CD101 controls intraepithelial cells (IELs) for intestinal barrier integrity

CD101 控制上皮内细胞 (IEL) 维持肠道屏障完整性

• 批准号: 10486983
• 负责人: Chuan Wu
• 金额: $ 54.88万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10486983
• 关键词: Antigens; CD4 Positive T Lymphocytes; Cell physiology; Cells; Enterocytes; Epithelial; Epithelial Cells; Homeostasis; Immune; Immune Tolerance; Intestines; Microbe; Molecular; Mus; Play; Risk; Role; Signal Transduction; Symbiosis; T-Lymphocyte; dietary; inflammatory disease of the intestine; interest; intestinal barrier; intestinal epithelium; intestinal homeostasis; intraepithelial; response

IELs are known to be important for regulating intestinal barrier function, considering their close association with intestinal epithelial cells. The specific microenvironment of intestine determines the unique cellular and molecular features of IELs which potentially impact IELs function. We found that CD101 is highly expressed on IELs. We also found the loss of CD101 causes disrupted intestinal barrier and elevated bacterial invasion, leading to increased risk of intestinal inflammation. We are interested in studying molecular mechanisms of how CD101 controls IELs function to regulate intestinal barrier function.

考虑到 IEL 与肠上皮细胞的密切相关性，已知 IEL 对于调节肠道屏障功能非常重要。肠道的特定微环境决定了 IEL 独特的细胞和分子特征，这可能会影响 IEL 的功能。我们发现 CD101 在 IEL 上高度表达。我们还发现 CD101 的缺失会导致肠道屏障破坏和细菌入侵增加，从而导致肠道炎症的风险增加。我们有兴趣研究 CD101 如何控制 IEL 功能以调节肠道屏障功能的分子机制。