Integrative Cardiovascular Pathophysiology

摘要/摘要 此续订申请请求为综合课程的博士后和博士后实习生提供支持 心血管病理生理学(ICVP)培训计划。ICVP培训中的教师导师 计划主要在心血管研究中心内进行预约(直接 由ICVP项目主任Steven Houser博士)或转化医学中心(指导 由天普大学医学院ICVP项目联席主任Walter Koch博士主持)。 我们计划的目的是为以下人员提供广泛的多学科培训经验 该领域的博士后研究员、博士后研究员和暑期医学生 综合心血管病理生理学(ICVP)ICVP教职员工与许多人住在一起 不同的基础科学和临床科室，但他们的研究实验室主要是 在一个新的医学研究中心的两个相邻楼层的CVRC和CTM内 大楼。ICVP调查员/导师对 心血管系统及引起心血管疾病的这些特性的异常变化 包括缺血性心脏病、高血压性心脏病、 动脉粥样硬化、缺血性血管疾病、代谢综合征和糖尿病心血管 疾病。研究生和博士后研究员将接受人类教育培训 生理学和病理生理学，辅以细胞和分子方面的高级培训 生物学和适当使用人类心血管疾病的动物模型。毕业生 学生和同事的研究项目将包括基本的和翻译的部分。学生们 研究员们将被期望研究超越单个分子和 在心血管疾病模型的背景下解决问题。其中的一部分 项目将在不同研究人员的实验室进行，确保学生 研究人员接触到不同的科学方法。所有受训人员都将参与活动 提高他们的助学金和稿件写作及口头交流能力。团体辅导 初级和高级教职员工将确保受训人员具备担任领导职务的良好资格 研究人员能够迅速将新知识转化为新的疗法或治疗的靶点。 将使用各种招聘策略来吸引不同的受训人员群体，以反映 我们国家的多样性。其目标是培养一批多元化的新博士。和博士后 能够满足国家对下一代生物医学科学家的需求的研究员 可以开发心血管疾病的治疗方法。

Summary/Abstract This renewal application requests support for pre- and post-doctoral trainees in an Integrated Cardiovascular Pathophysiology (ICVP) training program. Faculty mentors in the ICVP training program primarily have their appointments within the Cardiovascular Research Center (Directed by Dr. Steven Houser, ICVP program director) or the Center for Translational Medicine (directed by Dr. Walter Koch, Co-Director of the ICVP program) at Temple University School of Medicine. The purpose of our program is to provide a broad based multidisciplinary training experience for pre-doctoral fellows, post-doctoral fellows and summer medical students in the area of integrative cardiovascular pathophysiology (ICVP). ICVP faculty members reside with many different basic science and clinical Departments, but their research laboratories are largely within the CVRC and CTM which are housed on two adjacent floors of a new medical research building. ICVP investigators/mentors have related interests in fundamental properties of the cardiovascular system and the aberrant changes in these properties that cause cardiovascular dysfunction in diseases including ischemic heart disease, hypertensive heart disease, atherosclerosis, ischemic vascular disease, metabolic syndrome and diabetic cardiovascular diseases. Graduate students and post-doctoral fellows will receive didactic training in human physiology and pathophysiology, complemented by advanced training in cellular and molecular biology and the appropriate use of animal models of human cardiovascular disease. Graduate student and fellow research projects will have basic and translational components. The students and fellows will be expected to investigate problems that go beyond a single molecule and address questions within the context of cardiovascular disease models. Portions of these projects will be performed in the laboratories of different investigators, ensuring that students and fellows are exposed to varied scientific approaches. All trainees will be involved in activities to enhance their grant and manuscript writing and oral communication skills. Group mentoring by junior and senior faculty will ensure trainees are well qualified to assume positions as leading investigators able to rapidly translate new knowledge into new therapies or targets for therapies. A variety of recruiting strategies will be used to attract a diverse group of trainees that reflect the diversity of our country. The goal is to train a diverse group of new Ph.Ds. and post-doctoral fellows that are able to fill a national need for the next generation of biomedical scientists who can develop therapies for cardiovascular diseases..