Physician Scientist Research Training in Pathogenesis of Viral Diseases

描述(申请人提供)：病毒性疾病仍然是对儿童和成人患者群体的主要威胁。近年来，艾滋病毒和SARS等相对较新的人类病原体的迅速出现和传播，与丙型肝炎等持续和长期感染有关的发病率和死亡率的增加，以及病原体的时断性和往往无法解释的重新出现，突显了需要训练有素的调查人员能够对这些公共卫生需求做出快速反应。这项研究培训赠款的目的是使医生(医学博士和医学博士)成为独立的研究人员，特别是在病毒发病机制领域，主要关注病毒/宿主的相互作用。代表这一计划的关键培训人员的12名教职员工在病毒致病方面都有很好的记录，这在两份出版物以及资金和对培训内科科学家的承诺中都有所反映。每个人都在研究生院及其各自的部门中发挥重要作用，并发展了广泛的协作互动，这将为受训人员提供一个关键的和可获得的专业知识网络。这一领域的机构承诺体现在最近成立的新兴感染中心，该中心将允许继续招聘优秀教员，以反映多发性硬化症。并将为受训者提供一个额外的框架，使他们能够受益于这一领域研究的跨学科性质。该培训方案旨在延长医生在完成临床研究金后的培训期限，特别是成人和儿童传染病方面的培训。候选人将在研究金的第二年进入他们的研究培训轨道，并将成为随后两年通过培训补助金资助的候选人。这两年的主要活动(占他们时间的90%)将是对单个项目的实验室调查进行指导。这一经验将通过参加每周的期刊俱乐部、每周的实验室数据会议以及部门、部门和机构的研究会议来补充。该计划的目标是为候选人提供必要的技能和培训，以有效竞争指导科学家奖，作为他们过渡到独立职业生涯的下一步，成为内科科学家。

DESCRIPTION (provided by applicant): Viral diseases continue to be a major threat to both the pediatric as well as the adult patient population. In recent years, the rapid emergence and spread of relatively new human pathogens such as HIV and SARS, the increasing morbidity and mortality associated with persistent and prolonged infection with agents such as Hepatitis C as well as the episodic and often unexplained reemergence of pathogens underscores the necessity of having well trained investigators that can respond rapidly to these public health demands. The goal of this research training grant is to prepare physicians (MD and MD/PhDs) to pursue careers as independent investigators specifically in the area of viral pathogenesis with a primary focus on virus/host interactions. Each of the twelve faculty members representing the key training personnel for this program has a strong track record in the area of viral pathogenesis as reflected in both publications as well as funding and a commitment to training physician-scientists. Each plays a major role in the graduate school as well as their respective departments and has developed extensive collaborative interactions which will provide the trainee a critical and accessible network of expertise. The institutional commitment in this area is reflected by the recent creation of the Emerging Infections Center that will allow continued recruitment of outstanding faculty to reflect Mt. Sinai and will provide an additional framework for trainees to benefit from the interdisciplinary nature of research in this arena. The training program is designed to extend the training period of physicians following completion of their clinical fellowships, particularly in Adult and Pediatric Infectious Diseases. The candidates will enter into their research training track in their second year of fellowship and will be candidates for funding through the training grant for two subsequent years. The major activity (representing 90% of their time) during these two years will be mentored laboratory investigation on an individual project. This experience will be complemented by participation in a weekly journal club, weekly laboratory data sessions as well as divisional, departmental, and institutional research conferences. The goal of this program is to provide the candidate with the necessary skills and training to effectively compete for mentored scientist awards as the next step in their transition to independent careers as physician scientists.