Mississippi Center of Excellence in Perinatal Research

密西西比围产期研究卓越中心

• 批准号: 10189638
• 负责人: Jane F Reckelhoff
• 金额: $ 232.5万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-08 至 2022-08-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10189638
• 关键词: Advisory Committees; African American; Aging; Area; Basic Science; Behavioral; Biochemistry; Biomedical Research; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caucasians; Center for Translational Science Activities; Cessation of life; Child; Clinical; Clinical Research; Clinical Sciences; Collaborations; Complex; Core Facility; Data; Development; Discipline; Disease; Education; Effectiveness; Endocrinology; Ensure; Environment; Evaluation; Extramural Activities; Faculty; Fostering; Funding; Genetic; Genomics; Goals; Grant; Health; Hypertension; Incidence; Infrastructure; International; Kidney; Kidney Diseases; Life; Light; Longevity; Low Birth Weight Infant; Medical center; Mentors; Metabolic; Metabolic Diseases; Mississippi; Molecular Biology; Monitor; Morbidity - disease rate; Mothers; National Institute of General Medical Sciences; Nephrology; Neurosciences; Obesity; Outcome; Pathology; Pediatric epidemiology; Perinatal; Pharmacology; Physiology; Policies; Population; Population Research; Population Sciences; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prevalence; Process; Proteomics; Psychiatry; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Research Support; Scientist; Seasons; Services; Training; Translations; Underrepresented Minority; United States; United States National Institutes of Health; Universities; Woman; developmental disease; disability; disease disparity; disorder risk; experience; fetal; health disparity; improved; infrastructure development; innovation; insight; interest; leadership development; meetings; minority investigator; mortality; multidisciplinary; next generation; novel; obesity development; offspring; postnatal development; prevent; programs; recruit; study population; undergraduate student

MISSISSIPPI CENTER OF EXCELLENCE IN PERINATAL RESEARCH ADMINISTRATIVE, MENTORING AND EDUCATION CORE A SUMMARY The major goal of the Mississippi Center of Excellence in Perinatal Research (CEPR) is to develop an innovative, independent and sustainable center of excellence in perinatal research and treatment spanning the spectrum from adverse pregnancy to subsequent outcomes in offspring. More specifically, perinatal research encompasses the study of disease states that may occur during gestation and early post-natal development that result in long term consequences in the mother and offspring across their lifespan. Studies will focus on the integrative relationships and health disparities in adverse pregnancy, pregnancy outcomes and developmental programming of cardiovascular, renal, metabolic and behavioral diseases. This is an important area for research especially in light of the increasing evidence of long term health consequences brought about by adverse fetal environment and subsequent low birth weight during pregnancy both for the mother and offspring. An adverse perinatal environment is thought to account at least in part for the development of obesity, cardiovascular, renal, and behavioral diseases later in life for the offspring, and predispose the mothers for increased risk of these diseases with aging. Mississippi has one of the highest rates of preeclampsia, obesity, cardiovascular, renal and metabolic diseases and hypertension in the United States, leading to disproportionate levels of morbidity and mortality in our population. The incidence of preeclampsia is 10% in Mississippi, compared to 5% in the US. The prevalence of children with low birth weight in Mississippi is 12% in Caucasian children and 18% in African American children, compared to 5-8% in the other states. Studies that will provide novel insight into mechanisms responsible for the high rates of these diseases in Mississippi will require a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major goal of this proposal is to develop a research Center that will provide infrastructure and capacity for a multidisciplinary, diverse group of basic, clinical and population scientists working on the common synergistic theme of perinatal diseases and health disparities and to facilitate their collaborations. The specific aims of the Administrative, Mentoring and Education Core A include the following: 1. To provide overall leadership for development of infrastructure, mentoring programs and research core facilities that foster excellence in perinatal research spanning the spectrum from adverse pregnancy to subsequent outcomes in offspring and will lead to development of an innovative, internationally recognized Center of Excellence. 2. To develop, implement and monitor a Mentoring and Education Program that facilitates development of junior faculty investigators into independent, extramurally (NIH) funded researchers. 3. To develop and implement a Pipeline Grants Program for promising new investigators, with emphasis on recruiting and mentoring under-represented minority investigators. 4. To develop and implement educational programs that will facilitate collaborations and interactions among investigators from multiple disciplines in perinatal research at UMMC. 5. To develop and implement programs for recruiting, training, and mentoring a diverse group of undergraduate students and postdoctoral trainees to provide experience in mentoring for the junior investigators and so that the trainees become the next generation of perinatal researchers. 6. To implement formative and summative evaluation strategies for overall progress and effectiveness of the CEPR junior investigators, programs, and cores. 7. To provide high-level program administrative support and fiscal oversight of all research projects and cores. 8. To organize networking meetings and seminars related to the Center as well as meetings of the Executive Committee, Internal and External Advisory Committees. 9.To ensure that all Center programs, initiatives, policies and reporting mechanisms to UMMC and NIGMS are optimally developed, implemented, and administered within federal granting agency policies and deadlines.

密西西比围产期研究卓越中心 行政、辅导和教育核心A 总结 密西西比围产期研究卓越中心（CEPR）的主要目标是开发一种 创新，独立和可持续的卓越中心，在围产期研究和治疗，跨越 从不良妊娠到后代的后续结果。更具体地说，围产期研究 包括对妊娠期和产后早期发育期间可能发生的疾病状态的研究 这会对母亲和后代的一生产生长期影响。研究将集中在 不良妊娠、妊娠结局和妊娠结局之间的综合关系和健康差异， 心血管、肾脏、代谢和行为疾病的发展规划。这是一 这是一个重要的研究领域，特别是鉴于越来越多的证据表明长期健康后果 不利的胎儿环境和随后的低出生体重在怀孕期间， 母亲和孩子一个不利的围产期环境被认为是至少部分原因， 后代日后出现肥胖、心血管、肾脏和行为疾病，以及 随着年龄的增长，母亲患这些疾病的风险会增加。密西西比有着世界上 在美国，先兆子痫、肥胖、心血管、肾脏和代谢疾病以及高血压的发病率 这导致我国人口中发病率和死亡率过高。的发生率 先兆子痫在密西西比是10%，而在美国是5%。低出生率儿童的普遍性 在密西西比，白人儿童的体重为12%，非裔美国儿童为18%，而白人儿童的体重为5-8%。 在其他州。研究将提供新的洞察机制负责高利率的 密西西比的这些疾病将需要一个包括多学科的研究范式的转变 综合方法，结合基础、临床和人口科学家的努力。一个主要目标是 建议是发展一个研究中心，将提供基础设施和能力， 基础、临床和人口科学家组成的不同小组，致力于围产期保健的共同协同主题， 疾病和健康差距，并促进他们的合作。 行政、指导和教育核心A的具体目标包括： 1.为基础设施、指导计划和研究核心的发展提供全面领导 设施，促进卓越的围产期研究，涵盖范围从不良妊娠， 随后的结果在后代，并将导致发展创新，国际公认的 卓越中心。 2.制定、实施和监督指导和教育计划，以促进 初级教师调查员对独立的、壁外（NIH）资助的研究人员进行调查。 3.为有前途的新研究者制定和实施管道赠款计划，重点是 招募和指导代表性不足的少数族裔调查员。 4.制定和实施教育计划，促进合作和互动， 来自UMMC围产期研究多个学科的研究人员。 5.制定和实施招聘，培训和指导多元化本科生群体的计划 学生和博士后学员提供经验，指导初级研究人员， 受训人员将成为下一代围产期研究人员。 6.实施形成性和总结性评价战略，以促进 CEPR初级调查员，程序和核心。 7.为所有研究项目和核心提供高水平的计划行政支持和财政监督。 8.组织与中心有关的网络会议和研讨会以及执行会议 委员会，内部和外部咨询委员会。 9.确保中心的所有计划、倡议、政策和向UMMC和NIGMS报告的机制， 在联邦授权机构的政策和最后期限内进行最佳开发、实施和管理。