Genomic Competency Initiative

基因组能力计划

• 批准号: 10703129
• 负责人: Kathleen Calzone
• 金额: $ 10.53万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10703129
• 关键词: Address; Adopted; Advanced Practice Nurse; American; American Nurses' Association; Back; Biological; Canada; Certification; Collaborations; Community of Practice; Competence; Country; Data; Data Analyses; Delphi Study; Developing Countries; Development; Discipline of Nursing; Distance Education; Education; Educational Curriculum; England; European; European Union; Faculty; Finland; Funding; Genetic; Genomics; Goals; Graduate Degree; Grant; Guidelines; Health; Health education; Healthcare; Hospital Planning; Hospitals; Indiana; Institutes; Intervention; Knowledge; Leadership; Learning; Left; Licensure; Los Angeles; Malignant Neoplasms; Measures; Mentors; Methodology; Methods; Modeling; National Health Services; National Human Genome Research Institute; National Institute of Nursing Research; Natural regeneration; Nurse Midwives; Nurse Practitioners; Nurses; Nursing Education; Nursing Faculty; Nursing Research; Outcome; Output; Paper; Patient Recruitments; Pharmacogenomics; Phase; Postdoctoral Fellow; Precision Health; Protocols documentation; Published Comment; Publishing; Registered nurse; Regulatory Element; Reporting; Research; Research Personnel; Research Project Grants; Resources; Role; Sampling; Science; Scientist; Services; Strategic Planning; Stream; Surveys; Teacher Professional Development; Technology; Testing; Text; Time; Training; Training Programs; Translations; United Kingdom; United States National Institutes of Health; Universities; Update; Voting; Wales; Work; Workforce Development; academic preparation; arm; base; clinical practice; college; coronavirus disease; design; digital; doctoral student; education planning; evidence base; falls; follow-up; implementation study; instrument; international partnership; invention; medical specialties; meetings; pandemic disease; pilot test; recruit; science education; skills; success; symptom science; tool; training opportunity; university student; usability; web site; webinar

Project 1-Nursing Capacity in Pharmacogenomics: The national study of advanced practice nurses assessing pharmacogenomic capacity is being done collaboration with Dr. Cathy Fulton at Indiana University. The instrument was pilot tested and the protocol approved as Exempt at Indiana University and the NIH 000990. The study recruited participants from the Coalition of Advanced Practice Registered Nurses of Indiana (CAPNI) and the American Association of Nursing Practitioners annual meeting. CAPNI, disseminated the survey electronically will end recruitment in August 2022. Once CAPNI completes recruitment data analysis will begin. Thus far we been unsuccessful in having the American Association of Colleges of Nursing disseminate a faculty specific pharmacogenomic survey. We are exploring other mechanisms to gather faculty data on pharmacogenomic capacity and curricular content. Project 2-Omics Nursing Science and Education Network (ONSEN): The National Institute of Nursing Research (NINR) Director has changed. The current director changed NINR reserarch priorities to not include genomics or other biologic correlatives. The new strategic plan reflects this direction and NINR funding for studies that include biologic correlatives has been discontinued as has the Summer Genetics Institute (SGI). The intramural symptom science investigators have left NINR. Funding for the ONSEN was discontinued and the website is being taken down though I have navigated moving the website to the University of Pittsburgh (UPitt). The National Human Genome Research Institute (NHGRI) asked me to update the Genomic Nursing Science Blueprint. I discussed that NINR will not participate and there is no mechanism to both train nursing scientists to integrate genomics into their research nor a funding stream to support this work. NHGRI asked the NINR Director to speak at Council and Drs. Brody and Green plan to meet with her in follow-up given concerns they have and I have met with Dr. Brody at his request to provide some background information. I am moving forward with the Blueprint on a global scale through G2NA (Project 3) and will work with UPitt to expand ONSEN for global use. If there is a US funding stream for genomic nursing science (many are symptom science) then I will explore mechanisms for regenerating the Summer Genetics Institute as a possible NCI/NHGRI collaboration. Project 3-Global Genomics Nursing Alliance (G2NA): G2NA, established in 2017 has grown to 146 nursing leaders. The G2NA website https://g2na.org/ has funding and support from the University of South Wales (USW); sustains quarterly education webinars; grown the countries represented; established a strategic plan; communicates through a listserv; completed or are conducting research projects described below. Three Communities of Practice received the most votes from G2NA constituents to move forward: Workforce Development; Clinical Practice; and Overcoming Barriers. However, the pandemic has slowed the launch. The current action plan is to launch one and evaluate success. Two primary research outputs from G2NA, the Roadmap and the Maturity Matrix have both been adopted by England National Health Service and Health Education England in their country wide genomic implementation initiative. This effort is still in the early phases, i.e. the faculty training program was July 2022 despite being planned 3 years ago. As this implementation moves ahead, large scale usability data on the Maturity Matrix and Roadmap will be conducted to refine both tools. Establishing a Global Genomic Nursing Science Blueprint is still in place but delayed. This project starts with a systematic evidence review with a doctoral student from USW working with me. She had both personal and health problems but is finally back at it. But we needed an updated search. The first 6388 papers have had abstract reviews. The second updated search is in Covidence and there are 5 reviewers. 995 new abstracts need review, 331 have 1 vote and 490 full text in Covidence need review. The plan is to have the remainder of abstracts/papers reviewed by October 1. The doctoral student will coalesce the evidence at which time G2NA will convene a panel to establish a Global Genomic Nursing Research Blueprint. The project to establish the Global Minimal Genomic Competencies for nurses and midwives was unable to move ahead in this reporting period due to COVID as panelists include academic educators who had to transition to and back out of remote education. Methods have been established and the project now will launch late fall 2022 or spring 2023. Lastly, a team from Finland, United Kingdom, Canada and myself a COST Action European Union grant which provides funding for European and global research and capacity building initiatives. This will be submitted 10/2022 with 15 country partners besides the submission team. If funded, this will facilitate the ability to convene the meetings for establishing the Blueprint but also a research consortium and genomic capacity building initiatives and establishing evidence-based best practices and a resource toolkit. Project 4-The Genomic Nursing Competency (GNC) Update: With my collaborator Laurie Badzek, we submitted a proposal to the American Nurses Association for a national nursing precision health and genomic competency initiative which was approved and has launched. The previously updated but not published Genomic Nursing Competencies will be disseminated for public comment in August 2022. Changes will be integrated, and ANA will digitally publish them followed by integration into Scope and Standards of Practice so the existence of Competencies will no longer be required. ANA is also supporting the update the Genetic and Genomic Competencies for Graduate Nurses. This will use the same methodology as the original competency update, a Delphi study. The Delphi reviewers have been selected and the list approved by ANA. Invitations will be go out September, 2022. The Delphi Survey will launch once the Delphi panel is fully populated. Competencies will be revised based on the findings of the different rounds to Delphi, then disseminated for public comment and digitally published once all comments are addressed followed by integration into Scope and Standards. An additional project arm is to conduct a national precision health and genomics nursing competency assessment to inform whether a national nursing genomic education initiative is required. The genomics questions will use the Genetic and Genomic Nursing Practice Survey (my instrument). Questions for precision health are being crafted and validated by the Precision Health team. Once completed with regulatory review and approval, the survey will be disseminated as a single instrument. The decision about education inventions will be determined based on the findings. A genomic implementation study will be conducted at Cedars Sinai building on my original MINC study and use the Roadmap and Maturity Matrix Tool. MINC-2 will be cancer focused and a phased project. Phase 1 will be conducted at the primary Cedars in Los Angeles. Phase 2 will roll out to all hospitals with cancer services within the Cedars conglomerate. This project will measure competency and implementation at baseline and at the conclusion of the study and compare usual hospital planned education/competency initiatives to the intervention same hospital. Cedars leadership approval is in place. A genomic post doc funded by NHGRI and ACMG has been with me and our Cedars collaborator B *TRUNCATED*

项目1：药物基因组学中的护理能力：与印第安纳大学的Cathy Fulton博士合作，对评估药物基因组学能力的高级执业护士进行了全国性研究。该仪器已在印第安纳大学和美国国立卫生研究院000990进行了试点测试，并批准了豁免协议。该研究招募了来自印第安纳州高级执业注册护士联盟（CAPNI）和美国护理从业者协会年会的参与者。CAPNI以电子方式发布的调查将于2022年8月结束招聘。一旦CAPNI完成招聘数据分析将开始。到目前为止，我们还没有成功地让美国护理学院协会传播一项针对全体教员的药物基因组学调查。我们正在探索其他机制来收集有关药物基因组学能力和课程内容的教员数据。项目2组学护理科学与教育网络（ONSEN）：国家护理研究所（NINR）主任更换。现任主任改变了国家生物研究所的研究重点，不再包括基因组学或其他相关生物学。新的战略计划反映了这一方向，NINR和夏季遗传学研究所（SGI）都停止了对包括生物学相关性在内的研究的资助。校内的症状科学研究人员已经离开了nir。ONSEN的资助被终止了，网站也被关闭了，尽管我已经把网站搬到了匹兹堡大学（UPitt）。国家人类基因组研究所（NHGRI）要求我更新基因组护理科学蓝图。我讨论了国家护理研究中心不会参与，也没有机制来培训护理科学家将基因组学整合到他们的研究中，也没有资金流来支持这项工作。NHGRI请NINR主任在理事会上发言。考虑到他们的担忧，布罗迪和格林计划在后续工作中与她会面，我已应布罗迪博士的要求与他会面，以提供一些背景信息。我正在通过G2NA（项目3）在全球范围内推进蓝图，并将与UPitt合作将ONSEN扩展到全球使用。如果美国有基因组护理科学的资金流（许多是症状科学），那么我将探索将夏季遗传学研究所作为NCI/NHGRI合作的可能机制。全球基因组学护理联盟（G2NA）： G2NA成立于2017年，目前已发展到146名护理领导者。G2NA网站https://g2na.org/得到南威尔士大学（USW）的资助和支持；维持季度教育网络研讨会；发展所代表的国家；制定战略计划；通过列表服务器进行通信；已完成或正在进行下列研究项目。三个实践社区从G2NA成员中获得了最多的选票：劳动力发展；临床实践;克服障碍。然而，大流行减缓了启动速度。目前的行动计划是启动一个并评估成功。G2NA的两项主要研究成果，即路线图和成熟度矩阵，均已被英格兰国民保健服务和英格兰健康教育在其全国基因组实施倡议中采用。这一努力仍处于早期阶段，即教师培训计划尽管在三年前就计划好了，但到2022年7月才开始。随着实现的推进，成熟度矩阵和路线图上的大规模可用性数据将被用于改进这两个工具。建立全球基因组护理科学蓝图仍然存在，但被推迟了。这个项目从一个系统的证据审查开始，由一个来自USW的博士生和我一起工作。她个人和健康都有问题，但最终还是恢复了。但我们需要更新搜索结果。首批6388篇论文已经进行了摘要综述。第二个更新的搜索是在covid中，有5个审稿人。新增摘要审评995篇，1票331篇，全文审评490篇。计划是在10月1日之前对剩余的摘要/论文进行评审。博士生将汇集证据，届时G2NA将召集一个小组，建立全球基因组护理研究蓝图。由于新冠肺炎疫情，为护士和助产士建立全球最低基因组能力的项目无法在本报告所述期间取得进展，因为小组成员包括必须过渡到远程教育和退出远程教育的学术教育工作者。方法已经确定，该项目将于2022年秋末或2023年春季启动。最后，来自芬兰、英国、加拿大和我自己的一个团队获得了欧盟成本行动赠款，为欧洲和全球的研究和能力建设倡议提供资金。除提交团队外，该报告将于2022年10月与15个国家的合作伙伴一起提交。如果得到资助，这将有助于召开会议以制定蓝图，也有助于建立一个研究联盟和基因组能力建设倡议，并建立基于证据的最佳实践和资源工具包。项目四：基因组护理能力（GNC）更新：与我的合作者Laurie Badzek一起，我们向美国护士协会提交了一份关于国家护理精准健康和基因组能力倡议的提案，该倡议已被批准并启动。先前更新但未发布的基因组护理能力将于2022年8月发布以征求公众意见。变更将被整合，ANA将以数字方式发布，然后将其整合到范围和实践标准中，因此不再需要能力的存在。ANA还支持更新研究生护士的遗传和基因组能力。这将使用与原始能力更新相同的方法，即德尔菲研究。德尔福审稿人已选定，名单由全日空批准。邀请函将于2022年9月发出。德尔菲调查将在德尔菲面板填满后启动。能力将根据德尔福不同轮的调查结果进行修订，然后传播以征求公众意见，并在所有意见得到解决后以数字方式发布，随后整合到范围和标准中。另一个项目部门是开展全国精确保健和基因组学护理能力评估，以确定是否需要开展全国护理基因组教育倡议。基因组学问题将使用遗传和基因组护理实践调查（我的仪器）。精确运行状况团队正在编写和验证有关精确运行状况的问题。一旦完成监管审查和批准，调查将作为一个单一的工具传播。教育发明的决定将根据研究结果来决定。在我最初的MINC研究的基础上，将在雪松西奈进行基因组实施研究，并使用路线图和成熟度矩阵工具。MINC-2将以癌症为重点，是一个分阶段的项目。第一阶段将在洛杉矶的雪松初级医院进行。第二阶段将推广到雪松集团旗下所有提供癌症服务的医院。该项目将在基线和研究结束时衡量能力和执行情况，并将医院通常计划的教育/能力举措与同一医院的干预措施进行比较。雪松的领导层已经批准了。一名由NHGRI和ACMG资助的基因组博士后一直陪伴着我和我们的雪松合作伙伴B *TRUNCATED*