The role of Foxo1 for intestinal epithelial cells during mucosal immune response

已知肠上皮细胞（IEC）与免疫细胞相互作用， 调节肠道或全身免疫应答。树突状细胞（DC）是一种重要的 维持肠道免疫耐受。然而，独立选举委员会和发展中国家如何合作， 维持肠道免疫平衡仍不清楚。我们进一步发现， Foxo 1因子对IEC的功能起关键作用。IEC中Foxo 1的缺失导致 改变粘液层形成和DC功能。因此，IEC中没有Foxo 1的小鼠 对肠道炎症的易感性增强。我们假设 IEC衍生的Foxo 1通过粘蛋白调节IEC-DC相互作用以实现肠耐受。 我们目前正在研究Foxo 1如何调节IEC的细胞和分子机制 与DC的互动。

It is known that intestinal epithelial cells (IECs) interact with immune cells to modulate intestinal or systemic immune responses. Dendritic cells (DCs) are one crucial component in maintaining intestinal immune tolerance. However, how IECs and DCs collaborate to maintain the gut immune balance is still unclear. We further found that one transcription factor Foxo1, plays a critical role for IECs function. The loss of Foxo1 within IECs leads to altered mucus layer formation and DCs function. Consequently, mice without Foxo1 in IECs exhibit enhanced susceptibility to intestinal inflammation. We have hypothesized that IEC-derived Foxo1 regulates the IEC-DC interaction for intestinal tolerance via mucin protein. We are currently studying the cellular and molecular mechanisms of how Foxo1 regulates IECs interaction with DCs.