Training in Radiation Oncology

描述(由申请者提供)：该计划旨在为临床医生和科学家提供实验室和/或临床研究的机会。总体目标是促进全日制学术生涯的发展，目标是整合放射肿瘤学的临床、生物和物理研究，以改善癌症的管理。放射治疗是一项涉及放射生物学、医学物理学和临床肿瘤学的多学科实践。我们放射生物学知识的增加可能会进一步增强放射治疗的科学基础和改进治疗方法。先进物理、计算机和工程技术的应用也可能对放射治疗的成功产生影响。将这些科学和技术领域最佳地整合到临床实践中，需要在构成放射肿瘤学的多个方面接受交叉培训的人员。该计划的一个主要目标是为这种整合做出贡献。参与的教职员工的职业道路是实验室和临床研究相结合的。因此，他们可以作为潜在受训者的榜样。此外，我们的团队在将生物学、物理学和临床放射治疗方面的专业知识结合在一起方面是全面和综合的。调强放射治疗(IMRT)的研究就是这种集成的一个例子，它涉及计算机辅助优化、生物物理建模和放射生物学调查以及临床研究。我们的研究计划有三个特别的重点。第一个是调强放射治疗，它涉及重大的技术进步，需要物理、工程和临床医学的整合。第二，在分子放射生物学方面，是由于我们用分子生物学方法对肿瘤基因和表型的认识迅速增加。第三个是生物和分子成像，它结合了我们对癌症分子基础的理解和先进的成像。TROS的导师已经在这些领域制定了主要的研究计划。该计划的一个重要目标是为临床医生和科学家提供这些放射肿瘤学研究方向的培训资源，并在分子医学时代建立实验室和临床之间必要的接口。

DESCRIPTION (provided by applicant): This program for Training in Radiation Oncology Sciences (TROS) is to provide opportunities of laboratory and/or clinical research to clinicians and scientists. The overall objective is to promote the development of full-time academic careers targeted to integrating clinical, biological and physical investigation in radiation oncology, so as to improve the management of cancer. Radiotherapy is a multidisciplinary practice involving radiobiology, medical physics and clinical oncology. Increase in our radiobiological knowledge may further enhance the scientific basis and improve treatment approaches of radiotherapy. The application of advanced physics, computer and engineering technology may also impact on the success of radiotherapy. Optimum integration of these scientific and technical fields into clinical practice requires personnel that are cross-trained in the multiple facets that constitute radiation oncology. A major goal of this program is to contribute to such integration. The participating faculty has career paths that integrate laboratory and clinical research. Thus, they could serve as role models for the potential trainees. In addition, our team is comprehensive and integrated in terms of meshing together the expertise in biology, physics and clinical radiotherapy. One example for such integration is the research of intensity modulated radiotherapy (IMRT), involve computer aided optimization, biophysical modeling and radiobiological investigation, and clinical study. Our research program has three special emphases. The first is in IMRT that involves significant technological advancement, requiring integration of physics, engineering and clinical medicine. The second, in molecular radiobiology, is motivated by the rapid increase in our knowledge of tumor genotype and phenotype with molecular biology approaches. The third is in biological and molecular imaging, which combines our understanding of the molecular basis of cancer and advanced imaging. The mentors of TROS have developed major research programs in these areas. An important goal of this program is to provide resources for training clinicians and scientists in these directions of radiation oncology research and to build the necessary interface between the laboratory and the clinic in the era of molecular medicine.