LABORATORY

需要生物标记来捕捉生活环境的影响，以及积累的心理社会 压力，沿着健康行为的影响，包括饮食和锻炼对功能下降的影响， 与衰老有关的残疾。该核心的主要目标是为所有人提供实验室支持。 项目核心的具体目标是处理、分析和解释血液和尿液测量结果， 每个项目。核心小组将从现场工作人员那里接收血样，准备进行分析， 分发到适当的实验室进行分析或储存。全血细胞计数、血脂、糖基化的血液分析 检测血红蛋白、白蛋白、肌酸酐、C-反应蛋白和血清DHEA-S。营养 措施包括血浆维生素（胡萝卜素，叶酸，维生素B6，维生素B12，25-羟基维生素D） 浓度和代谢标志物（同型半胱氨酸）。我们还将对候选人进行基因分析 基因实验室里的基因最后，我们将分析尿样中的皮质醇、肾上腺素和 临床和转化研究中心（CTTRC）的去甲肾上腺素排泄。每个协调的 建议的项目至少将这些饮食、血液和遗传方面的一些问题纳入计划， 测量.将为所有五个项目履行这些职能。

Biological markers are needed to capture the impact of living environment, and accumulated psychosocial stress, along v^dth effects of health behaviors, including diet and exercise on functional declines and disabilities associated with aging. The main objective of this core is to provide laboratory support to all projects. The specific aims ofthe core are to process, analjrze and interpret blood and urinary measures for each ofthe projects. The core will receive blood samples from the field staff, prepare them for analysis and distribute to appropriate labs for analysis or storage. Blood analysis of CBC, lipid profile, glycosylated hemoglobin, albumin, creatinine, C-reactive protein, and serum DHEA-S are performed. Nutritional measures include plasma vitamin (carotenes, folate, vitamin B6, vitamin B12, 25-hydroxy vitamin D) concentrations and metabolic markers (homocysteine). We will also perform genetic analysis for candidate genes in the Genetics Laboratory. Finally, we will analyze urine samples for urinary Cortisol, epinephrine and norepinephrine excretion in the Clinical and Translational Research Center (CTTRC). Each ofthe coordinated proposed projects integrates into the program at least some of these dietary, hematologic and genetic measurements. These functions will be performed for all five projects.