Recruitment of Faculty for Genetic Aging Research

描述（由申请人提供）：人类遗传研究在理解许多人类遗传性状的潜在遗传结构方面取得了显着进展。现在已经确定了数千种孟德尔性状的潜在遗传病变，并且使用全基因组关联研究（GWAS）描述了数百种与常见多态性的关联。在这些成功中，有许多衰老特征，包括痴呆症、帕金森病、黄斑变性和成功衰老，仅举几例。然而，这些研究才刚刚开始详细描述衰老特征的遗传结构，即使是深入研究的痴呆症，也只描述了少数风险结构。 此P30核心应用程序的目标是支持范德比尔特大学医学院新终身教职员工的招聘和启动活动。这个人的研究重点将是衰老的神经遗传学，并进一步关注人类遗传学。他们将在范德比尔特大学医学院分子生理学和生物物理学系人类基因组学（DHG）部门任职。他们还将被任命为人类遗传学研究中心（CHGR）的研究员，这是他们研究活动的主要地点。他们将有机会获得最高级的核心资源，合作和指导。我们的目标是确定和招募一名优秀的候选人，他将补充DHG和CHGR内的现有专业知识，并在衰老的神经遗传学方面进行突破性的研究。为了实现这一目标，我们特别建议在国际上进行招聘，以确定大量合格的申请人，选择最好的候选人，提供启动资源和协作氛围，并提供示范性的指导，以指导这个人通过他们的第一年作为一名教师。

DESCRIPTION (provided by applicant): Human genetic research has made remarkable progress in understanding the underlying genetic architecture of numerous human genetic traits. The underlying genetic lesions for thousands of Mendelian traits have now been identified and hundreds of associations with common polymorphisms have now been described using genome-wide association studies (GWAS). Among these successes are numerous traits of aging, including dementia, Parkinson disease, macular degeneration, and successful aging, to name just a few. However, these studies have just begun the job of describing in detail the genetic architecture of traits of aging, as even for the intensively studied dementias, only a minority of the risk architecture has been described. The goal of this P30 Core application is to support the recruitment and start-up activities of a new tenure track faculty member in the Vanderbilt University School of Medicine. The focus of this individual's research will be the neurogenetics of aging, with a further focus on human genetics. They will have an appointment within the Division of Human Genomics (DHG), Department of Molecular Physiology and Biophysics in the School of Medicine, Vanderbilt University. They will also be appointed as an Investigator within the Center for Human Genetics Research (CHGR), the primary location for their research activities. They will have access to superlative core resources, collaborations and mentoring. Our goal is to identify and recruit an outstanding candidate who will complement the current expertise within the DHG and the CHGR and perform ground-breaking research in the neurogenetics of aging. To achieve this goal, we specifically propose to recruit internationally to identify a large pool of qualified applicants, select the best possible candidate, provide start-up resources and a collaborative atmosphere, and provide exemplary mentoring to guide this individual through their first years as a faculty member.