Health Outcomes Predict dEmentia in Stroke (HOPES)

项目摘要/摘要 失语症康复研究中心(C-STAR，P50-DC014664)探索康复 以及中风后语言障碍的预后。我们利用各种神经成像技术 技术和行为评估，以确定与恢复相关的因素。近期 我们小组的证据表明，健康指标是预后的指标， 健康状况较差与痴呆症研究中经常涉及的因素有关(存在 合并症、运动率和小血管病变程度)。这项提议将 允许我们检查可改变的(健康的)和不可改变的(基因， 中风)中风失语的危险因素1)预测轻度认知障碍，2)调查 言语和语言治疗的收获，以及3)与我们的神经典型数据集(大脑老化)一起 队列；ABC)，研究与中风认知减退率相关的因素 失语症VS典型的衰老。我们将使用现有的数据库检查这些问题 中风失语症患者(N=104)，包括患者人口统计数据、中风和 失语症数据，以及我们的神经典型数据库(N=96)，其中包括患者 人口统计、遗传数据、神经测量、健康因素和行为)。我们计划的 分析将为以下方面提供新的见解：可修改和不可修改的风险因素 中风后认知功能下降与认知功能下降之间的相互作用 而言语和语言治疗在中风失语症中也取得了进展。

Project Summary/Abstract The Center for the Study of Aphasia Recovery (C-STAR, P50-DC014664) explores recovery and prognosis from language impairments post-stroke. We utilize various neuroimaging techniques and behavioral assessments to identify factors associated with recovery. Recent evidence from our group has shown that measures of health are indicators of prognosis, with poorer health being associated with factors often implicated in dementia research (presence of comorbidities, rate of exercise, and extent of small vessel disease). This proposal will allow us to examine the relationship between modifiable (health) and unmodifiable (genetics, stroke) risk factors in stroke aphasia to 1) predict mild cognitive impairment, 2) investigate speech and language therapy gains, and 3) along with our neurotypical dataset (Aging Brain Cohort; ABC), investigate factors associated with the rate of cognitive decline in stroke aphasia vs typical aging. We will examine these questions using an existing database of individuals with stroke aphasia (N=104) which includes patient demographics, stroke and aphasia data, alongside our neurotypical database (N=96) which includes patient demographic, genetic data, neural measures, health factors and behavior). Our planned analyses will provide novel insights into the modifiable and unmodifiable risk factors for developing cognitive decline following a stroke, and the interaction between cognitive decline and speech and language therapy gains in stroke aphasia.