Culturally-targeted communication to promote SARS-CoV-2 antibody testing in saliva: Enabling evaluation of inflammatory pathways in COVID-19 racial disparities

项目摘要 非裔美国人发展和死于SARS-CoV-2感染比任何其他种族群体在美国 包括密歇根州弗林特等大多数非洲裔美国人城市。SARS-CoV-2差异源于 许多相互关联的原因。然而，在COVID-19的差异中， 仍然在很大程度上未知。SARS-CoV-2抗体可促进炎症反应的评估 测试，可用于识别和比较炎症之间的那些和没有确认 SARS-CoV-2感染，并进行炎症因子的跨种族比较。但非洲 由于对医学的不信任，美国人将不愿意参加传统的抗体检测项目， 种族主义的经历在COVID-19时代很突出。因此，迫切需要发展和 部署与文化相关的沟通和抗体检测计划。我们的长期目标是识别和 减少不公正的COVID-19种族差异。当前的目标是更好地鼓励理解， 接受SARS-CoV-2抗体检测。核心假设是，非洲裔美国人将接受 抗体检测时，好处和限制是在文化上有效的方式沟通，当 使用非侵入性唾液收集方法和测定。我们的理论是， 有效的健康沟通与唾液检测将减少不信任和促进吸收， 更好地把握炎症在COVID-19差异中的作用。我们的目标是1）发展和比较 关于非裔美国人和白色弗林特的抗体测试的一般视频与针对文化的视频的效果 居民的抗体检测态度和吸收; 2）识别和比较一般与文化的影响， 有针对性的视频激活医疗不信任和种族主义相关的认知非洲裔美国人， 考虑抗体检测; 3）测量和鉴定Flint中的多分析物炎症生物标志物谱 完成唾液抗体检测并比较炎症生物标志物特征的登记研究入组者， 种族和抗体状况与临床和社区合作伙伴合作，我们将准备和评估 关于SARS-CoV-2抗体检测的一般和针对文化的视频教程。这些简短的视频将 通过弗林特登记处分发给弗林特社区-一个高度可见的地方卫生资源交换所。 与领先的唾液生物科学专家合作，我们将提供一个机会， 唾液抗体筛查-一种非侵入性的抗体检测方法，非常适合于不一致性， 面向COVID-19研究。该研究具有创新性和重要意义，突出了文化- 有针对性的沟通和非侵入性抗体检测对于推动以医疗为导向的 煽动性的COVID-19研究。要获得的知识包括视频教程和见解， 面向社区的唾液收集，可以立即通过SeroNet传播，以更好地促进 包括正在进行的炎症和抗体测试研究中的种族监测。

Project Summary African Americans develop and die from SARS-CoV-2 infection more than any other racial group in the United States, including in majority African American cities such as Flint, Michigan. SARS-CoV-2 disparities stem from many interconnected causes. Yet, connections to inflammatory biological processes in COVID-19 disparities remain largely unknown. Evaluating inflammatory responses can be facilitated by SARS-CoV-2 antibody testing, which can be used to identify and compare inflammation among those with and without confirmed SARS-CoV-2 infection, and to conduct cross-race comparisons of inflammatory factors. However, African Americans will be reluctant to partake in conventional antibody testing programs due to medical mistrust and experiences with racism that are salient in the COVID-19 era. There is thus an urgent need to develop and deploy culturally-relevant communication and antibody testing programs. Our long-term goal is to identify and reduce unjust COVID-19 racial disparities. The immediate objective is to better encourage understanding and uptake of SARS-CoV-2 antibody testing. The central hypothesis is that African-Americans will be receptive to antibody testing when benefits and limitations are communicated in a culturally effective manner, and when non-invasive salivary collection methods and assays are used. Our rationale is that combining culturally effective health communication with salivary testing will reduce mistrust and promote uptake that can lead to better grasping the role of inflammation in COVID-19 disparities. Our aims are to 1) develop and compare effects of a general versus culturally-targeted video about antibody testing on African American and White Flint residents’ antibody testing attitudes and uptake; 2) identify and compare effects of a general versus culturally- targeted video on activation of medical mistrust and racism-related cognition among African Americans when considering antibody testing; 3) measure and identify multi-analyte inflammatory biomarker profiles among Flint Registry enrollees who complete salivary antibody testing and compare inflammatory biomarker profiles by race and antibody status. In collaboration with clinical and community partners, we will prepare and evaluate general and culturally-targeted video tutorials about SARS-CoV-2 antibody testing. These brief videos will be distributed to the Flint community through the Flint Registry – a highly visible local health resource exchange. In collaboration with leading salivary bioscience experts, we will furnish an opportunity to engage in at-home salivary antibody screening – a non-invasive route to antibody testing that is highly suited to disparities- oriented COVID-19 research. The proposed research is innovative and significant in highlighting that culturally- targeted communication and non-invasive antibody testing are vital to propelling disparities-oriented inflammatory COVID-19 research. Knowledge to be gained includes video tutorials and insights about community-facing salivary collection that can be immediately disseminated across SeroNet to better promote including racial monitories in ongoing studies of inflammation and antibody testing.