Coronavirus Immunoassay Core

冠状病毒免疫测定核心

• 批准号: 10688390
• 负责人: JAMES E Robinson
• 金额: $ 37.3万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688390
• 关键词: 2019-nCoV; Acetone; Antibodies; Antibody Response; Antibody-mediated protection; Area; Binding; Biological Assay; COVID-19 detection; Cancer Patient; Cells; Collaborations; Coronavirus; Enzyme-Linked Immunosorbent Assay; Equipment; Feasibility Studies; Goals; Health Sciences; Immune response; Immunoassay; Immunoglobulin G; Immunologic Memory; Immunology; Infection; Institution; Laboratories; Methanol; Monoclonal Antibodies; Neutralizing antibody assay; Performance; Plasma; Population; Population Group; Proteins; Reagent; Recombinants; Reproducibility of Results; Research Personnel; Resources; SARS-CoV-2 antibody; SARS-CoV-2 infection; Serology; Serology test; Seroprevalences; Serum; Services; Slide; Standardization; Study Subject; T cell response; Universities; Viral Proteins; Virus; Washington; antibody detection; coronavirus disease; experimental study; follow-up; human coronavirus; human monoclonal antibodies; human subject; innovation; screening; seasonal coronavirus; seropositive; tool; viral resistance

Immunology Core Summary The overall objective of the Immunoassay core is to provide high quality materials that will make feasible the studies proposed in projects 1 and 2, and especially to assure that studies are using reagents and pretested materials that will produce reliable and reproducible results. The core will provide purified recombinant viral proteins for use in both projects and provide binding and functional immunoassays for in depth analysis of antibody responses to SARS CoV-2 in different population groups over a period of follow-up. The core is made up of two labs, one at Tulane and one at WSU, which will function in close collaboration to achieve our aims

免疫学核心摘要 免疫测定核心的总体目标是提供高质量的材料，使其可行 在项目1和2中提出的研究，尤其是为了确保研究正在使用试剂并进行了预先测试 将产生可靠且可重现结果的材料。核心将提供纯化的重组病毒 蛋白质用于两个项目，并提供具有约束力和功能性免疫测定，以深入分析 在随访的一段时间内，不同人群组中对SARS COV-2的抗体反应。核心是制造的 在两个实验室，一个在杜兰（Tulane）和一个在WSU的实验室，该实验室将密切合作以实现我们的目标