Cell Procurement & Processing

电池采购

• 批准号: 10595863
• 负责人: DEREK L STIREWALT
• 金额: $ 7.55万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595863
• 关键词: Cell; Procurement; Processing

PROJECT SUMMARY/ABSTRACT - Cell Procurement and Processing Core The purpose and objective of the Cell Procurement and Processing (Cell P&P) Core remains to advance the understanding of hematopoiesis and nonmalignant disorders through the distribution of high-quality hematopoietic products to the hematology research community. To meet this need, the early precursors of Cell P&P Core was first established in 1999 under the original CCEH P30. Over the almost 20-year history, The Cell P&P Core has become recognized as a national resource for normal hematopoietic cell products, as evidenced by the 171 investigators at 69 institutions who have received hematopoietic products during the previous award period. Moreover, utilization of resources from the Core have continued to grow and facilitate investigations that have advanced our understanding of the biology governing normal hematopoiesis and nonmalignant disorders. As part of the proposed award, the Cell P&P Core will leverage its expertise, infrastructure, and experiences to increase production and utilization of the high-quality products to advance the field of hematology research, while maintaining the current high standards for product quality as detailed in the Research Strategy. Therefore, the Cell P&P Core proposes the following: Specific Aim 1. Expand the number of users for enriched hematopoietic cell products of the highest quality and uniformity to facilitate hematology research. We propose three new approaches to increase user numbers. 1) The Cell P&P Core develop a novel User Satisfaction and Needs Program to provide feedback and identify new users. 2) The Core will develop Virtual Workshops targeting existing and new users. 3) The Core will develop a novel funding mechanism called Cell P&P New Investigator Award that provide resources at significantly reduced prices. Specific Aim 2. Develop user-friendly, integrative and comprehensive Data Management System (DMS) for hematopoietic specimens. The proposed DMS will incorporate real-time assessment for tracking and retrieval of donor characteristic, pre-analytic variables, SOPs, inventory, quality controls, quality assurances, and specimen distribution, which will have two major beneficial effects. 1) The Core will be able to more efficiently provide users with the essential variables related to their research. 2) The Core will be able to more rapidly and comprehensively assess quality measures and evaluate potential variables impacting product uniformity. Specific Aim 3. Develop new and innovative user-directed products to facilitate hematology research. Given the explosion of new technologies to examine hematopoietic cells, it remains a challenge for investigators to acquire the skills to take advantage of these technologies. By combining the expertise of Cell P&P and Tool Cores, we will be able to efficiently develop and deliver user-directed products to those investigators who may not otherwise be able to develop these products within their labs. Through these deliverables, we will broaden the research potential for these investigators and provide a mechanism to increase hematology research.

项目汇总/摘要-单元采购和处理核心 单元采购和处理(单元P&P)核心的目的和目标仍然是促进 从优质品的分布看造血与非恶性疾病 向血液学研究界捐赠造血产品。为了满足这一需求，早期的先驱 CELL P&P Core于1999年在最初的CCEH P30下首次成立。在近20年的历史中， 细胞P&P核心已被公认为正常造血细胞产品的国家资源，如 来自69家机构的171名调查人员证明，这些机构在 之前的获奖期。此外，核心资源的利用继续增长和便利 研究促进了我们对控制正常造血和 非恶性疾病。作为拟议奖励的一部分，Cell P&P Core将利用其专业知识， 基础设施和经验，增加优质产品的生产和利用，促进 血液学研究领域，同时保持目前产品质量的高标准，如 研究策略。因此，Cell P&P Core提出了以下建议： 具体目标1.扩大用户数量最高的浓缩造血细胞产品 质量和一致性，以促进血液学研究。我们提出了三种新的方法来增加 用户编号。1)Cell P&P Core开发了一个新的用户满意和需求计划，以提供 反馈并确定新用户。2)核心将针对现有的和新的开发虚拟研讨会 用户。3)核心将开发一种新的资助机制，称为细胞P&P新研究员奖， 以显著降低的价格提供资源。具体目标2.开发用户友好、综合和 造血标本综合数据管理系统(DMS)。拟议的DMS将 包括实时评估，用于跟踪和检索捐赠者特征、分析前变量 标准操作规程、库存、质量控制、质量保证和样品分发，这将有两个主要方面 有益的影响。1)核心将能够更有效地向用户提供相关的基本变量 他们的研究。2)核心将能够更迅速和全面地评估质量措施和 评估影响产品一致性的潜在变量。具体目标三.开拓创新 以用户为导向的产品，促进血液学研究。鉴于新技术的爆炸性增长 检查造血细胞，对研究人员来说获得利用的技能仍然是一个挑战 这些技术。通过将Cell P&P和工具核心的专业知识相结合，我们将能够高效地 开发用户导向的产品并将其交付给那些原本可能无法开发的研究人员 这些产品都在他们的实验室里。通过这些成果，我们将拓宽这些领域的研究潜力。 并提供了一种增加血液学研究的机制。