Indiana Clinical and Translational Sciences Institute

印第安纳临床与转化科学研究所

• 批准号: 10401490
• 负责人: Sharon M Moe
• 金额: $ 540.25万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-18 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10401490
• 关键词: Abbreviations; Address; Automobile Driving; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Collaborations; Communities; Community Health; Contracts; County; Development; Discipline; Disease; Disease Management; Electronic Health Record; Enrollment; Environment; Face; Fostering; Foundations; Funding Opportunities; Goals; Government; Health; Health system; Healthcare; Healthcare Systems; Hospitals; Human; Indiana; Infant Mortality; Informatics; Infrastructure; Institutes; Institutional Review Boards; Intervention; Journals; Knowledge; Laboratories; Longevity; Methodology; Methods; Midwestern United States; Mission; Obesity; Opiate Addiction; Patients; Peer Review; Persons; Phase; Population; Positioning Attribute; Process; Publications; Research; Research Personnel; Research Training; Resources; Schools; Science; Secure; Services; System; Textiles; Therapeutic; Training; Training Programs; Training and Education; Translational Research; United States National Institutes of Health; Universities; Vision; Work; arm; career development; catalyst; community engagement; community partnership; data dissemination; data warehouse; design; health disparity; improved; innovation; medical schools; meetings; member; mortality disparity; novel strategies; patient engagement; population health; precision medicine; programs; public-private partnership; tool; volunteer

Contact PD/PI: Shekhar, Anantha INDIANA CLINICAL AND TRANSLATIONAL SCIENCES INSTITUTE: OVERALL SUMMARY/ABSTRACT The Indiana Clinical and Translational Sciences Institute (Indiana CTSI) was created in 2008 as a statewide laboratory to accelerate clinical and translational research by the three research universities, Indiana, Purdue and Notre Dame, with partner health care systems, local foundations and corporate partners. The mission of the Indiana CTSI is to serve as the statewide catalyst for translational research and improve human health across Indiana, the nation and beyond. The Indiana CTSI fosters a collaborative research environment, provides resources and services to conduct the highest-quality clinical and translational research, offers education and training programs to build a robust translational workforce, engages our community as a partner at all levels, and functions as an exemplary member of the national CTSA network. The principle of continuous innovation cycle of “4Ds”: Design, Demonstrate, Duplicate, and Disseminate guides the Indiana CTSI. The CTSI plans to accomplish its mission through five Specific Aims: Aim I. Expand education and training to build a broader array of translational workforce through its Career development, Education and Research Training (CERT) and related suite of programs. Aim II. Build on the robust Indiana translational research environment of collaboration and engagement with its outstanding Community Health Partnership (CHeP) program and its public-private partnerships throughout the state and beyond. Aim III. Further, strengthen the CTSI’s integrated approach to support translational research across all phases and many scientific disciplines through its Project Development Teams (PDTs), and include a wide variety of populations across the lifespan. Aim IV. Promote scientific approaches to design and implement the best methods and processes that accelerate the transit of ideas and health interventions across the translational stages to reach patients faster. Aim V. Expand on the exceptional capabilities of the Indiana Translational Informatics Program (iTIP). During the next 5 years, the Indiana CTSI 3.0 will not only expand translational research across the state, but also address some of the major community health issues faced by Indiana and the nation. In this section, we first describe the transformative impact the Indiana CTSI has had on the local environment, and outline how it is poised to make greater impact locally and contribute to NCATS’s mission as an ideal Hub in the national CTSA network. Frequently used abbreviations: All IN – All Indiana Health & Research; CERT – Career development, Education and Research Training; CHeP – Community Health Partnerships; CTR – Clinical & Translational Research; EC – Executive Council; iTIP – Indiana Translational Informatics Program; IUB– Indiana University, Bloomington; IUPUI – Indiana University–Purdue University Indianapolis; IU Health – Indiana University Health hospitals; IUSM – Indiana University School of Medicine; ND – University of Notre Dame; PDT – Project development team; PEC – Patient Engagement Core; PU – Purdue University; RKS – Regulatory Knowledge and Support; SERVE – Subject Engagement and Research Volunteer Enrollment. Project Summary/Abstract Page 704 Contact PD/PI: Shekhar, Anantha

联系PD/PI：Shekhar、Anantha 印第安纳州临床和翻译科学研究所：总体 总结/摘要 印第安纳州临床和转化科学研究所（印第安纳州CTSI）成立于2008年，是一个全州范围的 实验室，以加速临床和转化研究的三个研究型大学，印第安纳州，普渡 和圣母院，与合作伙伴的医疗保健系统，当地基金会和企业合作伙伴。的使命 印第安纳州CTSI将作为全州转化研究和改善人类健康的催化剂 遍布印第安纳州全国甚至更远印第安纳州CTSI促进了合作研究环境， 提供资源和服务，以进行最高质量的临床和转化研究，提供 教育和培训计划，以建立一支强大的翻译队伍，使我们的社区成为合作伙伴 在所有层面上，并作为国家CTSA网络的示范成员。连续性原则 “4D”创新周期：设计、演示、复制和传播指导着印第安纳州CTSI。的 CTSI计划通过五个具体目标完成其使命：目标一。扩大教育和培训， 通过职业发展、教育和研究培训， （CERT）和相关程序套件。Aim II.建立在强大的印第安纳州转化研究环境 与其杰出的社区卫生伙伴关系（CHeP）计划及其 公私合作伙伴关系在整个国家和超越。Aim III.此外，加强CTSI的 综合方法，以支持跨所有阶段和许多科学学科的转化研究， 它的项目开发团队（PDT），包括整个生命周期的各种人群。目标四。 促进科学方法来设计和实施加速实现 在各个转化阶段传递想法和健康干预措施，以更快地接触患者。目标五 扩展印第安纳州翻译信息学计划（iTIP）的卓越功能。在下一个 5年来，印第安纳州CTSI 3.0不仅将扩大全州的转化研究，而且还将解决 印第安纳州和全国面临的一些主要社区健康问题。在本节中，我们首先描述 印第安纳州CTSI对当地环境的变革性影响，并概述它将如何 在当地产生更大的影响，并为NCATS的使命做出贡献，成为国家CTSA网络的理想枢纽。 经常使用的缩写：所有IN -所有印第安纳州健康与研究; CERT -职业发展， 教育和研究培训; CHeP -社区卫生伙伴关系; CTR -临床和转化 研究; EC -执行理事会; iTIP -印第安纳州翻译信息学项目; IUB-印第安纳州 大学，布卢明顿; IUPUI -印第安纳州普渡大学印第安纳波利斯分校; IU健康-印第安纳州 IUSM -印第安纳州大学医学院; ND -圣母大学; PDT -项目开发团队; PEC -患者参与核心; PU -普渡大学; RKS - 监管知识和支持; SERVE -受试者参与和研究志愿者招募。 项目摘要/摘要第704页 联系PD/PI：Shekhar、Anantha

项目成果

Advances in the Development and the Applications of Nonviral, Episomal Vectors for Gene Therapy.

• DOI: 10.1089/hum.2020.310
• 发表时间: 2021-10
• 期刊: Human gene therapy
• 影响因子: 4.2
• 作者: Mulia GE;Picanço-Castro V;Stavrou EF;Athanassiadou A;Figueiredo ML
• 通讯作者: Figueiredo ML

Dasiglucagon, a next-generation ready-to-use glucagon analog, for treatment of severe hypoglycemia in children and adolescents with type 1 diabetes: Results of a phase 3, randomized controlled trial.

• DOI: 10.1111/pedi.13220
• 发表时间: 2021-08
• 期刊: Pediatric diabetes
• 影响因子: 3.4
• 作者: Battelino T;Tehranchi R;Bailey T;Dovc K;Melgaard A;Yager Stone J;Woerner S;von dem Berge T;DiMeglio L;Danne T
• 通讯作者: Danne T

The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury.

• DOI: 10.1016/j.neubiorev.2021.08.029
• 发表时间: 2021-11
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Huibregtse ME;Bazarian JJ;Shultz SR;Kawata K
• 通讯作者: Kawata K

Toxicology Test Results for Public Health Surveillance of the Opioid Epidemic: Retrospective Analysis.

• DOI: 10.2196/50936
• 发表时间: 2023
• 期刊: Online journal of public health informatics

Evidence for impaired chronotropic responses to and recovery from 6-minute walk test in women with post-acute COVID-19 syndrome.

• DOI: 10.1113/ep089965
• 发表时间: 2022-07
• 期刊: Experimental physiology
• 影响因子: 2.7
• 作者: Baranauskas MN;Carter SJ
• 通讯作者: Carter SJ