Integrative Cardiovascular Pathophysiology

综合心血管病理生理学

• 批准号: 10676112
• 负责人: John William Elrod
• 金额: $ 35.16万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676112
• 关键词: Cardiovascular system; Functional disorder

Summary/Abstract This renewal application requests support for pre- and post-doctoral trainees in an Integrated Cardiovascular Pathophysiology (ICVP) training program. Faculty mentors in the ICVP training program primarily have their appointments within the Cardiovascular Research Center (Directed by Dr. Steven Houser, ICVP program director) or the Center for Translational Medicine (directed by Dr. Walter Koch, Co-Director of the ICVP program) at Temple University School of Medicine. The purpose of our program is to provide a broad based multidisciplinary training experience for pre-doctoral fellows, post-doctoral fellows and summer medical students in the area of integrative cardiovascular pathophysiology (ICVP). ICVP faculty members reside with many different basic science and clinical Departments, but their research laboratories are largely within the CVRC and CTM which are housed on two adjacent floors of a new medical research building. ICVP investigators/mentors have related interests in fundamental properties of the cardiovascular system and the aberrant changes in these properties that cause cardiovascular dysfunction in diseases including ischemic heart disease, hypertensive heart disease, atherosclerosis, ischemic vascular disease, metabolic syndrome and diabetic cardiovascular diseases. Graduate students and post-doctoral fellows will receive didactic training in human physiology and pathophysiology, complemented by advanced training in cellular and molecular biology and the appropriate use of animal models of human cardiovascular disease. Graduate student and fellow research projects will have basic and translational components. The students and fellows will be expected to investigate problems that go beyond a single molecule and address questions within the context of cardiovascular disease models. Portions of these projects will be performed in the laboratories of different investigators, ensuring that students and fellows are exposed to varied scientific approaches. All trainees will be involved in activities to enhance their grant and manuscript writing and oral communication skills. Group mentoring by junior and senior faculty will ensure trainees are well qualified to assume positions as leading investigators able to rapidly translate new knowledge into new therapies or targets for therapies. A variety of recruiting strategies will be used to attract a diverse group of trainees that reflect the diversity of our country. The goal is to train a diverse group of new Ph.Ds. and post-doctoral fellows that are able to fill a national need for the next generation of biomedical scientists who can develop therapies for cardiovascular diseases..

总结/摘要 此更新申请要求支持前和博士后学员在综合 心血管病理生理学（ICVP）培训计划。ICVP培训的教师导师 计划主要在心血管研究中心（直接 Steven Houser博士，ICVP项目主任）或转化医学中心（指导 由沃尔特·科赫博士，ICVP项目的联合主任）在坦普尔大学医学院。 我们计划的目的是提供一个基础广泛的多学科培训经验， 博士前研究员、博士后研究员和暑期医科学生， 综合心血管病理生理学（ICVP）。ICVP教师居住在许多 不同的基础科学和临床部门，但他们的研究实验室主要是 CVRC和CTM位于一个新的医学研究项目的两个相邻楼层， 建设ICVP研究者/导师对以下方面的基本性质有相关兴趣： 心血管系统和这些属性的异常变化，导致心血管疾病 包括缺血性心脏病，高血压性心脏病， 动脉粥样硬化、缺血性血管疾病、代谢综合征和糖尿病心血管疾病 疾病研究生和博士后研究员将接受教学培训， 生理学和病理生理学，辅之以细胞和分子的高级培训 生物学和人类心血管疾病动物模型的适当使用。研究生 学生和其他研究项目将有基本的和翻译的组成部分。学生 研究人员将被期望研究超越单个分子的问题， 解决心血管疾病模型背景下的问题。其中部分 项目将在不同研究人员的实验室进行，确保学生 和研究员接触到各种科学方法。所有学员都将参与活动 以提高他们的赠款和手稿的写作和口头沟通技巧。小组辅导 由初级和高级教师将确保学员有资格担任领导职务， 研究人员能够迅速将新知识转化为新的疗法或疗法目标。 将采用各种招聘策略来吸引多样化的学员， 我们国家的多样性。目标是培养一批多样化的新博士。和博士后 研究员能够满足国家对下一代生物医学科学家的需求， 可以开发心血管疾病的治疗方法。

项目成果

Sorafenib cardiotoxicity increases mortality after myocardial infarction.

• DOI: 10.1161/circresaha.114.303200
• 发表时间: 2014-05-23
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Duran JM;Makarewich CA;Trappanese D;Gross P;Husain S;Dunn J;Lal H;Sharp TE;Starosta T;Vagnozzi RJ;Berretta RM;Barbe M;Yu D;Gao E;Kubo H;Force T;Houser SR
• 通讯作者: Houser SR

Comparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heart.

• DOI: 10.1111/j.1752-8062.2010.00190.x
• 发表时间: 2010-06
• 期刊: Clinical and translational science
• 作者: Zincarelli C;Soltys S;Rengo G;Koch WJ;Rabinowitz JE
• 通讯作者: Rabinowitz JE

Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy.

• DOI: 10.1007/s00395-014-0456-3
• 发表时间: 2015-01
• 期刊: Basic research in cardiology
• 影响因子: 9.5
• 作者: Trappanese DM;Liu Y;McCormick RC;Cannavo A;Nanayakkara G;Baskharoun MM;Jarrett H;Woitek FJ;Tillson DM;Dillon AR;Recchia FA;Balligand JL;Houser SR;Koch WJ;Dell'Italia LJ;Tsai EJ
• 通讯作者: Tsai EJ

Brief mechanical ventilation impacts airway cartilage properties in neonatal lambs.

• DOI: 10.1002/ppul.21616
• 发表时间: 2012-08
• 期刊: PEDIATRIC PULMONOLOGY
• 影响因子: 3.1
• 作者: Kim, Minwook;Pugarelli, Joan;Miller, Thomas L.;Wolfson, Marla R.;Dodge, George R.;Shaffer, Thomas H.
• 通讯作者: Shaffer, Thomas H.

Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System.

• DOI: 10.1097/fjc.0000000000001236
• 发表时间: 2022-09-01
• 期刊: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
• 影响因子: 3
• 作者: Xu, Heli;Tilley, Douglas G.
• 通讯作者: Tilley, Douglas G.