Microscopy Imaging Center for Research through Observation (MICRO) Core

显微镜成像观察研究中心 (MICRO) 核心

• 批准号: 10712773
• 负责人: Alexander Culley
• 金额: $ 15.88万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712773
• 关键词: Aging; Area; Bacteria; Biological; Biological Sciences; Biology; Biomedical Research; COVID-19 pandemic; COVID-19 pandemic effects; Centers of Research Excellence; Client; Collaborations; Communities; Computers and Advanced Instrumentation; Core Facility; Data; Data Analyses; Education; Educational workshop; Electron Microscope; Electron Microscopy; Elements; Environment; Equipment; Extracellular Matrix Proteins; Faculty; Fluorescent Probes; Fostering; Funding; Goals; Growth; Guidelines; Hawaii; Health; Height; Histology; Human; Image; Image Analysis; Imaging technology; Infrastructure; Institution; Laboratories; Lasers; Leadership; Location; Measures; Mentorship; Microbe; Microbiology; Microdissection; Microscope; Microscopy; Modernization; Outcome; Phase; Preparation; Protocols documentation; Publications; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resolution; Scanning; Scientist; Services; Specimen; Students; Subcellular structure; System; Taxus; Technical Expertise; Techniques; Technology; Tissues; Training; Training Activity; United States National Institutes of Health; Universities; Viral; Visit; Visualization; biological research; career; cost; fluorescence imaging; imaging facilities; instrument; instrumentation; laser tweezer; light microscopy; materials science; member; microbiome; microbiome research; microorganism; microscopic imaging; new technology; novel; optic tweezer; particle; programs; recruit; tool; training opportunity; transmission process; virology; webinar

PROJECT SUMMARY –Microscopy Imaging Center for Research through Observation (MICRO) Advanced microscopy is a fundamental tool in biology that allows scientists to visualize and characterize microbiomes. The Microscopy Imaging Center for Research through Observation (MICRO) Core of the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH) is providing comprehensive imaging instrumentation and technical expertise at the University of Hawaiʻi at Mānoa (UHM) to support research that characterizes microorganisms and their relationship to each other, to host tissues, and to their environment. During Phase 1, the MICRO Core expanded the Biological Electron Microscope Facility by moving into a new laboratory space, adding instrumentation and services. MICRO has the only transmission and scanning electron microscopes (TEM & SEM) in the state of Hawaiʻi supporting biological and biomedical research. The MICRO Core acquired a state-of-the-art confocal laser scanning microscope, and laser microdissection and optical tweezers. Dr. Alexander Culley, an expert in microbiology and virology, will be the Project Leader during Phase 2. One goal will be to modernize and replace aging equipment, add an image analysis workstation, incorporate histology for light microscopy, and develop training modules. An area of focus will be to introduce users to emerging imaging and data analysis techniques, in particular rapidly evolving fluorescence-imaging technologies to advance studies of microorganisms and their microbiomes. Webinars and workshops led by experts in the new technologies will be tailored to the needs of MICRO users. The MICRO Core will continue to be available to researchers across the UHM campus, other local research and educational institutions, and visiting scientists. The MICRO Core will support and broaden the research programs of former, current and newly proposed COBRE Research Project Leaders (RPLs) and their affiliates by providing essential infrastructure and expertise to advance their research and foster collaborations that will positively impact the careers of RPLs and more established investigators. The MICRO Core will foster the growth of the ICEMHH by (i) bringing the Center visibility through its research and training efforts, (ii) keeping its researchers up-to-date on advancing instrumentation and technologies in microscopy and imaging, and (iii) contributing to research capacity.

项目概要-通过观察研究显微成像中心（MICRO） 先进的显微镜是生物学的基本工具，使科学家能够可视化和表征 微生物群落通过观察研究的显微成像中心（MICRO） 环境微生物组和人类健康综合中心（ICEMHH）提供全面的 夏威夷大学马诺阿分校（UHM）的成像仪器和技术专长， 表征微生物及其相互关系、与宿主组织及其相互关系的研究。 环境在第1阶段，MICRO Core通过以下方式扩展了生物电子显微镜设施： 搬进新的实验室空间，增加仪器和服务。微型有唯一的传输 和扫描电子显微镜（TEM & SEM）在夏威夷州支持生物和生物医学 research. MICRO Core获得了最先进的共聚焦激光扫描显微镜， 显微切割和光学镊子。微生物学和病毒学专家亚历山大卡利博士将担任 第二阶段的项目负责人。一个目标将是现代化和更换老化的设备，增加一个形象 分析工作站，纳入光学显微镜的组织学，并开发培训模块。一个重点领域 将向用户介绍新兴的成像和数据分析技术，特别是快速发展的 荧光成像技术，以推进微生物及其微生物组的研究。网络研讨 由新技术专家领导的研讨会将根据MICRO用户的需求量身定制。的 MICRO核心将继续提供给整个UHM校园的研究人员，其他当地研究和 教育机构和访问科学家。微型核心将支持和扩大研究 前任、现任和新提议的COBRE研究项目负责人（RPL）及其附属机构的计划 通过提供必要的基础设施和专业知识，以推进他们的研究和促进合作， 积极影响RPL和更成熟的调查人员的职业生涯。微核心将促进 通过（i）通过其研究和培训工作提高中心的知名度，（ii）保持 它的研究人员在先进的仪器和技术在显微镜和成像的最新，和（iii） 有助于提高研究能力。