Social Stressors, Epigenetics and Health Status in Underrepresented minorities

代表性不足的少数群体的社会压力源、表观遗传学和健康状况

基本信息

  • 批准号:
    10707995
  • 负责人:
  • 金额:
    $ 54.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-21 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

SUMMARY Type 2 Diabetes (T2D) is one of the fastest-growing chronic diseases globally and causes disability, amplified healthcare costs, and mortality. T2D disproportionately afflicts ethnic minorities in the United States (US). Puerto Ricans (PR) have among the highest T2D rates in the U.S. While unhealthy lifestyle behaviors are known contributors to this disparity, the sociocultural environment of PR may be an equally important and understudied component of the excess T2D. Here, we introduce two cohorts: The Boston Puerto Rican Health Study (BPRHS) and Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends (PROSPECT) as complementary cohorts of adults living in the northeast US (MPR) and Puerto Rico (IPR), providing a unique opportunity to understand T2D-related disparities in an at-risk group with different social and environmental settings. Evidence suggests that social factors affect health via epigenomic modifications. However, the related biological pathways are unknown. The study of epigenomic variation within minority populations exposed to different adverse and protective social factors offers a unique opportunity to characterize how environmental exposures and other social stressors interact with genes to influence T2D risk. Our central hypotheses are that 1) MPR are exposed to more adverse social factors and live in less protective social environments than IPR, and 2) this results in DNA methylation (DNAm) profiles consistent with higher T2D risk. We will test these hypotheses in cross-sectional and longitudinal analyses via the following aims: (1) To determine variations in DNAm and their association with T2D prevalence, incidence, and metabolic biomarkers known to contribute to T2D burden in MPR vs. IPR. To achieve this goal and subsequent aims, we will measure ~850K DNAm in paired BPRHS blood samples (n=600 visit (v)1 and n=600 v3) and 600 samples from PROSPECT (v1). (2) To characterize cross-sectional and longitudinal associations between genome-wide DNAm and specific social stressors (i.e., adverse childhood or life events, discrimination), and protective social factors (i.e., social support, coping, resiliency, community connection), along with behavioral factors (healthy diet, physical activity and adequate sleep); and to describe their relationships with metabolic and physiological pathways relevant to risk and control of T2D. (3) To quantify associations between social and behavioral stressors and biological age acceleration in the BPRHS (V1 and V3; ~6 y follow-up) and PROSPECT (V1) cohorts, using DNAm data from Aim 1. Defining mechanisms by which DNAm modifications and associated pathways relate to T2D risk will support the development of innovative strategies in public health to cope with environmental and social stressors to subsequently prevent T2D and related health disparities in vulnerable populations. This proposal will leverage and expand existing resources and established collaborative expertise.
总结 2型糖尿病(T2 D)是全球增长最快的慢性疾病之一, 医疗费用和死亡率。T2 D不成比例地折磨着美国的少数族裔。 波多黎各人(PR)是美国T2 D发病率最高的人之一,而不健康的生活方式行为 众所周知,这种差异的贡献者,公关的社会文化环境可能是一个同样重要的, 过度T2 D的未充分研究的成分。在这里,我们介绍两个队列:波士顿波多黎各健康 研究(BPRHS)和波多黎各的社会心理、环境和慢性疾病的观察性研究 趋势(前景)作为美国东北部(MPR)和波多黎各成年人的补充队列 (IPR),提供了一个独特的机会,以了解T2 D相关的差异,在一个风险群体与不同的 社会和环境设置。有证据表明,社会因素通过表观基因组影响健康 修改.然而,相关的生物学途径是未知的。表观基因组变异的研究 面临各种不利和保护性社会因素的少数群体提供了独特的机会, 描述环境暴露和其他社会压力如何与基因相互作用,以影响T2 D风险。 我们的中心假设是:1)MPR暴露于更多不利的社会因素,生活在保护性较低的环境中 社会环境比IPR,2)这导致DNA甲基化(DNAm)谱与更高的 T2 D风险。我们将通过横向和纵向分析来检验这些假设,目的如下:(1) 确定DNAm的变化及其与T2 D患病率、发病率和代谢的相关性 已知有助于MPR与IPR中T2 D负荷的生物标志物。为了实现这一目标和后续目标,我们 将在配对的BPRHS血液样本(n=600次访视(v)1和n=600次v3)和600份样本中测量约850 K DNAm 前景(v1)(2)为了描述全基因组之间的横向和纵向关联, DNA m和特定的社会压力源(即,不利的童年或生活事件,歧视)和保护性社会 因素(即,社会支持,应对,弹性,社区联系),沿着行为因素(健康 饮食、体力活动和充足的睡眠);并描述它们与代谢和生理 与T2 D风险和控制相关的途径。(3)为了量化社会和行为之间的联系, BPRHS(V1和V3; ~6年随访)和前景(V1)中的压力源和生物年龄加速 队列,使用来自Aim 1的DNAm数据。定义DNA修饰和相关的 与T2 D风险相关的途径将支持公共卫生创新战略的发展, 环境和社会压力因素,以随后防止T2 D和相关的健康差距, 人口。这项提议将利用和扩大现有资源和已建立的协作专门知识。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jose M. Ordovas其他文献

Diet-gut microbiome interaction and its impact on host blood glucose homeostasis: a series of nutritional n-of-1 trials
  • DOI:
    10.1016/j.ebiom.2024.105483
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Yuanqing Fu;Wanglong Gou;Haili Zhong;Yunyi Tian;Hui Zhao;Xinxiu Liang;Menglei Shuai;Lai-Bao Zhuo;Zengliang Jiang;Jun Tang;Jose M. Ordovas;Yu-ming Chen;Ju-Sheng Zheng
  • 通讯作者:
    Ju-Sheng Zheng
Associations of <em>LPL</em> and <em>APOC3</em> gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the <em>APOE</em> locus
  • DOI:
    10.1016/s0022-2275(20)30148-6
  • 发表时间:
    2002-03-01
  • 期刊:
  • 影响因子:
  • 作者:
    Dolores Corella;Marisa Guillén;Carmen Sáiz;Olga Portolés;Antonio Sabater;José Folch;Jose M. Ordovas
  • 通讯作者:
    Jose M. Ordovas
Anti-fatigue and anti-oxidant effects of curcumin supplementation in exhaustive swimming mice emvia/em Nrf2/Keap1 signal pathway
姜黄素补充剂通过 Nrf2/Keap1 信号通路对力竭游泳小鼠的抗疲劳和抗氧化作用
  • DOI:
    10.1016/j.crfs.2022.07.006
  • 发表时间:
    2022-01-01
  • 期刊:
  • 影响因子:
    7.000
  • 作者:
    Yong Chen;Jiajun Wang;Ziheng Jing;Jose M. Ordovas;Jing Wang;Lirong Shen
  • 通讯作者:
    Lirong Shen
MiRNAs as biomarkers of nutritional therapy to achieve T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
miRNAs 作为营养治疗实现冠心病患者 T2DM 缓解的生物标志物:来自 CORDIOPREV 研究
  • DOI:
    10.1038/s41387-025-00362-1
  • 发表时间:
    2025-02-22
  • 期刊:
  • 影响因子:
    5.200
  • 作者:
    Juan Francisco Alcala-Diaz;Antonio Camargo;Cristina Vals-Delgado;Ana Leon-Acuña;Helena Garcia-Fernandez;Antonio P. Arenas-de Larriva;Magdalena Perez-Cardelo;Marina Mora-Ortiz;Pablo Perez-Martinez;Javier Delgado-Lista;Maria Del Mar Malagon;Jose M. Ordovas;Oriol Alberto Rangel-Zuñiga;Jose Lopez-Miranda
  • 通讯作者:
    Jose Lopez-Miranda
Correction to: Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study
  • DOI:
    10.1186/s12933-021-01269-8
  • 发表时间:
    2021-04-17
  • 期刊:
  • 影响因子:
    10.600
  • 作者:
    Elena M. Yubero-Serrano;Juan F. Alcalá-Diaz;Francisco M. Gutierrez-Mariscal;Antonio P. Arenas-de Larriva;Patricia J. Peña-Orihuela;Ruth Blanco-Rojo;Javier Martinez-Botas;Jose D. Torres-Peña;Pablo Perez-Martinez;Jose M. Ordovas;Javier Delgado-Lista;Diego Gómez-Coronado;Jose Lopez-Miranda
  • 通讯作者:
    Jose Lopez-Miranda

Jose M. Ordovas的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jose M. Ordovas', 18)}}的其他基金

Social Stressors, Epigenetics and Health Status in Underrepresented minorities
代表性不足的少数群体的社会压力源、表观遗传学和健康状况
  • 批准号:
    10523174
  • 财政年份:
    2022
  • 资助金额:
    $ 54.22万
  • 项目类别:
Social Stressors, Epigenetics and Health Status in Underrepresented minorities
代表性不足的少数群体的社会压力源、表观遗传学和健康状况
  • 批准号:
    10842568
  • 财政年份:
    2022
  • 资助金额:
    $ 54.22万
  • 项目类别:
LABORATORY
实验室
  • 批准号:
    8238331
  • 财政年份:
    2011
  • 资助金额:
    $ 54.22万
  • 项目类别:
GWAS FOR CARDIOVASCULAR HEALTH IN ELDERLY PUERTO RICANS
GWAS 促进波多黎各老年人的心血管健康
  • 批准号:
    8238326
  • 财政年份:
    2011
  • 资助金额:
    $ 54.22万
  • 项目类别:
LABORATORY
实验室
  • 批准号:
    7881857
  • 财政年份:
    2010
  • 资助金额:
    $ 54.22万
  • 项目类别:
GWAS FOR CARDIOVASCULAR HEALTH IN ELDERLY PUERTO RICANS
GWAS 促进波多黎各老年人的心血管健康
  • 批准号:
    7881850
  • 财政年份:
    2010
  • 资助金额:
    $ 54.22万
  • 项目类别:
PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
PAT 蛋白质:基因-饮食相互作用肥胖风险与健康
  • 批准号:
    7570113
  • 财政年份:
    2007
  • 资助金额:
    $ 54.22万
  • 项目类别:
PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
PAT 蛋白质:基因-饮食相互作用肥胖风险与健康
  • 批准号:
    7342051
  • 财政年份:
    2007
  • 资助金额:
    $ 54.22万
  • 项目类别:
PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
PAT 蛋白质:基因-饮食相互作用肥胖风险与健康
  • 批准号:
    7206707
  • 财政年份:
    2007
  • 资助金额:
    $ 54.22万
  • 项目类别:
Vitamin K: Genetics of Vascular Calcification
维生素 K:血管钙化的遗传学
  • 批准号:
    6894687
  • 财政年份:
    2004
  • 资助金额:
    $ 54.22万
  • 项目类别:

相似海外基金

Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
  • 批准号:
    24K16488
  • 财政年份:
    2024
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
  • 批准号:
    10100360
  • 财政年份:
    2024
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
  • 批准号:
    24K04974
  • 财政年份:
    2024
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
  • 批准号:
    23K01686
  • 财政年份:
    2023
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
  • 批准号:
    23K01692
  • 财政年份:
    2023
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
  • 批准号:
    23K01695
  • 财政年份:
    2023
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
  • 批准号:
    23K01713
  • 财政年份:
    2023
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
  • 批准号:
    2312319
  • 财政年份:
    2023
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
  • 批准号:
    23K01715
  • 财政年份:
    2023
  • 资助金额:
    $ 54.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
  • 批准号:
    10585388
  • 财政年份:
    2023
  • 资助金额:
    $ 54.22万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了