Indiana Core Center for Clinical Research in Musculoskeletal Health

印第安纳州肌肉骨骼健康临床研究核心中心

• 批准号: 10248402
• 负责人: Sharon M Moe
• 金额: $ 77.67万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248402
• 关键词: Achievement; Affect; Aging; Appointment; Autocrine Communication; Back; Basic Science; Big Data; Bioinformatics; Biometry; Bone Diseases; Characteristics; Chronic Disease; Classification; Clinical; Clinical Research; Clinical Trials Design; Communication; Communities; Complex; Computational algorithm; Databases; Development; Diabetes Mellitus; Diagnosis; Disease; Electronic Health Record; Endocrine; Evaluation Methodology; Foundations; Functional disorder; Funding; Genetic; Genomics; Genotype; Goals; Health; Health Care Costs; Healthcare Systems; Human; Human Subject Research; Image; Imaging Techniques; Impairment; Indiana; Individual; Injury; Institutes; Interdisciplinary Study; Joints; Kidney Diseases; Link; Malignant Neoplasms; Measures; Mechanics; Metabolic; Methodology; Molecular; Morphology; Muscle; Musculoskeletal; Musculoskeletal Diseases; Myopathy; Osteoporosis; Outcome; Pain; Pathogenesis; Patients; Phenotype; Physical Function; Population; Precision Health; Prevalence; Prevention; Proteomics; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Sampling; Services; Specificity; Specimen; Standardization; Symptoms; System; Technology; Technology Transfer; Testing; Training; Translational Research; Twin Multiple Birth; United States National Institutes of Health; Universities; Work; bench to bedside; biobank; blood resource; bone; clinical application; clinical center; clinical decision-making; disability; imaging modality; improved; industry partner; innovation; member; metabolomics; molecular phenotype; multidisciplinary; musculoskeletal imaging; new technology; next generation; novel; nutrition; personalized medicine; precision medicine; ranpirnase; recruit; sarcopenia; targeted biomarker; targeted treatment; tissue resource

Musculoskeletal disorders are common and result in significant disability and health care costs. Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The latter is critical to precision or personalized medicine approaches as many musculoskeletal disorders have common clinical presentations of pain and impaired physical function despite diverse pathophysiology. Furthermore, research to date often focuses on bone or muscle and not how they interact. The overarching theme of the Indiana Core Center for Clinical Research (ICCCR) is to enhance clinical research in musculoskeletal disorders and to understand the muscle-bone connection by better defining, or phenotyping, this broad class of disorders in order to advance clinical research. The ICCCR will leverage campus resources of our CTSA that includes Indiana and Purdue Universities, our statewide healthcare system IU Health, the Regenstrief Institute's statewide electronic health record system, and the Precision Health Initiative to enhance clinical research. The ICCCR will work with Thematic Teams of multi-disciplinary investigators to create innovative ways to think about musculoskeletal disorder phenotypes. The ICCCR will support individuals to connect investigators and Thematic Teams to the methodologic and resource cores thereby facilitating access to and help in conducting research that 1) utilizes our vast network of electronic health records, omics, and bioinformatics group to create computable, genetic and molecular phenotypes, 2) develops standardized physical function and imaging modalities to develop functional and morphologic phenotypes, and 3) expands the Indiana Biobank's musculoskeletal tissue and blood resources. The ICCCR will work with community and industry partners to facilitate recruitment and technology transfer and provide pilot funding to support new research. These new and innovative initiatives under the ICCCR will link our musculoskeletal researchers of Indiana Center for Musculoskeletal Research to state of the art resources to identify novel targets for diagnosis and treatment of musculoskeletal disorders. We will challenge the traditional approach of bench to bedside research to instead focus on patient phenotype to bench and back research. This will improve the definition and diagnosis of the many musculoskeletal disorders to diseases that have common pathogenesis and clinical presentations, facilitating personalized medicine by focusing the right treatment for each patient.

肌肉骨骼疾病很常见，会导致严重残疾和医疗保健费用。 肌肉骨骼疾病诊断和治疗的进步需要强大的临床研究 基础设施和改善各种疾病的分类。后者对精度至关重要， 个性化医疗方法，因为许多肌肉骨骼疾病具有共同的临床表现， 疼痛和受损的身体功能，尽管不同的病理生理学。此外，迄今为止的研究经常 专注于骨骼或肌肉而不是它们如何相互作用。印第安纳州核心中心的首要主题是 临床研究（ICCCR）旨在加强肌肉骨骼疾病的临床研究并了解 通过更好地定义或表型分析这一广泛的疾病类别， 临床研究ICCCR将利用包括印第安纳州和普渡大学在内的CTSA的校园资源 大学，我们的全州医疗保健系统IU Health，Regenstrief Institute的全州电子健康 记录系统和精确健康倡议，以加强临床研究。ICCCR将与 多学科研究人员组成的专题小组，以创新的方式思考肌肉骨骼 疾病表型ICCCR将支持个人将调查人员和专题小组与 方法和资源核心，从而促进访问和帮助进行研究，1）利用 我们庞大的电子健康记录、组学和生物信息学网络， 和分子表型，2）开发标准化的身体功能和成像模式，以开发 功能和形态表型，以及3）扩展了印第安纳州生物库的肌肉骨骼组织， 血液资源。ICCCR将与社区和行业合作伙伴合作，促进招聘， 技术转让和提供试点资金以支持新的研究。这些新的创新举措 在ICCCR下，我们将把印第安纳州肌肉骨骼研究中心的肌肉骨骼研究人员与 最先进的资源，以确定新的目标，诊断和治疗肌肉骨骼疾病。 我们将挑战传统的实验室到床边研究的方法，而不是专注于患者的表型 来进行实验研究这将改善许多肌肉骨骼疾病的定义和诊断。 疾病，具有共同的发病机制和临床表现，促进个性化 通过专注于为每位患者提供正确的治疗，