Accelerating Medicines Partnership-Autoimmune and Immunologic Disease Tissue Research Core
加速药物合作——自身免疫和免疫疾病组织研究核心
基本信息
- 批准号:10687729
- 负责人:
- 金额:$ 14.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-23 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AttentionAutoimmuneAutoimmune DiseasesAwarenessBiological MarkersBiopsyBiotechnologyCaringCellsCertificationCharacteristicsCladribineClinicalCollectionCountryDataData SetDatabase Management SystemsDedicationsDiseaseEmerging TechnologiesEnsureEquipment and supply inventoriesFoundationsFreezingGovernmentHistologyImageImmuneImmune System DiseasesIndustry StandardInformation SystemsInfrastructureInstitutionInstitutional Review BoardsInternationalInvestmentsKnowledgeLeadershipLocationLogisticsLupusLupus ErythematosusManualsMeasurementMediatingMedical ResearchMedicineMethodsMissionModalityMolecularMolecular GeneticsMolecular ProfilingMonitorMultiomic DataOklahomaPathologyPatientsPhenotypePlayPositioning AttributeProceduresProcessProtocols documentationPsoriasisQuality ControlRecording of previous eventsResearchRheumatoid ArthritisSamplingScienceSecureServicesShippingShipsSiteSjogren&aposs SyndromeSolidStaff DevelopmentStandardizationSupport SystemSystemSystemic Lupus ErythematosusSystems IntegrationTechnologyTestingTissue BanksTissue SampleTissue imagingTissuesTrainingUniversitiesWorkadjudicationbiobankclinical applicationclinically actionablecohortcost effectivedesigndigital imagingdigital pathologydistributed dataexperiencehigh dimensionalityinnovationinterestmigrationmolecular phenotypemultiple omicspathology imagingphenotypic biomarkerprogramsrepositorysingle cell analysissocialsuccesstranscriptomics
项目摘要
Project Summary
The successful Accelerating Medicines Partnership in RA/Lupus (AMP1) program focused on deconstructing
disease tissues through single-cell transcriptomic technologies. AMP in Autoimmune and Immune-Mediated
Diseases (AMP AIM) is poised to expand the understanding of the cellular components and interactions at play
in four autoimmune disease target tissues with new spatially-oriented modalities of single-cell analyses. As in
the AMP1, the AMP AIM will require high-quality samples for interrogation, standardized methods to assess
sample quality and common molecular/phenotypic biomarker testing across all subjects for a clinically and
molecularly well-phenotyped cohort to apply new cutting-edge technologies to re-construct disease.
The OMRF tissue research core (TRC) is uniquely positioned to successfully deploy a centralized TRC
across all Disease Teams for Lupus (SLE), RA, Sjogren’s Disease (SjD), and Psoriatic Spectrum Diseases
(PSD). With a robust, existing infrastructure, capabilities, and leadership, the OMRF TRC will provide the
Network with: 1) standardized protocols and manuals to be used across all parts of the Network, 2) centralized
logistics for collection, transport, storage and dissemination, 3) centralized, trans-disease QC and initial testing
of all samples in a continuous manner as samples are collected for early quality management and identification
of samples of high importance, 4) tissue imaging (basic histology & initial high-dimensional) utilizing sample
sparing workflows that provide scoring and QC of tissue, plus initial multi-omic, spatially-informed data sets,
and 5) industry standard repository and image database systems.
The OMRF TRC is centrally located, making it an ideal location for logistics management and, since it was
the repository for AMP1 carries Network knowledge along with the extensive experience as repository for
multiple other national consortiums, provides for continuity during transition to AMP AIM. The OMRF TRC
already has infrastructure in place and the reputation that follows from strong leadership to continue to act as
an ideal honest broker for the Network. The OMRF TRC has state-of-the-art facilities that are integrated with
advanced technologies within its associated cores to receive, store, collect meaningful QC and initial data sets,
and disseminate selected samples to technology and analytic cores (TAC) poised to provide data from
emerging technologies to build upon the deep clinical and initial characterization data, to make extremely high-
dimensional, robust datasets.
Considering the longstanding history of the OMRF TRC in biobanking samples for autoimmune disease
studies, the OMRF TRC is poised to a produce a solid foundation of banked samples, organized logistics, and
initial multi-omic datasets that will setup the Network for success in reconstructing our mechanistic
understanding and clinical application of these new data to better treat these autoimmune diseases.
项目摘要
成功的加速RA/狼疮药物合作伙伴关系(AMP1)计划专注于解构
通过单细胞转录组学技术研究疾病组织。AMP在自身免疫和免疫介导的
疾病(AMP AIM)有望扩大对细胞成分和相互作用的理解
在四种自身免疫性疾病靶组织中使用新的空间定向的单细胞分析模式。如在
AMP AIM将需要高质量的样品进行询问,标准化的方法来评估
所有受试者的样本质量和常见分子/表型生物标志物检测,
分子表型良好的队列应用新的尖端技术来重建疾病。
OMRF组织研究中心(TRC)的独特定位是成功部署集中式TRC
狼疮(SLE)、类风湿性关节炎(RA)、干燥病(SjD)和银屑病谱系疾病的所有疾病团队
(私营部门司)。凭借强大的现有基础设施、能力和领导力,OMRF TRC将提供
网络具有:1)标准化协议和手册,用于网络的所有部分,2)集中式
收集、运输、储存和传播的物流,3)集中的跨疾病QC和初始检测
持续收集所有样品,以便进行早期质量管理和鉴定
4)组织成像(基本组织学和初始高维),
保留提供组织评分和质量控制的工作流程,以及初始多组学、空间信息数据集,
以及5)工业标准存储库和图像数据库系统。
OMRF TRC位于市中心,是物流管理的理想场所,
AMP 1的存储库沿着网络知识,并具有丰富的经验,
在向AMP AIM过渡期间提供连续性。OMRF TRC
已经有了基础设施,以及强有力的领导所带来的声誉,继续作为
一个理想的诚实的经纪人为网络。OMRF TRC拥有最先进的设施,
在其相关核心内采用先进技术,以接收、存储、收集有意义的QC和初始数据集,
并将选定的样本分发给技术和分析核心(TAC),
新兴技术建立在深入的临床和初始表征数据的基础上,
多维的强大数据集。
考虑到OMRF TRC在自身免疫性疾病生物库样本中的长期历史
研究,OMRF TRC准备为库存样品,有组织的物流,
初始多组学数据集,将设置网络,以成功重建我们的机制
这些新数据的理解和临床应用,以更好地治疗这些自身免疫性疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Joel Marvin Guthridge其他文献
Joel Marvin Guthridge的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Joel Marvin Guthridge', 18)}}的其他基金
Mechanisms of New-Onset Autoimmunity/Longitudinal Immune Systems Analysis (MONA-LISA)
新发自身免疫/纵向免疫系统分析(MONA-LISA)的机制
- 批准号:
10655219 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Accelerating Medicines Partnership-Autoimmune and Immunologic Disease Tissue Research Core Admin Supplement: Preclinical Studies in Sjogren's
加速药物合作 - 自身免疫和免疫疾病组织研究核心管理补充:干燥病的临床前研究
- 批准号:
10834635 - 财政年份:2022
- 资助金额:
$ 14.13万 - 项目类别:
Accelerating Medicines Partnership-Autoimmune and Immunologic Disease Tissue Research Core
加速药物合作——自身免疫和免疫疾病组织研究核心
- 批准号:
10452026 - 财政年份:2022
- 资助金额:
$ 14.13万 - 项目类别:
Accelerating Medicines Partnership-Autoimmune and Immunologic Disease Tissue Research Core
加速药物合作——自身免疫和免疫疾病组织研究核心
- 批准号:
10596177 - 财政年份:2022
- 资助金额:
$ 14.13万 - 项目类别:
Ikaros family genes and lupus susceptibility across ethnically diverse populations
Ikaros 家族基因和不同种族人群的狼疮易感性
- 批准号:
9770772 - 财政年份:2018
- 资助金额:
$ 14.13万 - 项目类别:
Ikaros family genes and lupus susceptibility across ethnically diverse populations
Ikaros 家族基因和不同种族人群的狼疮易感性
- 批准号:
10238826 - 财政年份:2018
- 资助金额:
$ 14.13万 - 项目类别:
相似国自然基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
- 批准号:31171277
- 批准年份:2011
- 资助金额:60.0 万元
- 项目类别:面上项目
相似海外基金
Autoantibodies and antibody-secreting cells in neurological autoimmune diseases: from biology to therapy
神经性自身免疫性疾病中的自身抗体和抗体分泌细胞:从生物学到治疗
- 批准号:
479128 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Operating Grants
Effects of maternal immune activation on autoimmune diseases in offsprings
母体免疫激活对后代自身免疫性疾病的影响
- 批准号:
23H02155 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
IPP: AUTOIMMUNE DISEASES STATISTICAL AND CLINICAL COORDINATING CENTER (ADSCCC)
IPP:自身免疫性疾病统计和临床协调中心 (ADSCCC)
- 批准号:
10788032 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Biomarkers of vascular endothelial dysfunction in systemic autoimmune diseases: analysis of circulating microRNAs
系统性自身免疫性疾病中血管内皮功能障碍的生物标志物:循环 microRNA 分析
- 批准号:
23K14742 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
NOVEL HUMORAL AND CELLULAR BIOMARKERS OF AUTOIMMUNE DISEASES CAUSED BY IMMUNOTHERAPY
免疫治疗引起的自身免疫性疾病的新型体液和细胞生物标志物
- 批准号:
10593224 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Structural mechanisms of autoimmune diseases targeting cys-loop receptors
针对半胱氨酸环受体的自身免疫性疾病的结构机制
- 批准号:
10864719 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Developing non-immunosuppressive immune-based therapeutics for targeted treatment of autoimmune diseases
开发非免疫抑制性免疫疗法来靶向治疗自身免疫性疾病
- 批准号:
10586562 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Regulation of autoimmune diseases by PTPN22 phosphatase
PTPN22磷酸酶对自身免疫性疾病的调节
- 批准号:
23K06589 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Decipher and target GABA metabolism and GABA receptor-mediated signaling in autoimmune diseases
破译并靶向自身免疫性疾病中的 GABA 代谢和 GABA 受体介导的信号传导
- 批准号:
10623380 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别:
Targeting the long isoform of the prolactin receptor to treat autoimmune diseases and B-cell malignancies
靶向催乳素受体的长亚型来治疗自身免疫性疾病和 B 细胞恶性肿瘤
- 批准号:
10735148 - 财政年份:2023
- 资助金额:
$ 14.13万 - 项目类别: