Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic an Cognitive Predictors of Restorative Treatment Response

为失语症治疗的个性化医疗奠定基础:恢复性治疗反应的遗传和认知预测因素

基本信息

  • 批准号:
    10693204
  • 负责人:
  • 金额:
    $ 45.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Project Summary Incomplete understanding of patient-specific factors that determine whether someone will respond well to language therapy after stroke limits the development of methods to target or account for sources of variability. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. The long-term goal of this line of work is to maximize response to aphasia therapy by incorporating patient-specific factors into decisions related to treatment planning. The overall objective of this application is to identify patterns of patient-specific factors including two candidate genes and cognitive skills that show a relationship with treatment outcomes. The central hypothesis is that there will be a relationship between ApoE and BDNF genotypes, and working memory on stimulus generalization. The rationale for the proposed project is that the identification of factors that impact treatment responsiveness will allow for better estimation of prognosis, improved triage of individuals into appropriate therapy regimens and direct targeting of cognitive factors to maximize behavioral gains. The two specific aims of the project are to determine the degree to which (1) ApoE and BDNF genotypes influence how individuals with aphasia respond to therapy, and (2) working memory abilities are related to stimulus acquisition and stimulus generalization after anomia therapy. Individuals with chronic post-stroke aphasia will undergo cognitive and language assessment, and provide a saliva sample for genetic analysis prior to participating in a cued picture-naming therapy for anomia. The expected outcomes are to integrate cognitive scores and genotypes for BDNF and ApoE into formulating probabilities of individual patient responsiveness to restorative therapy. This contribution is expected to be significant because it will allow for more informed clinical decision making and better allocation of resources to appropriate treatments, thereby making advances in the field toward more personalized medicine, as opposed to a one-size-fits-all clinical approach. The proposed research is innovative, in the applicants' opinions, because it represents a substantive departure from the status quo by quantifying sources of genetic and cognitive variability that may influence responsiveness to restorative therapy, which the applicants propound can be used both clinically and in research to improve patient outcomes.
项目概要 对决定某人是否愿意的患者特定因素的不完全了解 中风后对语言治疗的反应良好限制了针对或治疗的方法的开发 考虑变异性的来源。遗传学很有可能在其中发挥作用 中风后的语言恢复,但很少有研究致力于调查这一点 关联。这一工作的长期目标是通过以下方式最大限度地提高对失语症治疗的反应: 将患者特定因素纳入与治疗计划相关的决策中。整体 该应用程序的目的是识别患者特定因素的模式,包括两个 显示与治疗结果相关的候选基因和认知技能。这 中心假设是 ApoE 和 BDNF 基因型之间存在关系,并且 刺激泛化的工作记忆。拟议项目的理由是 识别影响治疗反应的因素将有助于更好地估计 预后、改进个体分类以选择适当的治疗方案和直接靶向 认知因素以最大化行为收益。该项目的两个具体目标是 确定 (1) ApoE 和 BDNF 基因型影响个体的程度 失语症对治疗有反应,并且(2)工作记忆能力与刺激获取有关 以及贫血治疗后的刺激泛化。患有慢性中风后失语症的人 将接受认知和语言评估,并提供唾液样本进行遗传分析 在参与针对贫血症的提示图片命名疗法之前进行分析。预期的 结果是将 BDNF 和 ApoE 的认知评分和基因型整合到配方中 个体患者对恢复性治疗有反应的概率。这个贡献是 预计将具有重要意义,因为它将允许做出更明智的临床决策 更好地将资源分配给适当的治疗,从而在该领域取得进展 走向更加个性化的医疗,而不是一刀切的临床方法。这 申请人认为,拟议的研究具有创新性,因为它代表了实质性研究 通过量化遗传和认知变异的来源来摆脱现状 可能会影响对恢复性治疗的反应,申请人提出可以 用于临床和研究以改善患者的治疗结果。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A randomized crossover single-case series comparing blocked versus random treatment for anomia.
一项随机交叉单病例系列,比较了贫血的阻断治疗与随机治疗。
  • DOI:
    10.1080/09602011.2022.2050411
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Diedrichs,VictoriaA;Lundine,JenniferP;Blackett,DeenaSchwen;Durfee,AlexandraZezinka;Pan,XueliangJeff;Harnish,StacyM
  • 通讯作者:
    Harnish,StacyM
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Stacy M Harnish其他文献

Stacy M Harnish的其他文献

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{{ truncateString('Stacy M Harnish', 18)}}的其他基金

Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic an Cognitive Predictors of Restorative Treatment Response
为失语症治疗的个性化医疗奠定基础:恢复性治疗反应的遗传和认知预测因素
  • 批准号:
    10477255
  • 财政年份:
    2019
  • 资助金额:
    $ 45.63万
  • 项目类别:
Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic an Cognitive Predictors of Restorative Treatment Response
为失语症治疗的个性化医疗奠定基础:恢复性治疗反应的遗传和认知预测因素
  • 批准号:
    10001492
  • 财政年份:
    2019
  • 资助金额:
    $ 45.63万
  • 项目类别:
Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic an Cognitive Predictors of Restorative Treatment Response
为失语症治疗的个性化医疗奠定基础:恢复性治疗反应的遗传和认知预测因素
  • 批准号:
    10242811
  • 财政年份:
    2019
  • 资助金额:
    $ 45.63万
  • 项目类别:

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失语症贫血治疗中多层次话语结果的决定因素
  • 批准号:
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A Prospective, Controlled Study of Rehabilitation of Anomia in Aphasia
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  • 批准号:
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    2014
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原发性进行性失语症失语症的康复和预防
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