠、妊娠结局和疾病的发展规划之间 12名研究人员(2名临床医生、8名女性和5名代表性不足的少数民族)进行的动物研究，他们确保了 &gt；获得了460万美元的联邦资金(总计1200万美元)，并贡献了115种出版物。该中心是从 5个基础科学科室和3个临床科室共51名研究人员。MS的开发和支持 经济、社会和文化权利委员会的核心还允许另外160名当地和校外调查员获得75份PHS/Non-PHS补助金。 我们的长期目标是发展一个国际公认的MS CEPR，致力于改善 妇女及其后代，特别是在密西西比州，通过发现、创新和翻译来防止 并减少围产期引发的疾病造成的死亡和残疾。Cobre第二阶段的主要目标是 进一步推进MS CEPR，为多学科、多样化的 基础、临床和人口科学家致力于围产期疾病和 卫生方面的差距，并促进他们的合作。继续支持微软CEPR将提供 不同的研究项目和试点项目调查员小组，具有杰出的导师和必要的 研究核心服务，以加速获得外部资金并提供职业发展 将初级调查员培养成高效、独立的调查员和高级调查员的计划 研究人员正在改变研究方向，就以下共同主题进行协同研究 疾病的围产期研究和发展规划，这对我们的人口在 密西西比州。中心的目标是通过提供一个激励的指导环境来实现的， 加强研究能力和能力，增加我们研究人员和研究人群的多样性， 以及加强UMMC的研究基础设施。

MISSISSIPPI CENTER OF EXCELLENCE IN PERINATAL RESEARCH SUMMARY This proposal is to continue funding in Phase 2 to advance and sustain the Mississippi Center of Excellence in Perinatal Research (MS CEPR) COBRE at the University of Mississippi Medical Center (UMMC). Perinatal research encompasses the study of disease states that have their etiology during gestation and early post-natal development that result in long term consequences in the mother and offspring across their lifespans. Studies during Phase 1 focused on the integrative relationships and health disparities among adverse pregnancy, pregnancy outcomes and developmental programming of diseases in human and animal studies by 12 investigators (2 clinicians, 8 women, and 5 under-represented minorities), who secured > $4.6 million in federal funding (>$12 million total) and contributed 115 publications. The Center grew from 17 investigators to 51 in 5 basic science and 3 clinical departments. Development and support for the MS CEPR cores also allowed 160 additional local and extramural investigators to obtain 75 PHS/non-PHS grants. Our longterm goal is to develop an internationally recognized MS CEPR dedicated to improving the lives of women and their offspring, especially in Mississippi, through discovery, innovation, and translation to prevent and reduce death and disability from perinatally-induced diseases. The major goal of Phase 2 of this COBRE is to further advance the MS CEPR to provide infrastructure and capacity for a multidisciplinary, diverse group of basic, clinical and population scientists working on the common synergistic theme of perinatal diseases and health disparities and to facilitate their collaborations. Continuing to support the MS CEPR will provide a diverse group of Research Project and Pilot Project investigators with outstanding mentors and the necessary research core services to accelerate acquisition of extramural funding and provide career development programs to develop the junior investigators into highly productive, independent investigators, and the senior investigators who are changing research direction to conduct synergistic research on the common theme of perinatal research and developmental programming of disease that is so important for our population in Mississippi. The goals of the Center are achieved by providing a stimulating mentoring environment, strengthening research capacity and capabilities, increasing diversity of our researchers and study populations, and enhancing the research infrastructure at UMMC.