Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia

原发性进行性失语症失语症的康复和预防

• 批准号: 8511600
• 负责人: RHONDA B FRIEDMAN
• 金额: $ 53.22万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8511600
• 关键词: Anomia; Area; Atrophic; Biological Preservation; Brain imaging; Clinical; Cognitive; Communication; Dementia; Diagnosis; Disease; Family; Family Caregiver; Future; Genetic Transcription; Goals; Home environment; Image; Impaired cognition; Impairment; International; Intervention; Language Disorders; Learning; Life; Maintenance; Measures; Memory; Motor; Names; Nerve Degeneration; Outcome; Overlearning; Patients; Pattern; Prevention; Primary Progressive Aphasia; Process; Prophylactic treatment; Psychological reinforcement; Publishing; Quality of life; Reading; Rehabilitation therapy; Research Personnel; Resistance; Retrieval; Semantic Dementias; Staging; Syndrome; Techniques; Testing; Therapeutic; Time; Training; Variant; Writing; base; cerebral atrophy; cognitive function; design; implicit memory; improved; interest; language processing; novel; programs; relating to nervous system; remediation; time interval; treatment effect; treatment response

DESCRIPTION (provided by applicant): The goal of this study is to remediate word-finding problems in patients with Primary Progressive Aphasia (PPA) and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which we attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. Patients with PPA whose naming of pictures has just begun to show signs of decline will receive practice with picture naming in two conditions: viewing the picture and repeating the name; and viewing the picture with its written name, plus reading and writing the name. Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. A scene-description task containing trained items will be used to assess generalization. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Generalization to other exemplars and to other task situations is also predicted. In addition, we will image the brains of the patients to determine whether patterns of brain atrophy can be used to predict treatment response.

描述（由申请人提供）：本研究的目的是纠正原发性进行性失语症（PPA）患者的找词问题，并延缓找词障碍的进一步发展。目前的方法是新颖的，因为它包含预防成分，我们试图加强保持功能的神经连接，使它们随着疾病的进展更能抵抗退化。虽然这项研究的具体目标是找词问题，但成功的结果对于其他旨在预防或逆转痴呆症认知功能下降的研究来说是个好兆头。图片命名刚刚开始出现衰退迹象的 PPA 患者将在两种情况下接受图片命名练习：观看图片并重复名称；观看写有名字的图片，并读并写出名字。在训练后的三个时间间隔，将在每种条件下训练的图片的命名与研究前测试但从未训练的图片的命名进行比较。包含训练项目的场景描述任务将用于评估泛化能力。据预测，将图片与其书面名称配对，再加上写名称的运动任务，将比简单练习观看图片并重复名称带来更大的能力，以便在以后为图片命名。还预测了对其他范例和其他任务情况的推广。此外，我们将对患者的大脑进行成像，以确定脑萎缩的模式是否可以用于预测治疗反应。