The role of Foxo1 for intestinal epithelial cells during mucosal immune response

已知肠上皮细胞(IECS)与免疫细胞相互作用，调节肠道或全身免疫反应。树突状细胞(DC)是维持肠道免疫耐受的重要组成部分。然而，IECS和DC如何合作维持肠道免疫平衡仍不清楚。我们进一步发现转录因子Foxo1在IECS功能中起着关键作用。IECS内Foxo1的丢失导致粘液层形成和DC功能改变。因此，IECS中没有Foxo1的小鼠对肠道炎症的易感性增加。我们假设，IEC来源的Foxo1通过粘蛋白蛋白调节IEC-DC相互作用，从而导致肠道耐受。我们目前正在研究Foxo1调节IECS与DC相互作用的细胞和分子机制。

It is known that intestinal epithelial cells (IECs) interact with immune cells to modulate intestinal or systemic immune responses. Dendritic cells (DCs) are one crucial component in maintaining intestinal immune tolerance. However, how IECs and DCs collaborate to maintain the gut immune balance is still unclear. We further found that one transcription factor Foxo1, plays a critical role for IECs function. The loss of Foxo1 within IECs leads to altered mucus layer formation and DCs function. Consequently, mice without Foxo1 in IECs exhibit enhanced susceptibility to intestinal inflammation. We have hypothesized that IEC-derived Foxo1 regulates the IEC-DC interaction for intestinal tolerance via mucin protein. We are currently studying the cellular and molecular mechanisms of how Foxo1 regulates IECs interaction with DCs.