HomeStyles: Shaping HOME Environments and LifeSTYLE Practices to Reduce Cardiometabolic Disease Risk

家居风格：塑造家庭环境和生活方式实践以降低心血管代谢疾病风险

• 批准号: 10494161
• 负责人: Debra Carol Byrd-Bredbenner
• 金额: $ 67.53万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494161
• 关键词: Address; Adopted; Adult; Advisory Committees; Anti-Inflammatory Agents; Asian; Asian population; Attenuated; Awareness; Bacteria; Behavior; Behavior Therapy; Behavioral; Body mass index; Cardiometabolic Disease; Characteristics; China; Chinese; Chinese population; Chronic Disease; Clinical Trials; Communities; Consumption; Country; Diabetes Mellitus; Diet; Dietary Fiber; Dietary Intervention; Dietary intake; Disease Progression; Endotoxins; Ethnic Origin; Family; Fiber; Focus Groups; Food; Generations; Glycosylated hemoglobin A; Goals; Health; Health Food; Health Promotion; Health Status; Health behavior; Home environment; Homeostasis; Hypertension; Immigration; Individual; Inflammation; Inflammatory; Interruption; Intervention; Intervention Studies; Interview; Knowledge; Lead; Life Style; Linguistics; Link; Measures; Minority Groups; Modeling; National Institute on Minority Health and Health Disparities; New Jersey; New York; Noise; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Obesity; Onset of illness; Outcome; Overweight; Participant; Patient Self-Report; Physical activity; Physiological; Play; Populations at Risk; Preventive service; Psychosocial Stress; Race; Randomized; Reporting; Research; Research Project Grants; Risk; Risk Factors; Role; Self Efficacy; Shapes; Sleep; Sleep Deprivation; Spouses; Testing; Treatment Efficacy; United States Department of Agriculture; World Health Organization; arm; base; cardiometabolic risk; cardiometabolism; clinically significant; cognitive interview; comorbidity; cytokine; disorder risk; efficacy testing; evidence base; fruits and vegetables; group intervention; gut bacteria; gut health; gut microbiome; gut microbiota; health disparity; health equity; health inequalities; healthy lifestyle; improved; informant; interest; microbiome; modifiable risk; multi-component intervention; nutrition; obesity risk; pathobiont; physical inactivity; protective factors; sleep behavior; social cognitive theory; social health determinants; sociodemographics; sugar; systemic inflammatory response; treatment group; waist circumference

Research Project 1 – HomeStyles – Abstract Individuals of Chinese heritage now are the largest and fastest growing segment of the US Asian population. US Chinese have sociodemographic characteristics and culture that differ substantially from other US Asians, and therefore, differ in social determinants of health, health status, and disease risk. US Chinese adults are at increased risk for cardiometabolic disease, related conditions (obesity, type 2 diabetes mellitus, hypertension), and systemic inflammation that promotes disease onset and progression. Immigration to a new country can substantially impact the gut microbiome which may promote systemic inflammation. Our pilot interventions indicate a high-fiber diet rich in whole grains reduced inflammation and improved obesity. Additionally, our USDA supported, evidence based HomeStyles intervention has demonstrated feasibility, acceptability, and efficacy in improving lifestyle behaviors and home environments associated with obesity risk in families. A lack of linguistically, culturally tailored interventions to their specific health needs makes it difficult for US Chinese to implement healthy lifestyle behaviors and reduce health risks. We are not aware of any intervention tailored for US Chinese that could attenuate modifiable cardiometabolic risk factors, understand physiological sequelae, and bridge health equity. Thus, the overall goal of this R01 proposal is to test the efficacy of HomeStyles in improving health outcomes in US Chinese in NY/NJ. Proposal aims are to: A) Culturally adapt the HomeStyles intervention through community-engaged approaches. B) Conduct a 10-week, 2-armed RCT to test HomeStyles intervention efficacy on health outcomes (dietary intake, physical activity, self-efficacy, HbA1C, waist circumference, and BMI), hypothesizing that participants randomized to the treatment condition will have greater improvements in health outcomes than control comparators. C) Examine associations between intervention participation and gut microbiota/systemic inflammation and test hypotheses that a whole-grain rich diet adopted by those in the intervention group will increase anti-inflammatory gut bacteria, reduce inflammatory gut bacteria, and lower systemic inflammation. This proposal’s aims parallel NIMHD’s specific interests, as well as RFA MD-21-007. This includes interventions, like HomeStyles, that aim to ameliorate health inequities in minority populations and reduce multiple common risk factors (e.g., obesity, poor nutrition, physical inactivity, insufficient sleep, systemic inflammation) for multiple chronic diseases as well as address multi-generational chronic disease risk and protective factors. A culturally adapted HomeStyles intervention holds great potential for improving our knowledge about health disparity in the US Chinese population, understanding translational mechanisms toward comorbidities, informing family and community-oriented interventions through sustainable engagement, and serving as a model for health interventions for this audience.

研究项目 1 – 家居风格 – 摘要 现在，华裔是美国亚裔人口中规模最大、增长最快的群体。我们 中国人的社会人口特征和文化与其他美国亚裔人有很大不同，并且 因此，健康、健康状况和疾病风险的社会决定因素有所不同。美国华裔成年人处于 心脏代谢疾病和相关疾病（肥胖、2 型糖尿病、高血压）的风险增加， 以及促进疾病发作和进展的全身炎症。移民到一个新的国家可以 严重影响肠道微生物群，可能促进全身炎症。 我们的试点干预措施表明，富含全谷物的高纤维饮食可以减少炎症和 改善肥胖。此外，我们美国农业部支持的、基于证据的家居风格干预措施已 证明了改善生活方式和家庭行为的可行性、可接受性和功效 与家庭肥胖风险相关的环境。缺乏针对语言和文化的干预措施 其特定的健康需求使得美国华人很难实施健康的生活方式行为并减少 健康风险。我们不知道有任何针对美国华人的干预措施可以减弱可修改的影响 心脏代谢危险因素，了解生理后遗症，并弥合健康公平。 因此，R01提案的总体目标是测试HomeStyles在改善健康方面的功效 纽约州/新泽西州的美国中文结果。提案的目的是： A) 在文化上适应家居风格干预 通过社区参与的方法。 B) 进行为期 10 周的 2 组 RCT 来测试 HomeStyles 干预 对健康结果的功效（饮食摄入量、体力活动、自我效能、HbA1C、腰围和 BMI），假设随机接受治疗条件的参与者将在以下方面有更大的改善 健康结果优于对照组。 C) 检查干预参与与肠道之间的关联 微生物群/全身炎症并测试假设，即人们采用的富含全麦的饮食 干预组将增加抗炎肠道细菌，减少炎症肠道细菌，并降低 全身炎症。 该提案的目标与 NIMHD 的具体利益以及 RFA MD-21-007 一致。这包括 像 HomeStyles 这样的干预措施旨在改善少数民族人口的健康不平等并减少 多种常见危险因素（例如肥胖、营养不良、缺乏身体活动、睡眠不足、全身性 炎症）治疗多种慢性疾病，并解决多代慢性疾病风险和 保护因素。适应文化的家居风格干预对于改善我们的生活具有巨大潜力 了解美国华人健康差异，理解转化 针对合并症的机制，通过以下方式告知家庭和社区导向的干预措施： 可持续参与，并作为该受众健康干预的典范。