LABORATORY

需要生物标记物来捕捉生活环境和积累的心理社会的影响 应激对健康行为的影响，包括饮食和锻炼对功能衰退和 与衰老相关的残疾。该核心的主要目标是为所有人提供实验室支持 项目。核心的具体目标是处理、分析和解释血液和尿液测量 每一个项目。该核心将接收来自外地工作人员的血液样本，准备进行分析和 分发到适当的实验室进行分析或存储。血细胞分析，糖化后的血脂谱 检测血红蛋白、白蛋白、肌酐、C反应蛋白和血清脱氢表雄酮-S。营养丰富 措施包括血浆维生素(胡萝卜素、叶酸、维生素B6、维生素B12、25-羟基维生素D) 浓度和代谢标志物(同型半胱氨酸)。我们还将对候选人进行基因分析 遗传学实验室中的基因。最后，我们将分析尿样中的皮质醇、肾上腺素和 临床和翻译研究中心(CTTRC)的去甲肾上腺素排泄。每一个协调好的 拟议的项目至少将这些饮食、血液和基因方面的一些内容纳入计划 测量。所有五个项目都将履行这些职能。

Biological markers are needed to capture the impact of living environment, and accumulated psychosocial stress, along v^dth effects of health behaviors, including diet and exercise on functional declines and disabilities associated with aging. The main objective of this core is to provide laboratory support to all projects. The specific aims ofthe core are to process, analjrze and interpret blood and urinary measures for each ofthe projects. The core will receive blood samples from the field staff, prepare them for analysis and distribute to appropriate labs for analysis or storage. Blood analysis of CBC, lipid profile, glycosylated hemoglobin, albumin, creatinine, C-reactive protein, and serum DHEA-S are performed. Nutritional measures include plasma vitamin (carotenes, folate, vitamin B6, vitamin B12, 25-hydroxy vitamin D) concentrations and metabolic markers (homocysteine). We will also perform genetic analysis for candidate genes in the Genetics Laboratory. Finally, we will analyze urine samples for urinary Cortisol, epinephrine and norepinephrine excretion in the Clinical and Translational Research Center (CTTRC). Each ofthe coordinated proposed projects integrates into the program at least some of these dietary, hematologic and genetic measurements. These functions will be performed for all five projects.