Administrative Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]

行政核心 [父标题：在马拉维通过实施科学预防婴儿感染]

• 批准号: 10701192
• 负责人: MINA CHRISTINE HOSSEINIPOUR
• 金额: $ 20.31万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701192
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Caring; Childhood; Clinical; Clinical Trials Network; Collaborations; Collection; Communication; Communities; Data; Data Analytics; Data Science; Decision Making; Dedications; Electronic Mail; Ensure; Evaluation; Foundations; Funding; Goals; Grant; HIV; Health; Human Subject Research; Individual; Infant; Information Systems; Infrastructure; International Maternal Pediatric Adolescent AIDS Clinical Trials; Malawi; Manuscripts; Mission; Monitor; National Institute of Child Health and Human Development; Parents; Perinatal; Play; Policies; Preparation; Procedures; Program Evaluation; Progress Reports; Protocols documentation; Regimen; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Role; Safety; Schedule; Science; Site; Specimen; Training; Update; Woman; Work; biobank; cohort; implementation research; implementation science; implementation strategy; infant infection; instrument; meetings; operation; pre-exposure prophylaxis; pregnant; prevent; programs; research study; symposium; working group

Administrative Core – Summary The Administrative Core (Admin Core) for this program, “Preventing Infant Infection with Implementation Science in Malawi” (PRI3SM), will play a central role in achieving our overall objective to identify successful implementation strategies to eliminate MTCT (EMTCT) in Malawi and beyond. The Admin Core will oversee the operation, coordination, management, and evaluation of the three projects focused on the EMTCT cascade. We will join in crosscutting support with the implementation science core and data science and analytical core to provide advanced support and coordination to each of these study projects. The Admin Core will support the activities of the projects and cores to enhance the potential for cross protocol comparisons through harmonized instruments, data systems, and procedures. The Admin Core will also support Ministry of Health program evaluations and provide mechanisms for engagement of young investigators through existing capacity building programs. Through the existing infrastructure of UNC Project Malawi, the Admin Core will assist all core and project directors with operational and budgetary oversight and management, including submission of progress reports, communication between EMTCT clinical, research, policy and implementing partners and communication with NICHD. The core will organize activities that enhance collaborations between both senior and junior investigators based at UNC-CH, UNC Project Malawi, the Malawi Ministry of Health and PEPFAR implementing partners. These synergistic and mature relationships have been developed over the past twenty years of EMTCT activities in Malawi beginning with a collaboration with the Malawi MOH and the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) to implement HIVNET012 regimen in 2002; the establishment of DAIDS network clinical trials including the IMPAACT network; numerous single site research activities through CDC (the BAN study) and NICHD funding; and an increasing number of implementation science trials0. Most importantly, policy and practice changes have led to well-established relationships with the Malawi Ministry of Health and implementing partners. The Admin Core will also assemble and facilitate meetings of both an External and Internal Advisory Board, and coordinate participation in annual local and global EMTCT meetings. The Admin Core will ensure that overall goals for the program are accomplished as outlined below. Aim 1. Enhance the program effort by optimizing communication, decision-making and sharing among the research project teams, the support cores and the implementing partners. Aim 2. Develop and maintain shared, dedicated administrative infrastructure to ensure timely and accurate monitoring, reporting, and regulatory compliance of all EMTCT activities. Aim 3. Provide administrative support to strengthen existing partnerships in Malawi, between UNC Project, Malawi Ministry of Health, PEPFAR implementing partners and community partners.

行政核心-摘要 该计划的管理核心（管理核心）“通过实施预防婴儿感染 马拉维科学”（PRI 3SM）将在实现我们的总体目标方面发挥核心作用， 在马拉维及其他地区消除儿童经母体感染艾滋病毒/艾滋病的战略。管理核心将监督 以消除母婴传播为重点的三个项目的运作、协调、管理和评估 级联。我们将加入与实施科学核心和数据科学的交叉支持， 分析核心，为每个研究项目提供先进的支持和协调。管理核心 将支持项目和核心的活动，以提高跨方案比较的潜力 通过统一的工具、数据系统和程序。行政核心还将支持 健康计划评估，并通过现有的机制， 能力建设方案。 管理核心将通过马拉维项目的现有基础设施，协助所有核心和项目 负责业务和预算监督和管理的主任，包括提交进度报告， 消除母婴传播的临床、研究、政策和执行伙伴之间的沟通， NICHD。核心将组织活动，加强高年级和低年级之间的合作 联合国儿童基金会、马拉维艾滋病项目、马拉维卫生部和PEPFAR的调查人员 执行伙伴。这些协同和成熟的关系已经在过去的二十年中发展起来， 在马拉维开展了多年的消除母婴传播活动，首先与马拉维卫生部和伊丽莎白 格拉泽儿童艾滋病基金会于2002年实施HIVNET 012方案; DAIDS网络临床试验，包括IMPAACT网络;通过 CDC（BAN研究）和NICHD资助;以及越来越多的实施科学试验0。最 重要的是，政策和实践的变化导致与马拉维农业部建立了良好的关系， 保健和执行伙伴。行政核心还将召集和促进双方的会议 外部和内部咨询委员会，并协调参加地方和全球消除母婴传播疾病年度会议。 管理核心将确保该计划的总体目标完成如下所述。 目标1.通过优化沟通、决策和共享， 研究项目小组、支助核心和执行伙伴。 目标二。开发和维护共享的专用行政基础设施，以确保及时和准确地 监测、报告和遵守所有消除母婴传播活动的法规。 目标3。提供行政支助，以加强马拉维的现有伙伴关系， 马拉维卫生部、总统艾滋病紧急救援计划执行伙伴和社区伙伴。