2023 Physiology, Biology and Pathology of Phosphate GRC

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Project Summary/Abstract The 2023 Gordon Research Conference (GRC) “Physiology, Biology and Pathology of Phosphate” will provide cutting edge science and stimulate inter-disciplinary collaborations to facilitate a better understanding of the complexity of normal and pathologic phosphate regulation. This integration, or full understanding, or the systems biology that control this mineral is needed if we are to understand both normal physiology and regulation in different disease states. Investigators that study intestine, kidney, parathyroid glands and bone, each with both unique and common pathways for sensing, signaling, and responding to changes in phosphate concentrations will come together to share new discoveries. These scientists do not normally interact given the diversity of organs involved, and thus this GRC will provide a forum that facilitates scientific exchange among diverse scientists from around the world, working across the translational spectrum and from all career stages. The number of overall participants will be capped at 200 to ensure an environment conducive to friendly exchange, social interactions that facilitate collaborations, and conversations that propel the field forward. The program will have 25 talks organized into nine morning and evening sessions entitled 1) Overview of Phosphate in Health and Disease, 2) Organs Contributing to Phosphate Homeostasis and Endocrine Regulators, 3) Disorders of Phosphate Homeostasis, 4) Organ Crosstalk in the Regulation of Phosphate Balance, 5) Phosphate Sensing, Uptake, Signaling and Effects in cells, 6) Pathologic Effects of Phosphate on Cells, 7) Biology of Phosphate Containing Complexes 8) Measurements and Models, 9) The Intestinal Environment and Regulation of Phosphate Absorption. In each session, selected posters will be presented orally and there will be a facilitated discussion. Poster sessions will be held each day and purposely place investigators from different fields adjacent to each other to facilitate conversation and exchange of methods and ideas to build collaborations. The meeting will also have a “power hour” to focus on the challenges facing women in science, moderated by Co-Chairs and GRC staff. Additional small group opportunities that engage pre and post docs with senior faculty will be organized to provide career advice, identify potential mentors or sponsors, and facilitate collaborations. In summary, this inaugural GRC focusing on the cellular effects and regulation of phosphate homeostasis will facilitate cross-disciplinary collaborations and encourage trainees that the future of this field is exciting.