权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Iron and Heme Core

铁和血红素核心

基本信息

批准号：
10676101
负责人：
Laurie K Jackson
金额：
$ 17.8万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-05 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676101
关键词：
Aminolevulinic Acid Awareness Bilirubin Biliverdine Biological Biological Assay Cells Charge Communities Copper Country Disease Education Enzymes Experimental Designs Feces Fee-for-Service Plans Health Services Accessibility Hematology Heme Human Hydroxymethylbilane Synthase Inductively Coupled Plasma Mass Spectrometry Institution Iron Isomerism Laboratories Liquid substance Manganese Measurement Measures Metals Methods National Institute of Diabetes and Digestive and Kidney Diseases Non-Malignant Organelles Pathway interactions Persons Porphobilinogen Synthase Porphyrins Progress Reports Protocols documentation Protoporphyrinogen oxidase Quality Control Research Research Personnel Resources Sampling Services System Time Tissues Training Universities Urine Uroporphyrinogen Decarboxylase Uroporphyrins Utah Validation Whole Blood Zinc coproporphyrinogen oxidase enzyme activity ferrochelatase heme C heme a heme biosynthesis learning strategy member novel protoporphyrin IX tissue/cell culture web site zinc-protoporphyrin-9

项目摘要

PROJECT SUMMARY The Iron and Heme Core, created through the NIDDK sponsored Center for Iron and Heme Disorders (CIHD), provides analysis of metals (primarily iron), porphyrins, porphyrin precursors and heme. The core also measures activity of the enzymes in the heme biosynthesis pathway. Analysis and absolute quantitation of these pathway intermediates or enzyme activities in cells, tissue, whole blood, urine and feces is available to laboratories nationally. This core is central for many labs that measure these enzyme activities, compounds & metals in a diverse range of experimental systems. The need for this core is borne out by the fact that it has served more than 34 different laboratories from 20 research institutions in the past four years via its recharge system. This core has assayed more than 4000 samples during this time. CIHD investigators are provided priority access to these services. Core staff members are also available to host training sessions to assist researchers at all levels in experimental design to leverage the most from Core established methods. We share our protocols on the CIHD website providing consistency, validation and quality control within our field of research. The unique services the Iron and Heme Core offers has become a national resource.

项目总结铁和血红素核心，由NIDDK赞助的铁和血红素疾病中心(CIHD)创建，提供对金属(主要是铁)、卟啉、卟啉前体和血红素的分析。核心还包括测量血红素生物合成途径中的酶的活性。的分析和绝对量化这些途径的中间产物或酶在细胞、组织、全血、尿液和粪便中的活性可用于全国实验室。这一核心是许多实验室测量这些酶活性、化合物和金属在不同的实验系统中。对这个核心的需求从以下事实得到了证明：它已经在过去的四年里，它通过充值为来自20个研究机构的34个不同的实验室提供了服务系统。在此期间，该岩芯已经检测了4000多个样品。提供了CIHD调查人员优先使用这些服务。核心工作人员也可以主持培训课程，以帮助各级研究人员在实验设计中最大限度地利用Core既定的方法。我们在CIHD网站上共享我们的协议，在我们的领域内提供一致性、验证和质量控制研究。铁和血红素核心提供的独特服务已成为国家资源。