IgM-BINDING EPITOPES ON INJURES TISSUE

损伤组织上的 IgM 结合表位

• 批准号: 7428735
• 负责人: FRANCIS D MOORE
• 金额: $ 40.92万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-16 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7428735
• 关键词: Antibody Specificity; Antigens; Binding; Blood flow; Burn injury; Complement; Condition; Dependency; Epitopes; Evolution; Human; Immunoglobulin M; Individual; Inflammatory; Injury; Ischemia; Modeling; Mus; Numbers; Peptide Fragments; Reperfusion Injury; Role; Serum; Severities; Specificity; Testing; Tissues; Variant; injured

We have found that both reperfusion injury and thermal burns are critically dependent on a single natural IgM specificity, Without the IgM, injury is signficantly diminished. We have now identified potential antigens to which the IgM and used short peptide fragments to inhibit the evolution of injury in mice that respond normally to injury otherwise. This proposal seeks to determine whether humans manifest a similar pathbiology that is dependent on a limited number of natural antibody specificities. In addition, the proposal seeks to determine whether there are more severe conditions of injury in which these mechanisms no longer apply, and why.

我们已经发现，再灌注损伤和热烧伤都严重依赖于单一的天然IgM， 特异性，没有IgM，损伤显著减少。我们现在已经确定了潜在的抗原， 其中IgM和使用短肽片段来抑制小鼠的损伤进展， 通常是伤害，否则。这项提案旨在确定人类是否表现出类似的 病理生物学依赖于有限数量的天然抗体特异性。此外，提案 试图确定是否有更严重的伤害条件下，这些机制不再 申请，以及为什么。