CD101 controls intraepithelial cells (IELs) for intestinal barrier integrity

CD101 控制上皮内细胞 (IEL) 维持肠道屏障完整性

• 批准号: 10702680
• 负责人: Chuan Wu
• 金额: $ 55.73万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10702680
• 关键词: Antigens; CD4 Positive T Lymphocytes; Cell physiology; Cells; Enterocytes; Epithelial; Epithelial Cells; Homeostasis; Immune; Immune Tolerance; Intestines; Microbe; Molecular; Mus; Play; Risk; Role; Signal Transduction; Symbiosis; T-Lymphocyte; dietary; gut inflammation; interest; intestinal barrier; intestinal epithelium; intestinal homeostasis; intraepithelial; response

IELs are known to be important for regulating intestinal barrier function, considering their close association with intestinal epithelial cells. The specific microenvironment of intestine determines the unique cellular and molecular features of IELs which potentially impact IELs function. We found that CD101 is highly expressed on IELs. We also found the loss of CD101 causes disrupted intestinal barrier and elevated bacterial invasion, leading to increased risk of intestinal inflammation. We are interested in studying molecular mechanisms of how CD101 controls IELs function to regulate intestinal barrier function.

众所周知，IEL对于调节肠屏障功能很重要， 它们与肠上皮细胞密切相关。具体的微环境 肠决定了IEL独特的细胞和分子特征， 影响IEL功能。我们发现CD101在IEL上高度表达。我们还发现 CD101的表达导致肠屏障破坏和细菌入侵增加，导致 增加肠道炎症的风险。我们对研究分子机制很感兴趣 CD101如何控制IEL功能以调节肠屏障功能。