Immune-neuron crosstalk regulates intestinal homeostasis

免疫神经元串扰调节肠道稳态

• 批准号: 10926462
• 负责人: Chuan Wu
• 金额: $ 36.07万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10926462
• 关键词: Biological Response Modifiers; Cells; Chemicals; Communication; Complex; Cues; Data; Disease; Endocrine Glands; Enteric Nervous System; Environment; Esthesia; Gastrointestinal Diseases; Homeostasis; Host Defense; Immune; Immune system; Inflammation; Intestinal Mucosa; Intestines; Irritable Bowel Syndrome; Mediating; Molecular; Nerve; Nervous System; Neurons; Neurosecretory Systems; Organ; Physiology; Process; Sensory; Signal Transduction; Synaptic Transmission; System; Tissues; Translations; Work; detection platform; experience; gut-brain axis; intestinal barrier; intestinal homeostasis; microbiota; neuroregulation; response

Given that the gut functions as a major endocrine organ, the efficient translation from environmental cues to neuroendocrine responses is essential for body physiology. By harboring large quantities of microbiota and immune cells, the intestinal tissue is filled with a variety of immune regulators. Coordination between the immune system and the neuroendocrine system is essential for environmental sensation and host defense. Our work seeks to decipher the cellular and molecular mechanisms of immune-neural regulation for intestinal mucosal homeostasis. Further, the intestinal neuroendocrine responses are known to impact not only local but also systemic physiology. Our data establish that intestinal immune-mediated neuroendocrine responses orchestrate systemic physiology and inflammation.

鉴于肠道作为一个主要的内分泌器官，从环境线索到神经内分泌反应的有效翻译对身体生理学至关重要。通过窝藏大量的微生物群和免疫细胞，肠道组织充满了各种免疫调节剂。免疫系统和神经内分泌系统之间的协调对于环境感知和宿主防御至关重要。我们的工作旨在破译免疫神经调节肠粘膜稳态的细胞和分子机制。此外，已知肠道神经内分泌反应不仅影响局部生理学，而且影响全身生理学。我们的数据证实肠道免疫介导的神经内分泌反应协调全身生理学和炎症。