Administrative Core [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]

管理核心-摘要 该项目的管理核心(管理核心)：通过实施来预防婴儿感染 马拉维的科学“(PRI3SM)将在实现我们确定成功的总体目标方面发挥核心作用。 在马拉维及其他地区消除母婴传播(EMTCT)的实施战略。管理核心将监督 三个项目的运作、协调、管理和评价的重点是紧急医疗事故 卡斯卡德。我们将与实施科学核心和数据科学一起加入横切支持 分析核心，为这些研究项目中的每一个提供高级支持和协调。管理核心 将支持项目和核心的活动，以增强跨议定书比较的潜力 通过统一的文书、数据系统和程序。管理核心还将支持 卫生方案评估，并提供机制，通过现有的 能力建设方案。 通过联合国马拉维项目的现有基础设施，行政核心将协助所有核心和项目 负责业务和预算监督和管理的董事，包括提交进度报告； EMTCT临床、研究、政策和实施合作伙伴之间的沟通，以及与 NICHD。核心组织将组织活动，加强高级和初级之间的合作 驻联合国儿童基金会、联合国儿童基金会马拉维项目、马拉维卫生部和PEPFAR的调查人员 执行伙伴。这些协同和成熟的关系是在过去的二十年里发展起来的。 多年来在马拉维开展的紧急母婴传播活动，始于马拉维卫生部和伊丽莎白基金会的合作 格拉泽儿童艾滋病基金会(EGPAF)于2002年实施HIVNET012方案；建立 DAIDS网络临床试验，包括IMPAACT网络；许多单点研究活动通过 CDC(禁毒令研究)和NICHD资金；以及越来越多的实施科学试验0。多数 重要的是，政策和做法的改变导致了与马拉维部的良好关系。 卫生和执行伙伴。管理核心还将召集和促进两个组织的会议 外部和内部咨询委员会，并协调参加当地和全球的紧急医疗保健措施的年度会议。 管理核心将确保实现计划的总体目标，如下所述。 目标1.通过优化以下人员之间的沟通、决策和共享来加强计划工作 研究项目团队、支助核心和执行伙伴。 目标2.开发和维护共享的专用行政基础设施，以确保及时和准确 监测、报告和遵守所有紧急医疗事故预防措施的活动。 目标3.提供行政支助，以加强马拉维现有的伙伴关系， 马拉维卫生部、PEPFAR实施伙伴和社区伙伴。

Administrative Core – Summary The Administrative Core (Admin Core) for this program, “Preventing Infant Infection with Implementation Science in Malawi” (PRI3SM), will play a central role in achieving our overall objective to identify successful implementation strategies to eliminate MTCT (EMTCT) in Malawi and beyond. The Admin Core will oversee the operation, coordination, management, and evaluation of the three projects focused on the EMTCT cascade. We will join in crosscutting support with the implementation science core and data science and analytical core to provide advanced support and coordination to each of these study projects. The Admin Core will support the activities of the projects and cores to enhance the potential for cross protocol comparisons through harmonized instruments, data systems, and procedures. The Admin Core will also support Ministry of Health program evaluations and provide mechanisms for engagement of young investigators through existing capacity building programs. Through the existing infrastructure of UNC Project Malawi, the Admin Core will assist all core and project directors with operational and budgetary oversight and management, including submission of progress reports, communication between EMTCT clinical, research, policy and implementing partners and communication with NICHD. The core will organize activities that enhance collaborations between both senior and junior investigators based at UNC-CH, UNC Project Malawi, the Malawi Ministry of Health and PEPFAR implementing partners. These synergistic and mature relationships have been developed over the past twenty years of EMTCT activities in Malawi beginning with a collaboration with the Malawi MOH and the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) to implement HIVNET012 regimen in 2002; the establishment of DAIDS network clinical trials including the IMPAACT network; numerous single site research activities through CDC (the BAN study) and NICHD funding; and an increasing number of implementation science trials0. Most importantly, policy and practice changes have led to well-established relationships with the Malawi Ministry of Health and implementing partners. The Admin Core will also assemble and facilitate meetings of both an External and Internal Advisory Board, and coordinate participation in annual local and global EMTCT meetings. The Admin Core will ensure that overall goals for the program are accomplished as outlined below. Aim 1. Enhance the program effort by optimizing communication, decision-making and sharing among the research project teams, the support cores and the implementing partners. Aim 2. Develop and maintain shared, dedicated administrative infrastructure to ensure timely and accurate monitoring, reporting, and regulatory compliance of all EMTCT activities. Aim 3. Provide administrative support to strengthen existing partnerships in Malawi, between UNC Project, Malawi Ministry of Health, PEPFAR implementing partners and community partners.