LABORATORY
实验室
基本信息
- 批准号:8238331
- 负责人:
- 金额:$ 25.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-04-01 至 2015-11-30
- 项目状态:已结题
- 来源:
- 关键词:AgingAlbuminsBehaviorBiochemicalBiologicalBiological MarkersBloodBlood specimenBostonC-reactive proteinCandidate Disease GeneCardiovascular DiseasesCaroteneCenter for Translational Science ActivitiesClinical ResearchCreatinineElderlyEnrollmentEnvironmentEpinephrineEvaluationExcretory functionFiltrationFolateGeneticGlycosylated HemoglobinHealthHealth behaviorHeartHome environmentHomocysteineHomocystineHormonesHydrocortisoneInflammationInflammatoryInterleukin-6InterventionLaboratoriesLifeLipidsMeasurementMeasuresMetabolic MarkerNorepinephrineNutritionalNutritional statusPlasmaProcessPsychosocial StressPuerto RicanRisk FactorsSamplingSerumSerum ProteinsSingle Nucleotide PolymorphismStressTumor Necrosis Factor-alphaUrineVitamin B 12Vitamin B6Vitamin DVitaminsallostatic loadcardiovascular disorder riskcardiovascular risk factorcohortdehydroepiandrosteronediet and exercisefollow-upfunctional declinefunctional disabilitygenetic analysishuman TNF proteinintervention programnutritionprogramsurinary
项目摘要
Biological markers are needed to capture the impact of living environment, and accumulated psychosocial
stress, along v^dth effects of health behaviors, including diet and exercise on functional declines and
disabilities associated with aging. The main objective of this core is to provide laboratory support to all
projects. The specific aims ofthe core are to process, analjrze and interpret blood and urinary measures for
each ofthe projects. The core will receive blood samples from the field staff, prepare them for analysis and
distribute to appropriate labs for analysis or storage. Blood analysis of CBC, lipid profile, glycosylated
hemoglobin, albumin, creatinine, C-reactive protein, and serum DHEA-S are performed. Nutritional
measures include plasma vitamin (carotenes, folate, vitamin B6, vitamin B12, 25-hydroxy vitamin D)
concentrations and metabolic markers (homocysteine). We will also perform genetic analysis for candidate
genes in the Genetics Laboratory. Finally, we will analyze urine samples for urinary Cortisol, epinephrine and
norepinephrine excretion in the Clinical and Translational Research Center (CTTRC). Each ofthe coordinated
proposed projects integrates into the program at least some of these dietary, hematologic and genetic
measurements. These functions will be performed for all five projects.
需要生物标记来捕捉生活环境的影响,以及积累的心理社会
压力,沿着健康行为的影响,包括饮食和锻炼对功能下降的影响,
与衰老有关的残疾。该核心的主要目标是为所有人提供实验室支持。
项目核心的具体目标是处理、分析和解释血液和尿液测量结果,
每个项目。核心小组将从现场工作人员那里接收血样,准备进行分析,
分发到适当的实验室进行分析或储存。全血细胞计数、血脂、糖基化的血液分析
检测血红蛋白、白蛋白、肌酸酐、C-反应蛋白和血清DHEA-S。营养
措施包括血浆维生素(胡萝卜素,叶酸,维生素B6,维生素B12,25-羟基维生素D)
浓度和代谢标志物(同型半胱氨酸)。我们还将对候选人进行基因分析
基因实验室里的基因最后,我们将分析尿样中的皮质醇、肾上腺素和
临床和转化研究中心(CTTRC)的去甲肾上腺素排泄。每个协调的
建议的项目至少将这些饮食、血液和遗传方面的一些问题纳入计划,
测量.将为所有五个项目履行这些职能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jose M. Ordovas其他文献
Diet-gut microbiome interaction and its impact on host blood glucose homeostasis: a series of nutritional n-of-1 trials
- DOI:
10.1016/j.ebiom.2024.105483 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Yuanqing Fu;Wanglong Gou;Haili Zhong;Yunyi Tian;Hui Zhao;Xinxiu Liang;Menglei Shuai;Lai-Bao Zhuo;Zengliang Jiang;Jun Tang;Jose M. Ordovas;Yu-ming Chen;Ju-Sheng Zheng - 通讯作者:
Ju-Sheng Zheng
Associations of <em>LPL</em> and <em>APOC3</em> gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the <em>APOE</em> locus
- DOI:
10.1016/s0022-2275(20)30148-6 - 发表时间:
2002-03-01 - 期刊:
- 影响因子:
- 作者:
Dolores Corella;Marisa Guillén;Carmen Sáiz;Olga Portolés;Antonio Sabater;José Folch;Jose M. Ordovas - 通讯作者:
Jose M. Ordovas
Anti-fatigue and anti-oxidant effects of curcumin supplementation in exhaustive swimming mice emvia/em Nrf2/Keap1 signal pathway
姜黄素补充剂通过 Nrf2/Keap1 信号通路对力竭游泳小鼠的抗疲劳和抗氧化作用
- DOI:
10.1016/j.crfs.2022.07.006 - 发表时间:
2022-01-01 - 期刊:
- 影响因子:7.000
- 作者:
Yong Chen;Jiajun Wang;Ziheng Jing;Jose M. Ordovas;Jing Wang;Lirong Shen - 通讯作者:
Lirong Shen
MiRNAs as biomarkers of nutritional therapy to achieve T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
miRNAs 作为营养治疗实现冠心病患者 T2DM 缓解的生物标志物:来自 CORDIOPREV 研究
- DOI:
10.1038/s41387-025-00362-1 - 发表时间:
2025-02-22 - 期刊:
- 影响因子:5.200
- 作者:
Juan Francisco Alcala-Diaz;Antonio Camargo;Cristina Vals-Delgado;Ana Leon-Acuña;Helena Garcia-Fernandez;Antonio P. Arenas-de Larriva;Magdalena Perez-Cardelo;Marina Mora-Ortiz;Pablo Perez-Martinez;Javier Delgado-Lista;Maria Del Mar Malagon;Jose M. Ordovas;Oriol Alberto Rangel-Zuñiga;Jose Lopez-Miranda - 通讯作者:
Jose Lopez-Miranda
Correction to: Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study
- DOI:
10.1186/s12933-021-01269-8 - 发表时间:
2021-04-17 - 期刊:
- 影响因子:10.600
- 作者:
Elena M. Yubero-Serrano;Juan F. Alcalá-Diaz;Francisco M. Gutierrez-Mariscal;Antonio P. Arenas-de Larriva;Patricia J. Peña-Orihuela;Ruth Blanco-Rojo;Javier Martinez-Botas;Jose D. Torres-Peña;Pablo Perez-Martinez;Jose M. Ordovas;Javier Delgado-Lista;Diego Gómez-Coronado;Jose Lopez-Miranda - 通讯作者:
Jose Lopez-Miranda
Jose M. Ordovas的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jose M. Ordovas', 18)}}的其他基金
Social Stressors, Epigenetics and Health Status in Underrepresented minorities
代表性不足的少数群体的社会压力源、表观遗传学和健康状况
- 批准号:
10707995 - 财政年份:2022
- 资助金额:
$ 25.5万 - 项目类别:
Social Stressors, Epigenetics and Health Status in Underrepresented minorities
代表性不足的少数群体的社会压力源、表观遗传学和健康状况
- 批准号:
10523174 - 财政年份:2022
- 资助金额:
$ 25.5万 - 项目类别:
Social Stressors, Epigenetics and Health Status in Underrepresented minorities
代表性不足的少数群体的社会压力源、表观遗传学和健康状况
- 批准号:
10842568 - 财政年份:2022
- 资助金额:
$ 25.5万 - 项目类别:
GWAS FOR CARDIOVASCULAR HEALTH IN ELDERLY PUERTO RICANS
GWAS 促进波多黎各老年人的心血管健康
- 批准号:
8238326 - 财政年份:2011
- 资助金额:
$ 25.5万 - 项目类别:
GWAS FOR CARDIOVASCULAR HEALTH IN ELDERLY PUERTO RICANS
GWAS 促进波多黎各老年人的心血管健康
- 批准号:
7881850 - 财政年份:2010
- 资助金额:
$ 25.5万 - 项目类别:
PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
PAT 蛋白质:基因-饮食相互作用肥胖风险与健康
- 批准号:
7570113 - 财政年份:2007
- 资助金额:
$ 25.5万 - 项目类别:
PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
PAT 蛋白质:基因-饮食相互作用肥胖风险与健康
- 批准号:
7342051 - 财政年份:2007
- 资助金额:
$ 25.5万 - 项目类别:
PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
PAT 蛋白质:基因-饮食相互作用肥胖风险与健康
- 批准号:
7206707 - 财政年份:2007
- 资助金额:
$ 25.5万 - 项目类别:
相似海外基金
Exploiting and enhancing IgE-binding epitopes of the 2S albumins of peanuts and tree nuts
利用和增强花生和坚果 2S 白蛋白的 IgE 结合表位
- 批准号:
10685312 - 财政年份:2021
- 资助金额:
$ 25.5万 - 项目类别:
Exploiting and enhancing IgE-binding epitopes of the 2S albumins of peanuts and tree nuts
利用和增强花生和坚果 2S 白蛋白的 IgE 结合表位
- 批准号:
10490872 - 财政年份:2021
- 资助金额:
$ 25.5万 - 项目类别:
Exploiting and enhancing IgE-binding epitopes of the 2S albumins of peanuts and tree nuts
利用和增强花生和坚果 2S 白蛋白的 IgE 结合表位
- 批准号:
10345963 - 财政年份:2021
- 资助金额:
$ 25.5万 - 项目类别:
Development of Highly Functionalized Serum Albumins as Boron Delivery Carries to Tumor for Neutron Capture Therapy
开发高功能化血清白蛋白作为硼输送至肿瘤以进行中子捕获治疗
- 批准号:
17H02202 - 财政年份:2017
- 资助金额:
$ 25.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Studies on Asymmetric Nitroaldol Reaction using mutant albumins
突变体白蛋白不对称硝醛醇反应的研究
- 批准号:
16K05706 - 财政年份:2016
- 资助金额:
$ 25.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
SPIN LABELING STUDIES OF NORMAL RECOMBINANT & MUTANT HUMAN SERUM ALBUMINS
正常重组的旋转标记研究
- 批准号:
6118869 - 财政年份:1999
- 资助金额:
$ 25.5万 - 项目类别:
COPPER BINDING OF COMMERCIAL, NORMAL RECOMBINANT, & MUTANT HUMAN SERUM ALBUMINS
商业、正常重组的铜结合,
- 批准号:
6118864 - 财政年份:1999
- 资助金额:
$ 25.5万 - 项目类别:
Structure and Metabolism of the Serum Albumins Characteristic of Bisalbuminemia in Fowl
家禽双清蛋白血症血清白蛋白的结构与代谢特征
- 批准号:
67B6472 - 财政年份:1967
- 资助金额:
$ 25.5万 - 项目类别:
Structure and Metabolism of the Serum Albumins Characteristic of Bisalbuminemia
双清蛋白血症血清白蛋白的结构和代谢特征
- 批准号:
65B3344 - 财政年份:1965
- 资助金额:
$ 25.5万 - 项目类别: