Animal Core

动物模型核心将由病理生物学系管理，但将在两个 CWRU的动物资源中心(ARC)和勒纳研究的生物医学资源中心(BRU) 克利夫兰诊所(CC)。此核心的功能操作在提交此 因此，建议的动物模型和细胞分离核心(动物核心)受益于我们的 BRU和ARC设施的经验丰富的人员和现有的基础设施。纳吉医生的 实验室在使用Lieber-DeCarli随机酒精暴露模型方面拥有丰富的经验 大鼠和小鼠(1-4)。在过去的几年里，纳吉博士的团队与每一位私家侦探合作 探索性项目提供大鼠和小鼠急性和慢性疾病后的血浆、组织和分离细胞样本 长期接触酒精。我们在协调所需程序方面有经验，并已进行了 这些功能在BRU和ARC设施中都有。成员之间的合作的最新摘要 克利夫兰酒精中心使用我们先前存在的岩心的样品列在下面的E部分中。

The Animal Model Core will be managed from the Department of Pathobiology, but will be active at both the Animal Resource Center (ARC) at CWRU and the Biomedical Resource Center (BRU) in the Lerner Research Institute at the Cleveland Clinic (CC). The functional operation of this core predates the submission of this proposal and, therefore, the proposed Animal Models and Cell Isolation Core (Animal Core) benefits from our experienced personnel and the existing infrastructure at both the BRU and ARC facilities. Dr. Nagy's laboratory has extensive experience with the use of the Lieber-DeCarli ad libitum ethanol exposure model in both rats and mice (1-4). In the past several years, Dr. Nagy's group has collaborated with each of the Pis on the Exploratory Projects to provide plasma, tissue and isolated cell samples from rats and mice after acute and chronic ethanol exposures. We have experience in coordinating the procedures required and have carried out these functions in both the BRU and ARC facilities. Recent abstracts from collaborations between members of the Cleveland Alcohol Center using samples from our pre-existing core are listed below in section E.