HomeStyles: Shaping HOME Environments and LifeSTYLE Practices to Reduce Cardiometabolic Disease Risk
家居风格:塑造家庭环境和生活方式实践以降低心血管代谢疾病风险
基本信息
- 批准号:10693228
- 负责人:
- 金额:$ 67.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-24 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:2 arm randomized control trialAddressAdoptedAdultAnti-Inflammatory AgentsAsianAsian populationAttenuatedAwarenessBacteriaBehaviorBehavior TherapyBehavioralBody mass indexCardiometabolic DiseaseCharacteristicsChinaChineseChinese populationChronic DiseaseClinical TrialsCommunitiesConsumptionCountryDiabetes MellitusDietDietary FiberDietary InterventionDietary intakeDisease ProgressionDisparityEndotoxinsEthnic OriginFamilyFiberFocus GroupsFoodFruitGlycosylated hemoglobin AGoalsHealthHealth FoodHealth PromotionHealth StatusHealth behaviorHome environmentHomeostasisHypertensionImmigrationIndividualInflammationInflammatoryInterruptionInterventionIntervention StudiesInterviewKnowledgeLife StyleLinguisticsLinkMeasuresMinority GroupsModelingNational Institute on Minority Health and Health DisparitiesNew JerseyNew YorkNoiseNon-Insulin-Dependent Diabetes MellitusNutritionalObesityOnset of illnessOutcomeOverweightParticipantPatient Self-ReportPhysical activityPhysiologicalPlayPopulations at RiskPsychosocial StressRaceRandomizedRecommendationReportingResearchResearch Project GrantsRiskRisk FactorsRoleSelf EfficacyShapesSleepSleep DeprivationSpousesTestingTreatment EfficacyUnited States Department of AgricultureUnited States Preventative Services Task ForceVegetablesWorld Health Organizationcardiometabolic riskcardiometabolismclinically significantcognitive interviewcomorbiditycytokinedisorder riskefficacy testingevidence basegroup interventiongut bacteriagut healthgut microbiomegut microbiotahealth disparityhealth equityhealth inequalitieshealthy lifestyleimprovedinformantinterestmicrobiomemodifiable riskmulti-component interventionnutritionobesity riskpathobiontphysical inactivityprotective factorssleep behaviorsocial cognitive theorysocial health determinantssociodemographicssugarsystemic inflammatory responsetreatment groupwaist circumference
项目摘要
Research Project 1 – HomeStyles – Abstract
Individuals of Chinese heritage now are the largest and fastest growing segment of the US Asian population. US
Chinese have sociodemographic characteristics and culture that differ substantially from other US Asians, and
therefore, differ in social determinants of health, health status, and disease risk. US Chinese adults are at
increased risk for cardiometabolic disease, related conditions (obesity, type 2 diabetes mellitus, hypertension),
and systemic inflammation that promotes disease onset and progression. Immigration to a new country can
substantially impact the gut microbiome which may promote systemic inflammation.
Our pilot interventions indicate a high-fiber diet rich in whole grains reduced inflammation and
improved obesity. Additionally, our USDA supported, evidence based HomeStyles intervention has
demonstrated feasibility, acceptability, and efficacy in improving lifestyle behaviors and home
environments associated with obesity risk in families. A lack of linguistically, culturally tailored interventions
to their specific health needs makes it difficult for US Chinese to implement healthy lifestyle behaviors and reduce
health risks. We are not aware of any intervention tailored for US Chinese that could attenuate modifiable
cardiometabolic risk factors, understand physiological sequelae, and bridge health equity.
Thus, the overall goal of this R01 proposal is to test the efficacy of HomeStyles in improving health
outcomes in US Chinese in NY/NJ. Proposal aims are to: A) Culturally adapt the HomeStyles intervention
through community-engaged approaches. B) Conduct a 10-week, 2-armed RCT to test HomeStyles intervention
efficacy on health outcomes (dietary intake, physical activity, self-efficacy, HbA1C, waist circumference, and
BMI), hypothesizing that participants randomized to the treatment condition will have greater improvements in
health outcomes than control comparators. C) Examine associations between intervention participation and gut
microbiota/systemic inflammation and test hypotheses that a whole-grain rich diet adopted by those in the
intervention group will increase anti-inflammatory gut bacteria, reduce inflammatory gut bacteria, and lower
systemic inflammation.
This proposal’s aims parallel NIMHD’s specific interests, as well as RFA MD-21-007. This includes
interventions, like HomeStyles, that aim to ameliorate health inequities in minority populations and reduce
multiple common risk factors (e.g., obesity, poor nutrition, physical inactivity, insufficient sleep, systemic
inflammation) for multiple chronic diseases as well as address multi-generational chronic disease risk and
protective factors. A culturally adapted HomeStyles intervention holds great potential for improving our
knowledge about health disparity in the US Chinese population, understanding translational
mechanisms toward comorbidities, informing family and community-oriented interventions through
sustainable engagement, and serving as a model for health interventions for this audience.
研究项目1-家庭风格-摘要
中国血统的人现在是美国亚洲人口中规模最大、增长最快的部分。我们
中国人的社会人口特征和文化与其他美国亚洲人有很大不同,而且
因此,健康、健康状况和疾病风险的社会决定因素不同。美国中国成年人在
心脏代谢性疾病、相关疾病(肥胖、2型糖尿病、高血压)的风险增加,
以及促进疾病发生和发展的全身性炎症。移民到一个新国家可能会
极大地影响肠道微生物群,这可能会促进全身炎症。
我们的试点干预表明,富含全谷物的高纤维饮食可以减少炎症和
改善肥胖症。此外,我们的USDA支持的、基于证据的HomeStyles干预
证明了改善生活方式行为和家庭的可行性、可接受性和有效性
与家庭肥胖风险相关的环境。缺乏在语言和文化上量身定制的干预措施
他们的特定健康需求使美国华人难以实施健康的生活方式行为,并减少
健康风险。我们不知道有任何为美国中国人量身定做的干预措施可能会削弱可修改的
心脏代谢危险因素,了解生理后遗症,沟通健康公平。
因此,R01提案的总体目标是测试HomeStyles在改善健康方面的效果
在纽约/新泽西州的美国华人的结果。提案的目的是:a)从文化上适应家庭生活方式的干预
通过社区参与的方法。B)进行为期10周的双臂RCT,以测试HomeStyles干预
对健康结果的效果(饮食摄入量、体力活动、自我效能、糖化血红蛋白、腰围和
BMI),假设随机进入治疗条件的参与者将在
健康结果比对照对照的结果要好。C)审查干预参与度与体检之间的关系
微生物区系/全身性炎症和测试假设,全谷物丰富的饮食被那些
干预组将增加抗炎肠道细菌,减少炎性肠道细菌,并降低
全身炎症。
这项提案的目的与NIMHD的具体利益以及RFA MD-21-007相一致。这包括
像HomeStyles这样的干预措施,旨在改善少数群体中的健康不平等,并减少
多种常见危险因素(如肥胖、营养不良、缺乏体力活动、睡眠不足、系统性
炎症)用于多种慢性病,以及应对多代慢性病风险和
保护性因素。一种适应文化的家庭生活方式干预具有改善我们的
了解美国华裔人群的健康差距,了解翻译
共病机制,向家庭和社区提供信息,通过
可持续参与,并为这些受众提供健康干预的典范。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Debra Carol Byrd-Bredbenner其他文献
Debra Carol Byrd-Bredbenner的其他文献
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{{ truncateString('Debra Carol Byrd-Bredbenner', 18)}}的其他基金
HomeStyles: Shaping HOME Environments and LifeSTYLE Practices to Reduce Cardiometabolic Disease Risk
家居风格:塑造家庭环境和生活方式实践以降低心血管代谢疾病风险
- 批准号:
10437457 - 财政年份:2021
- 资助金额:
$ 67.09万 - 项目类别:
HomeStyles: Shaping HOME Environments and LifeSTYLE Practices to Reduce Cardiometabolic Disease Risk
家居风格:塑造家庭环境和生活方式实践以降低心血管代谢疾病风险
- 批准号:
10494161 - 财政年份:2021
- 资助金额:
$ 67.09万 - 项目类别:
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