Culturally-targeted communication to promote SARS-CoV-2 antibody testing in saliva: Enabling evaluation of inflammatory pathways in COVID-19 racial disparities

项目摘要 非洲裔美国人死于SARS-CoV-2感染的人数比美国其他任何种族都要多 各州，包括密歇根州弗林特等非裔美国人占多数的城市。SARS-CoV-2差异源于 许多相互关联的原因。然而，新冠肺炎与炎症生物学过程的联系存在差异 在很大程度上仍然不为人知。SARS-CoV-2抗体可促进炎症反应的评估 检测，可用于识别和比较确诊患者和未确诊患者之间的炎症 SARS-CoV-2感染情况，并对炎症因子进行跨种族比较。然而，非洲人 美国人将不愿参加传统的抗体检测计划，因为医疗不信任和 在新冠肺炎时代突出的种族主义经历。因此，迫切需要发展和发展 部署与文化相关的沟通和抗体检测计划。我们的长期目标是识别和 缩小不公正的新冠肺炎种族差距。眼前的目标是更好地鼓励理解和 SARS-CoV-2抗体检测的摄入量。核心假设是非裔美国人会接受 当以文化有效的方式传达益处和限制时，以及何时进行抗体检测 采用非侵入性唾液采集方法和检测方法。我们的理论基础是文化上的结合 通过唾液检测进行有效的健康沟通将减少不信任并促进吸收，从而导致 更好地把握炎症在新冠肺炎差异中的作用。我们的目标是1)发展和比较 关于抗体检测的一般视频与文化目标视频对非裔美国人和白弗林特人的影响 居民的抗体检测态度和接受情况；2)确定和比较一般与文化- 关于在非裔美国人中激活医疗不信任和种族主义相关认知的有针对性的视频 考虑抗体检测；3)测量和鉴定弗林特人群中的多分析炎性生物标志物 完成唾液抗体测试并比较炎症生物标记物特征的注册注册者 种族和抗体状况。与临床和社区合作伙伴合作，我们将准备和评估 关于SARS-CoV-2抗体检测的一般性和有文化针对性的视频教程。这些简短的视频将是 通过弗林特登记处分发给弗林特社区，这是一个非常引人注目的当地卫生资源交流机构。 与领先的唾液生物科学专家合作，我们将提供一个在家中参与的机会 唾液抗体筛查-一种非常适合差异的非侵入性抗体检测方法- 面向新冠肺炎研究。拟议的研究具有创新性和重要意义，突出了文化上的-- 有针对性的沟通和非侵入性抗体检测对于推动以差异为导向的 新冠肺炎的煽动性研究。要获得的知识包括视频教程和关于以下内容的见解 面向社区的唾液收集，可以立即在SeroNet上传播，以更好地推广 在正在进行的炎症和抗体检测研究中包括种族监测。

Project Summary African Americans develop and die from SARS-CoV-2 infection more than any other racial group in the United States, including in majority African American cities such as Flint, Michigan. SARS-CoV-2 disparities stem from many interconnected causes. Yet, connections to inflammatory biological processes in COVID-19 disparities remain largely unknown. Evaluating inflammatory responses can be facilitated by SARS-CoV-2 antibody testing, which can be used to identify and compare inflammation among those with and without confirmed SARS-CoV-2 infection, and to conduct cross-race comparisons of inflammatory factors. However, African Americans will be reluctant to partake in conventional antibody testing programs due to medical mistrust and experiences with racism that are salient in the COVID-19 era. There is thus an urgent need to develop and deploy culturally-relevant communication and antibody testing programs. Our long-term goal is to identify and reduce unjust COVID-19 racial disparities. The immediate objective is to better encourage understanding and uptake of SARS-CoV-2 antibody testing. The central hypothesis is that African-Americans will be receptive to antibody testing when benefits and limitations are communicated in a culturally effective manner, and when non-invasive salivary collection methods and assays are used. Our rationale is that combining culturally effective health communication with salivary testing will reduce mistrust and promote uptake that can lead to better grasping the role of inflammation in COVID-19 disparities. Our aims are to 1) develop and compare effects of a general versus culturally-targeted video about antibody testing on African American and White Flint residents’ antibody testing attitudes and uptake; 2) identify and compare effects of a general versus culturally- targeted video on activation of medical mistrust and racism-related cognition among African Americans when considering antibody testing; 3) measure and identify multi-analyte inflammatory biomarker profiles among Flint Registry enrollees who complete salivary antibody testing and compare inflammatory biomarker profiles by race and antibody status. In collaboration with clinical and community partners, we will prepare and evaluate general and culturally-targeted video tutorials about SARS-CoV-2 antibody testing. These brief videos will be distributed to the Flint community through the Flint Registry – a highly visible local health resource exchange. In collaboration with leading salivary bioscience experts, we will furnish an opportunity to engage in at-home salivary antibody screening – a non-invasive route to antibody testing that is highly suited to disparities- oriented COVID-19 research. The proposed research is innovative and significant in highlighting that culturally- targeted communication and non-invasive antibody testing are vital to propelling disparities-oriented inflammatory COVID-19 research. Knowledge to be gained includes video tutorials and insights about community-facing salivary collection that can be immediately disseminated across SeroNet to better promote including racial monitories in ongoing studies of inflammation and antibody testing.