CD101 controls intraepithelial cells (IELs) for intestinal barrier integrity

考虑到IELs与肠上皮细胞的密切联系，IELs在调节肠道屏障功能方面具有重要作用。肠道的特殊微环境决定了IELs独特的细胞和分子特征，这些特征可能会影响IELs的功能。我们发现CD101在IEL上高度表达。我们还发现，CD101的丢失会导致肠道屏障的破坏和细菌侵袭的增加，从而增加肠道炎症的风险。我们有兴趣研究CD101如何调控IEL功能以调节肠屏障功能的分子机制。

IELs are known to be important for regulating intestinal barrier function, considering their close association with intestinal epithelial cells. The specific microenvironment of intestine determines the unique cellular and molecular features of IELs which potentially impact IELs function. We found that CD101 is highly expressed on IELs. We also found the loss of CD101 causes disrupted intestinal barrier and elevated bacterial invasion, leading to increased risk of intestinal inflammation. We are interested in studying molecular mechanisms of how CD101 controls IELs function to regulate intestinal barrier function.