Building Heart, Lung, Blood and Sleep Diseases and Disorders Late-Stage Translation Phase 4 Research Capacity in Malawi

建立心脏，肺，血液和睡眠疾病和障碍后期翻译 马拉维第四阶段研究能力 项目摘要 非传染性疾病，包括心脏病、肺病、血液病和睡眠疾病， 疾病（HLBS）在全球范围内的患病率正在增加。在非洲，至关重要的是要有一个明确的 了解这些条件的负担和风险因素，以便设计环境 具体干预措施。在马拉维，尽管HLBS的负担越来越重， 当地相关的研究证据和大量科学家。拟议的方案将 建立可持续的以HLBS为重点的后期翻译阶段4研究（T4 TR）能力， 马拉维，并将利用这一能力对基础设施和疾病进行深入研究 负担需求评估，以设计特定于背景的HLBS T4 TR研究计划。的 应用程序汇集了已经参与HLBS培训的主要机构的联盟 在马拉维进行研究。该联合体的目的是建设联合国系统内的能力， 马拉维大学医学院（COM），该国唯一的公立医学院， 和马拉维卫生部，以确保可持续性。 该应用程序侧重于四个总体目标：1。技能发展活动， HLBS T4 TR能力COM的教师，研究生和研究生临床 卫生部和实施伙伴的受训人员和一线卫生工作者。这种技能 发展将利用两个联盟的正在进行的研究培训计划（ COM-北卡罗来纳州大学正在实施的科学培训计划（NIH D43 TW 010060 -01：M-HIRST）和泛非胸科学会，流行病学方法， 临床和运营研究（PATS-MECOR）计划由马拉维-利物浦领导 Wellcome Trust临床研究计划（MLW）这项技能发展计划将 辅以指导研究奖和实习计划， 实施现场。2.我们将在全国范围内开展深入的HLBS T4研究 利用简短的书面调查、设施访问和审计评估基础设施需求， 名义上的焦点小组讨论和电话访谈。3.疾病负担评估 将利用现有的疾病流行率调查数据， 部分调查和全面的文献综述。4.最后，我们将利用这些技能 发展活动以及需求评估的结果， 针对优先HLBS的全面、可操作且马拉维特定的T4 TR研究计划。 我们将利用地方、国家、区域和国际传播渠道， 项目经验和发现。

Building Heart, Lung, Blood and Sleep Diseases and Disorders Late-Stage Translation Phase 4 Research Capacity in Malawi Project Summary Non-communicable diseases (NCDs), including heart, lung, blood and sleeping diseases and disorders (HLBS) are increasing in prevalence globally. In Africa, it is crucial to have a clear understanding of the burden and risk factors for these conditions in order to design context specific interventions. In Malawi, despite the growing burden of HLBS, there is a shortage of locally relevant research evidence and a critical mass of scientists. The proposed program will build sustainable HLBS-focused late-stage translation phase 4 research (T4TR) capacity in Malawi and will utilize this capacity to do in-depth research of infrastructure and diseases burden needs assessments to design a context specific HLBS T4TR research plan. The application brings together a consortium of key institutions already involved in HLBS training and research in Malawi. The consortium is purposefully designed to build capacity within the University of Malawi-College of Medicine (COM), the only public medical school in the country, and the Malawi Ministry of Health (MoH), to ensure sustainability. This application focuses on four overarching aims: 1. Skills development activities to build HLBS T4TR capacity within COM's faculty, graduate students, and postgraduate clinical trainees and frontline health workers from MoH and implementation partners. This skills development will leverage two of the consortium's ongoing research training programs (the COM-University of North Carolina's ongoing implementation science training program (NIH D43 TW010060-01: M-HIRST) and the Pan African Thoracic Society, Methods in Epidemiologic, Clinical and Operations Research (PATS-MECOR) program led by the Malawi-Liverpool Wellcome Trust Clinical Research Programme (MLW). This skills development program will be supplemented by a mentored research awards and an internship program housed at partners' implementation sites. 2. We will conduct an in-depth national HLBS T4 research infrastructure needs assessment using short written surveys, facility visits and audits, nominal focus group discussions and telephone interviews. 3. A disease burden assessment will be conducted using existing data on disease prevalence surveys supplemented by cross- sectional surveys and thorough literature reviews. 4. Finally, we will utilize the skills development activities together with the findings of the needs assessments to create a comprehensive, actionable, and Malawi specific T4TR research plan for priority HLBS. We will utilize local, national, regional and international dissemination avenues to disseminate program experiences and findings.