Cell Procurement & Processing
电池采购
基本信息
- 批准号:10675715
- 负责人:
- 金额:$ 22.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AwardAwarenessBioinformaticsBiologyCellsCharacteristicsClinicalCollaborationsCommunitiesDataData Management ResourcesDiseaseDocumentationEducational workshopEnsureEquipment and supply inventoriesExplosionFeedbackFundingFunding MechanismsHematologyHematopoiesisHematopoieticHematopoietic stem cellsIndividualInfrastructureInstitutionInvestigationMeasuresModelingNatureNon-MalignantPriceProductionQuality ControlRecording of previous eventsReproducibilityResearchResearch PersonnelResourcesRetrievalSpecimenStandardizationSurveysTechniquesTechnologyTestingTimeTransplantationWorkbasecostexperiencefollow-uphigh standardimprovedinnovationmeetingsmembermultidimensional datanew technologynovelnovel strategiespostersprecursor cellprogramsquality assurancesatisfactionsearchable databaseskill acquisitionsoftware developmentsoftware systemsstem cellssuccesstext searchingtooluser-friendlyvirtualweb site
项目摘要
PROJECT SUMMARY/ABSTRACT - Cell Procurement and Processing Core
The purpose and objective of the Cell Procurement and Processing (Cell P&P) Core remains to advance the
understanding of hematopoiesis and nonmalignant disorders through the distribution of high-quality
hematopoietic products to the hematology research community. To meet this need, the early precursors of
Cell P&P Core was first established in 1999 under the original CCEH P30. Over the almost 20-year history,
The Cell P&P Core has become recognized as a national resource for normal hematopoietic cell products, as
evidenced by the 171 investigators at 69 institutions who have received hematopoietic products during the
previous award period. Moreover, utilization of resources from the Core have continued to grow and facilitate
investigations that have advanced our understanding of the biology governing normal hematopoiesis and
nonmalignant disorders. As part of the proposed award, the Cell P&P Core will leverage its expertise,
infrastructure, and experiences to increase production and utilization of the high-quality products to advance the
field of hematology research, while maintaining the current high standards for product quality as detailed in the
Research Strategy. Therefore, the Cell P&P Core proposes the following:
Specific Aim 1. Expand the number of users for enriched hematopoietic cell products of the highest
quality and uniformity to facilitate hematology research. We propose three new approaches to increase
user numbers. 1) The Cell P&P Core develop a novel User Satisfaction and Needs Program to provide
feedback and identify new users. 2) The Core will develop Virtual Workshops targeting existing and new
users. 3) The Core will develop a novel funding mechanism called Cell P&P New Investigator Award that
provide resources at significantly reduced prices. Specific Aim 2. Develop user-friendly, integrative and
comprehensive Data Management System (DMS) for hematopoietic specimens. The proposed DMS will
incorporate real-time assessment for tracking and retrieval of donor characteristic, pre-analytic variables,
SOPs, inventory, quality controls, quality assurances, and specimen distribution, which will have two major
beneficial effects. 1) The Core will be able to more efficiently provide users with the essential variables related
to their research. 2) The Core will be able to more rapidly and comprehensively assess quality measures and
evaluate potential variables impacting product uniformity. Specific Aim 3. Develop new and innovative
user-directed products to facilitate hematology research. Given the explosion of new technologies to
examine hematopoietic cells, it remains a challenge for investigators to acquire the skills to take advantage of
these technologies. By combining the expertise of Cell P&P and Tool Cores, we will be able to efficiently
develop and deliver user-directed products to those investigators who may not otherwise be able to develop
these products within their labs. Through these deliverables, we will broaden the research potential for these
investigators and provide a mechanism to increase hematology research.
项目摘要/摘要 - 电池采购和处理核心
细胞采购和加工 (Cell P&P) 核心的目的和目标仍然是推进
通过高质量的分布了解造血和非恶性疾病
为血液学研究界提供造血产品。为了满足这一需求,早期的先驱
Cell P&P Core 最初成立于 1999 年,当时的名称是 CCEH P30。在近20年的历史中,
Cell P&P Core 已被公认为正常造血细胞产品的国家资源,因为
69个机构的171名研究人员在研究期间接受过造血产品证明了这一点
上一奖励期。此外,核心资源的利用率持续增长并促进
这些研究增进了我们对控制正常造血的生物学的理解
非恶性疾病。作为拟议奖项的一部分,Cell P&P Core 将利用其专业知识,
基础设施和增加高质量产品生产和利用的经验,以推动
血液学研究领域,同时保持当前产品质量的高标准,详见
研究策略。因此,Cell P&P Core 提出以下建议:
具体目标1.扩大最高浓缩造血细胞产品的用户数量
质量和均匀性,以促进血液学研究。我们提出了三种新方法来提高
用户数量。 1) Cell P&P 核心开发了一项新颖的用户满意度和需求计划,以提供
反馈并识别新用户。 2) 核心将开发针对现有和新的虚拟研讨会
用户。 3) Core 将开发一种名为 Cell P&P 新研究者奖的新型资助机制
以大幅降低的价格提供资源。具体目标 2. 开发用户友好型、综合性和
用于造血样本的综合数据管理系统(DMS)。拟议的 DMS 将
纳入实时评估以跟踪和检索供体特征、预分析变量、
SOP、库存、质量控制、质量保证和样本分发,其中有两个主要内容
有益的影响。 1)Core将能够更高效地为用户提供相关的必要变量
他们的研究。 2) 核心将能够更快速、更全面地评估质量措施和
评估影响产品均匀性的潜在变量。具体目标 3. 开发新产品和创新产品
用户导向的产品促进血液学研究。鉴于新技术的爆炸式增长
检查造血细胞,对于研究人员来说,掌握利用造血细胞的技能仍然是一个挑战
这些技术。通过结合 Cell P&P 和 Tool Cores 的专业知识,我们将能够高效地
开发并向那些可能无法开发用户导向的产品的研究人员提供
这些产品在他们的实验室内。通过这些成果,我们将扩大这些领域的研究潜力
研究人员并提供一种增加血液学研究的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DEREK L STIREWALT其他文献
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{{ truncateString('DEREK L STIREWALT', 18)}}的其他基金
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对具有 NPM1^Pos/FLT3-IT^Neg 基因型的 AML 患者进行风险分层的新型生物标志物
- 批准号:
9899941 - 财政年份:2016
- 资助金额:
$ 22.96万 - 项目类别:
Novel Biomarkers to Risk-Stratify AML Patients with NPM1^Pos/FLT3-IT^Neg Genotype
对具有 NPM1^Pos/FLT3-IT^Neg 基因型的 AML 患者进行风险分层的新型生物标志物
- 批准号:
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- 资助金额:
$ 22.96万 - 项目类别:
Novel Biomarkers to Risk-Stratify AML Patients with NPM1^Pos/FLT3-IT^Neg Genotype
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- 批准号:
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9024460 - 财政年份:2012
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