Probing the neural computations underlying goal-directed decision-making in humans with single-neuron recordings
通过单神经元记录探索人类目标导向决策背后的神经计算
基本信息
- 批准号:10717875
- 负责人:
- 金额:$ 43.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAnimalsAnteriorAreaBehaviorBehavioralBiologicalBrainBrain regionCouplingDataDecision MakingDorsalEpilepsyFunctional disorderGoalsHumanImpairmentIndividualIntelligenceLearningLightMediatingMental disordersModelingMotorNeuronsOutcomePatientsPlayPoliciesPopulationProcessPsychological reinforcementResolutionRewardsRoleStimulusTask PerformancesTestingTimeUpdateWorkcognitive capacitydesignflexibilityfrontal lobelensneuralneuromechanismneuropsychiatryvirtual
项目摘要
Probing the neural computations underlying goal-directed decision-making in humans with single-neuron
recordings
MPIs: Dr. John P. O’Doherty and Dr. Ueli Rutishauser
PROJECT SUMMARY
Flexible goal-directed decision-making is a core aspect of higher-order adaptive biological intelligence. A number
of psychiatric disorders involve impairments in goal-directed decision-making, yet the current lack of even a basic
understanding of how goal-directed action selection is implemented at the neuronal level in humans hinders our
ability to pinpoint these neuropsychiatric dysfunctions. In particular, it is completely unknown how goals, and the
stimuli and actions that need to be selected from in order to pursue them, are represented at the level of single
neurons, nor how goals get selected from available possible goals.
Here we will characterize the functional contribution of human ventromedial prefrontal (vmPFC), dorsal
anterior cingulate (dACC) and pre-supplementary motor area (pre-SMA) in these processes. We will first test the
longstanding proposal never tested at the neuronal level in humans that the value of stimuli is especially
represented by neurons in vmPFC, while the value of actions are more represented by neurons in dorsal cortical
areas such as the pre-SMA. We will then address how goals themselves are represented. In the real world,
animals including humans need to select a goal before any action is performed. Thus, there is a hierarchical
process of goal selection followed by action selection. We hypothesize that the vmPFC plays a specific role in
goal-valuation and selection, while neurons in dorsomedial areas including pre-SMA and dACC will play more of
a role in valuing and selecting the actions that implement the chosen goal. Most decision-making studies focus
either on action or stimulus selection, but don’t address how goals get selected in the first place. We will use
bespoke behavioral tasks to allow us to distinguish between these different goal and action-related computations
and analyze single neuron data simultaneously collected from these brain areas through the lens of
computational reinforcement-learning models. The significance of this proposal is that we will gain for the first
time, a comprehensive understanding of the functions of the human PFC in goal-directed decision-making at
cellular resolution while shedding light on the neural mechanisms of goal-representation and selection which
hitherto has been virtually unstudied. Consequently, the proposed project is highly significant in terms of the
potential impact that will be made toward understanding the distinct role of different human PFC subregions in
goal-directed decision-making.
探索单神经元人类目标导向决策的神经计算
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JOHN P O'DOHERTY其他文献
JOHN P O'DOHERTY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JOHN P O'DOHERTY', 18)}}的其他基金
Determining the explanatory utility of computational reinforcement-learning theories of goal-directed and habitual control at behavioral and neural levels
确定行为和神经层面目标导向和习惯控制的计算强化学习理论的解释效用
- 批准号:
10205983 - 财政年份:2019
- 资助金额:
$ 43.83万 - 项目类别:
Determining the explanatory utility of computational reinforcement-learning theories of goal-directed and habitual control at behavioral and neural levels
确定行为和神经层面目标导向和习惯控制的计算强化学习理论的解释效用
- 批准号:
10620841 - 财政年份:2019
- 资助金额:
$ 43.83万 - 项目类别:
Determining the explanatory utility of computational reinforcement-learning theories of goal-directed and habitual control at behavioral and neural levels
确定行为和神经层面目标导向和习惯控制的计算强化学习理论的解释效用
- 批准号:
10412091 - 财政年份:2019
- 资助金额:
$ 43.83万 - 项目类别:
Determining the neural substrates of model-based and model-free reinforcement-learning during Pavlovian conditioning (Minority Supplement)
确定巴甫洛夫条件反射期间基于模型和无模型强化学习的神经基础(少数补充)
- 批准号:
9355421 - 财政年份:2016
- 资助金额:
$ 43.83万 - 项目类别:
Determining the neural substrates of model-based and model-free reinforcement-learning during Pavlovian conditioning
确定巴甫洛夫条件反射期间基于模型和无模型强化学习的神经基础
- 批准号:
10117323 - 财政年份:2016
- 资助金额:
$ 43.83万 - 项目类别:
Determining the neural substrates of model-based and model-free reinforcement-learning during Pavlovian conditioning
确定巴甫洛夫条件反射期间基于模型和无模型强化学习的神经基础
- 批准号:
9106549 - 财政年份:2016
- 资助金额:
$ 43.83万 - 项目类别:
Project 1 - The Neurobiology of Social Decision-Making: Social Inference and Context
项目 1 - 社会决策的神经生物学:社会推理和背景
- 批准号:
9278567 - 财政年份:2012
- 资助金额:
$ 43.83万 - 项目类别:
Characterizing habitual and goal-directed behavioral control systems in the human
表征人类习惯性和目标导向的行为控制系统
- 批准号:
8448779 - 财政年份:2011
- 资助金额:
$ 43.83万 - 项目类别:
Characterizing habitual and goal-directed behavioral control systems in the human
表征人类习惯性和目标导向的行为控制系统
- 批准号:
8174617 - 财政年份:2011
- 资助金额:
$ 43.83万 - 项目类别:
Characterizing habitual and goal-directed behavioral control systems in the human
表征人类习惯性和目标导向的行为控制系统
- 批准号:
8653956 - 财政年份:2011
- 资助金额:
$ 43.83万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 43.83万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 43.83万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 43.83万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 43.83万 - 项目类别:
Discovery Early Career Researcher Award
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 43.83万 - 项目类别:
Continuing Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 43.83万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 43.83万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Analysis of thermoregulatory mechanisms by the CNS using model animals of female-dominant infectious hypothermia
使用雌性传染性低体温模型动物分析中枢神经系统的体温调节机制
- 批准号:
23KK0126 - 财政年份:2023
- 资助金额:
$ 43.83万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 43.83万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 43.83万 - 项目类别:
Training Grant